Protein Alignment Dbp45A and DDX55

DIOPT Version :10

• Sequence 1: NP_476927.1
• Gene: Dbp45A / 35917
• FlyBaseID: FBgn0010220
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_016875199.1
• Gene: DDX55 / 57696
• HGNCID: 20085
• Length: 618
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 166/612 - (27%)
• Similarity: 266/612 - (43%)
• Gaps: 130/612 - (21%)

  Fly    14 LRPWLVKQLTKLGLKGATPIQQKCIPAILAGQDCIGAAKTGSGKTFAFALPIL-------ERLSE 71
            |.|.::..|.:||....||:|...||..:..:|....|.||||||.||.:|||       |:|.:
Human    16 LHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLKK 80

  Fly    72 EPVSHFALVLTPTHELAYQISE-------QFLVAGQAMGVRVCVVSGGTDQMVESQKLMQR-PHI 128
            ..|.  |:::|||.|||.||.|       .|....|.:.:      ||.:...:.::..|: .:|
Human    81 SQVG--AIIITPTRELAIQIDEVLSHFTKHFPEFSQILWI------GGRNPGEDVERFKQQGGNI 137

  Fly   129 VVAMPGRLAD----HLTGCDTFS-FDNLKYLVVDEADRMLNGDFDESLSIIERCLPKTRQNLFFS 188
            :||.||||.|    ...|.|..| ..:|..||:|||||:|:..|:.|::.|...|||.|:...||
Human   138 IVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRTGLFS 202

  Fly   189 AT----MKDFIKESSIFPIASDCFE--WSQDSDVATVETLDQRYLLCADYDRDMVLIEALRKYRE 247
            ||    :::.::.....|:.....|  .:..|...|...|:..|::|...::...|:..||.:::
Human   203 ATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLVHFLRNHKQ 267

  Fly   248 ENENANVMIFTNTKKYC---------------------QLLSMTLKNMEIDNVCLHGFMRQKERV 291
            |.   :::.|..:...|                     :.|.:.:|.::|  :|:||.|:.| |.
Human   268 EK---HLVFFRYSSGLCGRGIRDSARMCSTCACVEYYGKALEVLVKGVKI--MCIHGKMKYK-RN 326

  Fly   292 AALSRFKSNQIRTLIATDVAARGLDIPSVELVMNHMLPRTPKEYIHRVGRTARAGRKGMSISIFR 356
            .....|:..|...|:.|||.|||:|||.|..|:.:..|.....::||.|||||.|..|.:: :|.
Human   327 KIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSAL-VFL 390

  Fly   357 FPRD---LELLA--------AIEEEINT-----KLTEHPIDQRMVERIFMQVNVT------RRES 399
            .|.:   :..||        .::.:.||     ||....:..|.|....|:..|:      :.|.
Human   391 LPMEESYINFLAINQKCPLQEMKPQRNTADLLPKLKSMALADRAVFEKGMKAFVSYVQAYAKHEC 455

  Fly   400 EM--QLDNNDFDERAQNY----RRKTWIMEGKD-PD-----------QMEALYRKKQKDKLREIR 446
            .:  :|.:.||...|:.:    ..|...:.||. ||           ..:...|:||:.||.|.:
Human   456 NLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVNTDTIPFKDKIREKQRQKLLEQQ 520

  Fly   447 RKRKLQHAEPAASEEGKALLQDERFKSVDSARFEKKGKGRSRATQED-------------TPTKP 498
            |:.|.::       ||:......:..|...|:.|||.|...:..:|:             ..|:.
Human   521 RREKTEN-------EGRRKFIKNKAWSKQKAKKEKKKKMNEKRKREEGSDIEDEDMEELLNDTRL 578

  Fly   499 LKRLNK--------EKPVAQKGRADVK 517
            ||:|.|        ||.:...|:..:|
Human   579 LKKLKKGKITEEEFEKGLLTTGKRTIK 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbp45A	NP_476927.1	SrmB	9..381	CDD:440279	126/429 (29%)
DDX55	XP_016875199.1	SrmB	16..438	CDD:440279	128/436 (29%)
		DEADc_DDX55	20..224	CDD:350718	71/211 (34%)
		DUF4217	423..480	CDD:464056	11/56 (20%)