DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dbp45A and DDX49

DIOPT Version :9

Sequence 1:	NP_476927.1	Gene:	Dbp45A / 35917	FlyBaseID:	FBgn0010220	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_061943.2	Gene:	DDX49 / 54555	HGNCID:	18684	Length:	483	Species:	Homo sapiens

Alignment Length:	510	Identity:	233/510 - (45%)
Similarity:	331/510 - (64%)	Gaps:	38/510 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FQILGLRPWLVKQLTKLGLKGATPIQQKCIPAILAGQDCIGAAKTGSGKTFAFALPILERLSEEP 73
            |..|||..|||:|..:||||..||:|..||||||.|:||:|.||||||||.||.||||::|||:|
Human     4 FAELGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDP 68

  Fly    74 VSHFALVLTPTHELAYQISEQFLVAGQAMGVRVCVVSGGTDQMVESQKLMQRPHIVVAMPGRLAD 138
            ...|.||||||.||||||:|||.|.|:.:|::.|::.||.|.:.::.:|.::||:|:|.||||||
Human    69 YGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLAD 133

  Fly   139 HLTGCDTFSFDNLKYLVVDEADRMLN---GDFDESLSIIERCLPKTRQNLFFSATMKDFIKESSI 200
            ||...:|||...:::||:|||||:|.   .||...|..|...:|..||.|.||||:.|.::|  :
Human   134 HLRSSNTFSIKKIRFLVMDEADRLLEQGCTDFTVDLEAILAAVPARRQTLLFSATLTDTLRE--L 196

  Fly   201 FPIASD-CFEWSQDSDVATVETLDQRYLLCADYDRDMVLIEALRKYREENENANVMIFTNTKKYC 264
            ..:|:: .|.|...:.|:|||.|||||||..:..:|..|:..::::::|:|:.:::|||||.|.|
Human   197 QGLATNQPFFWEAQAPVSTVEQLDQRYLLVPEKVKDAYLVHLIQRFQDEHEDWSIIIFTNTCKTC 261

  Fly   265 QLLSMTLKNMEIDNVCLHGFMRQKERVAALSRFKSNQIRTLIATDVAARGLDIPSVELVMNHMLP 329
            |:|.|.|:......|.||..|:||||.|||::|||:..|.|||||||:||||||:|::|:||..|
Human   262 QILCMMLRKFSFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTP 326

  Fly   330 RTPKEYIHRVGRTARAGRKGMSISIFRFPRDLELLAAIEEEINTKLTEHPIDQRMVERIFMQVNV 394
            ..||.|||||||||||||:|.:|::.. ..|:.|:.||||:|..||.|..:::..|.:|..||||
Human   327 GLPKIYIHRVGRTARAGRQGQAITLVT-QYDIHLVHAIEEQIKKKLEEFSVEEAEVLQILTQVNV 390

  Fly   395 TRRESEMQLDNNDFDERAQNYRRKTWIMEGKDPDQMEALYRKKQKDKLREIRRKRKLQHAEPAAS 459
            .|||.|::|:...|||:.:..:||..|:|||||| :||    |:|.:|.:|::|.:
Human   391 VRRECEIKLEAAHFDEKKEINKRKQLILEGKDPD-LEA----KRKAELAKIKQKNR--------- 441

  Fly   460 EEGKALLQDERFKS--VDSARFEKKGKGRSRATQEDTPTKPLKRLNKEKPVAQKG 512
                      |||.  .::.:.:|.|:...:.....||:.     :...||..:|
Human   442 ----------RFKEKVEETLKRQKAGRAGHKGRPPRTPSG-----SHSGPVPSQG 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp45A	NP_476927.1	SrmB	8..490	CDD:223587	228/486 (47%)
		DEADc	9..197	CDD:238167	103/190 (54%)
		Helicase_C	239..346	CDD:278689	58/106 (55%)
DDX49	NP_061943.2	SrmB	1..467	CDD:223587	228/489 (47%)
		Q motif	2..30		14/25 (56%)
		DEAD box	152..155		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..483		8/43 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159708
Domainoid	1	1.000	127	1.000	Domainoid score	I5394
eggNOG	1	0.900	-	-		E2759_KOG0340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41308
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1794
Isobase	1	0.950	-	0	Normalized mean entropy	S721
OMA	1	1.010	-	-		QHG53695
OrthoDB	1	1.010	-	-		D314577at33208
OrthoFinder	1	1.000	-	-		FOG0001029
OrthoInspector	1	1.000	-	-		oto90170
orthoMCL	1	0.900	-	-		OOG6_102828
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2082
SonicParanoid	1	1.000	-	-		X3550
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750