Protein Alignment Dbp45A and HCA4

DIOPT Version :10

• Sequence 1: NP_476927.1
• Gene: Dbp45A / 35917
• FlyBaseID: FBgn0010220
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_012501.1
• Gene: HCA4 / 853419
• SGDID: S000003570
• Length: 770
• Species: Saccharomyces cerevisiae
• Alignment Length: 527
• Identity: 157/527 - (29%)
• Similarity: 255/527 - (48%)
• Gaps: 56/527 - (10%)

  Fly     5 EANPFQILGLRPWLVKQLTKLGLKGATPIQQKCIPAILAGQDCIGAAKTGSGKTFAFALPILERL 69
            :|..|:.|.:....:|.|.:......|.||...||..|.|.|.:.|||||||||.||.:|::|:|
Yeast    39 KAKFFKDLPISDPTLKGLRESSFIKLTEIQADSIPVSLQGHDVLAAAKTGSGKTLAFLVPVIEKL 103

  Fly    70 SEEPVSHF----ALVLTPTHELAYQISEQFLVAGQAMGVRVCVVSGGTDQMVESQKLMQRPHIVV 130
            ..|..:.|    ||:::||.|||.||.|.....|........:|.||.|...|.::: .|.:|::
Yeast   104 YREKWTEFDGLGALIISPTRELAMQIYEVLTKIGSHTSFSAGLVIGGKDVKFELERI-SRINILI 167

  Fly   131 AMPGRLADHLTGCDTFSFDNLKYLVVDEADRMLNGDFDESLSIIERCLPKTRQNLFFSATMKDFI 195
            ..|||:..||......:..||:.||:|||||.|:..|.::|..|...|..:||.|.||||....:
Yeast   168 GTPGRILQHLDQAVGLNTSNLQMLVLDEADRCLDMGFKKTLDAIVSTLSPSRQTLLFSATQSQSV 232

  Fly   196 KESSIFPIAS-------DCFEWSQDSDVATVETLDQRYLLCADYDRDMVLIEALRKYREENENAN 253
            .:.:...:..       |..:.|.:.:.:|.|||.|.|:.....|:    ::.|..:.:.:....
Yeast   233 ADLARLSLTDYKTVGTHDVMDGSVNKEASTPETLQQFYIEVPLADK----LDILFSFIKSHLKCK 293

  Fly   254 VMIFTNTKKYCQLLSMTLKNME--IDNVCLHGFMRQKERVAALSRFKSNQIRTLIATDVAARGLD 316
            :::|.::.|....:..|.:.|:  |..:.|||..:|:.|...|.:|...|...|.||||.|||:|
Yeast   294 MIVFLSSSKQVHFVYETFRKMQPGISLMHLHGRQKQRARTETLDKFNRAQQVCLFATDVVARGID 358

  Fly   317 IPSVELVMNHMLPRTPKEYIHRVGRTARAGRKGMSISIFRFPRDLELLAAIEEEINTKLTEHPID 381
            .|:|:.|:....|.....|||||||.||.|:||.|: |...|::.|   |..:.:|.
Yeast   359 FPAVDWVVQVDCPEDVDTYIHRVGRCARYGKKGKSL-IMLTPQEQE---AFLKRLNA-------- 411

  Fly   382 QRMVERIFMQVNVTRRES-EMQLDNNDFDERAQNY-RRKTWIMEGKDPDQMEALYRKKQKDKLRE 444
             |.:|...:.:..::::| :.||.:..|.:....| .:|.:|      ..:.::|  .||||  :
Yeast   412 -RKIEPGKLNIKQSKKKSIKPQLQSLLFKDPELKYLGQKAFI------SYVRSIY--VQKDK--Q 465

  Fly   445 IRRKRKLQHAEPAAS--EEGKALLQDERFKSVDSARFEKKGKGR-----SRATQ-----EDTPTK 497
            :.:..:|...|.|.|  ..|...::.:..|:::.|: |:|...|     |:|.:     ||...:
Yeast   466 VFKFDELPTEEFAYSLGLPGAPKIKMKGMKTIEQAK-ERKNAPRQLAFLSKANEDGEVIEDKSKQ 529

  Fly   498 PLKRLNK 504
            |..:.:|
Yeast   530 PRTKYDK 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbp45A	NP_476927.1	SrmB	9..381	CDD:440279	126/384 (33%)
HCA4	NP_012501.1	DEADc_DDX10	52..249	CDD:350699	70/197 (36%)
		SF2_C_DEAD	266..397	CDD:350174	45/135 (33%)
		DUF4217	431..488	CDD:464056	16/66 (24%)