DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dbp45A and RRP3

DIOPT Version :9

Sequence 1:	NP_476927.1	Gene:	Dbp45A / 35917	FlyBaseID:	FBgn0010220	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_011932.2	Gene:	RRP3 / 856462	SGDID:	S000001107	Length:	501	Species:	Saccharomyces cerevisiae

Alignment Length:	427	Identity:	167/427 - (39%)
Similarity:	245/427 - (57%)	Gaps:	13/427 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FQILGLRPWLVKQLTKLGLKGATPIQQKCIPAILAGQDCIGAAKTGSGKTFAFALPILERLSEEP 73
            |..|.|.|.|::....|.....||||.|.||..|.|.|.||.|:||||||.|||:|||.||..:.
Yeast    83 FSELNLVPELIQACKNLNYSKPTPIQSKAIPPALEGHDIIGLAQTGSGKTAAFAIPILNRLWHDQ 147

  Fly    74 VSHFALVLTPTHELAYQISEQFLVAGQAMGVRVCVVSGGTDQMVESQKLMQRPHIVVAMPGRLAD 138
            ..::|.:|.||.|||.||.|.|...|..||||...:.||.:.|.:::.||::|||::|.||||.|
Yeast   148 EPYYACILAPTRELAQQIKETFDSLGSLMGVRSTCIVGGMNMMDQARDLMRKPHIIIATPGRLMD 212

  Fly   139 HLTGCDTFSFDNLKYLVVDEADRMLNGDFDESLSIIERCLP-KTRQNLFFSATMK---DFIKESS 199
            ||.....||...||:||:|||||:|:.:|...|..|.:.:| :.|....|||||.   |.::.:|
Yeast   213 HLENTKGFSLRKLKFLVMDEADRLLDMEFGPVLDRILKIIPTQERTTYLFSATMTSKIDKLQRAS 277

  Fly   200 IFPIASDCFEWSQDSDVATVETLDQRYLLCADYDRDMVLIEALRKYREENENANVMIFTNTKKYC 264
            :    ::..:.:..:...||:||.|..::.....::..||..|.::    ....::|||.||...
Yeast   278 L----TNPVKCAVSNKYQTVDTLVQTLMVVPGGLKNTYLIYLLNEF----IGKTMIIFTRTKANA 334

  Fly   265 QLLSMTLKNMEIDNVCLHGFMRQKERVAALSRFKSNQIRTLIATDVAARGLDIPSVELVMNHMLP 329
            :.||.....:|.....|||.:.|.:|:.:|..||:.:...|:||||||||||||||::|:|:.:|
Yeast   335 ERLSGLCNLLEFSATALHGDLNQNQRMGSLDLFKAGKRSILVATDVAARGLDIPSVDIVVNYDIP 399

  Fly   330 RTPKEYIHRVGRTARAGRKGMSISIFRFPRDLELLAAIEEEINTKLTEHPIDQRMVERIFMQVNV 394
            ...|.|||||||||||||.|.|||:.. ..||||:..|||.:..||.:..:|:.::..:...|:.
Yeast   400 VDSKSYIHRVGRTARAGRSGKSISLVS-QYDLELILRIEEVLGKKLPKESVDKNIILTLRDSVDK 463

  Fly   395 TRRESEMQLDNNDFDERAQNYRRKTWIMEGKDPDQME 431
            ...|..|:::..:.::.|:...|:..:|..::.|..|
Yeast   464 ANGEVVMEMNRRNKEKIARGKGRRGRMMTRENMDMGE 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp45A	NP_476927.1	SrmB	8..490	CDD:223587	167/427 (39%)
		DEADc	9..197	CDD:238167	88/191 (46%)
		Helicase_C	239..346	CDD:278689	47/106 (44%)
RRP3	NP_011932.2	SrmB	69..490	CDD:223587	164/415 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoFinder	1	1.000	-	-		FOG0001029
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920