Protein Alignment Dbp45A and DDX27

DIOPT Version :10

• Sequence 1: NP_476927.1
• Gene: Dbp45A / 35917
• FlyBaseID: FBgn0010220
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001335116.2
• Gene: DDX27 / 55661
• HGNCID: 15837
• Length: 796
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 185/585 - (31%)
• Similarity: 282/585 - (48%)
• Gaps: 102/585 - (17%)

  Fly     2 QRKEANPFQILGLRPWLVKQLTKLGLKGATPIQQKCIPAILAGQDCIGAAKTGSGKTFAFALPIL 66
            |..|...||.:.|...|:|.:|.:|.|..||||:.|||..|.|:|....|.||:|||.|||||:|
Human   182 QYDENLSFQDMNLSRPLLKAITAMGFKQPTPIQKACIPVGLLGKDICACAATGTGKTAAFALPVL 246

  Fly    67 ERL----SEEPVSHFALVLTPTHELAYQISEQFLVAGQAMGVRVCVVSGGTDQMVESQKLMQRPH 127
            |||    .:.||:. .|||.||.||..|:........|...:..|:..||.|...:...|...|.
Human   247 ERLIYKPRQAPVTR-VLVLVPTRELGIQVHSVTRQLAQFCNITTCLAVGGLDVKSQEAALRAAPD 310

  Fly   128 IVVAMPGRLADHLTGCDTFSFDNLKYLVVDEAD-------------------------------R 161
            |::|.||||.|||..|.:|...:::.|::||||                               |
Human   311 ILIATPGRLIDHLHNCPSFHLSSIEVLILDEADSPPVDTAWPHAPTLWLLHLPFPQPGAISCPFR 375

  Fly   162 MLNGDFDESLSIIERCLPKTRQNLFFSATMKDFIKESSIFPIASDCFEW-SQDSDVATVETLDQR 225
            ||:..|:|.:..|.|.....||.:.|||||.|.:|:.:...:.:....: :.::|||..  |.|.
Human   376 MLDEYFEEQMKEIIRMCSHHRQTMLFSATMTDEVKDLASVSLKNPVRIFVNSNTDVAPF--LRQE 438

  Fly   226 YLLC---ADYDRDMVLIEAL-RKYREENENANVMIFTNTKKYCQLLSMTLKNMEIDNVCLHGFMR 286
            ::..   .:.||:.::...| |.:.:     :||:||.|||....:.:.|..|.:....|||.:.
Human   439 FIRIRPNREGDREAIVAALLTRTFTD-----HVMLFTQTKKQAHRMHILLGLMGLQVGELHGNLS 498

  Fly   287 QKERVAALSRFKSNQIRTLIATDVAARGLDIPSVELVMNHMLPRTPKEYIHRVGRTARAGRKGMS 351
            |.:|:.||.|||..||..|:|||||||||||..|:.|:|..:|.|.|.|:|||||||||||.|.|
Human   499 QTQRLEALRRFKDEQIDILVATDVAARGLDIEGVKTVINFTMPNTIKHYVHRVGRTARAGRAGRS 563

  Fly   352 ISIF-RFPRDL--ELLAAIEEEINTKLTEHPID---------QRMVERIFMQVNVTRRESEMQLD 404
            :|:. ...|.:  |::.|.:..:..::.  |.|         ::|.:.::..:.:...|.|||
Human   564 VSLVGEDERKMLKEIVKAAKAPVKARIL--PQDVILKFRDKIEKMEKDVYAVLQLEAEEKEMQ-- 624

  Fly   405 NNDFDERAQNYRRKTWIMEGK-----DPDQ--------------MEALY--------RKKQKDKL 442
                ...||....|..:.:||     :|::              .:||.        :||:|..:
Human   625 ----QSEAQINTAKRLLEKGKEAVVQEPERSWFQTKEERKKEKIAKALQEFDLALRGKKKRKKFM 685

  Fly   443 REIRRKRKLQHAEPAASEEGKALLQDERFKSVDSARFEKKGKGRSRATQEDTPTK-PLKRLNKEK 506
            ::.::|.::...|.:..|..||.:..||.     |:..::.| |:||..|:.|.: |.|:..:.|
Human   686 KDAKKKGEMTAEERSQFEILKAQMFAERL-----AKRNRRAK-RARAMPEEEPVRGPAKKQKQGK 744

  Fly   507  506
            Human   745  744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbp45A	NP_476927.1	SrmB	9..381	CDD:440279	149/414 (36%)
DDX27	NP_001335116.2	SrmB	188..608	CDD:440279	151/429 (35%)