Protein Alignment Dbp45A and DDX49

DIOPT Version :10

• Sequence 1: NP_476927.1
• Gene: Dbp45A / 35917
• FlyBaseID: FBgn0010220
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_061943.2
• Gene: DDX49 / 54555
• HGNCID: 18684
• Length: 483
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 233/510 - (45%)
• Similarity: 331/510 - (64%)
• Gaps: 38/510 - (7%)

  Fly     9 FQILGLRPWLVKQLTKLGLKGATPIQQKCIPAILAGQDCIGAAKTGSGKTFAFALPILERLSEEP 73
            |..|||..|||:|..:||||..||:|..||||||.|:||:|.||||||||.||.||||::|||:|
Human     4 FAELGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDP 68

  Fly    74 VSHFALVLTPTHELAYQISEQFLVAGQAMGVRVCVVSGGTDQMVESQKLMQRPHIVVAMPGRLAD 138
            ...|.||||||.||||||:|||.|.|:.:|::.|::.||.|.:.::.:|.::||:|:|.||||||
Human    69 YGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLAD 133

  Fly   139 HLTGCDTFSFDNLKYLVVDEADRMLN---GDFDESLSIIERCLPKTRQNLFFSATMKDFIKESSI 200
            ||...:|||...:::||:|||||:|.   .||...|..|...:|..||.|.||||:.|.::|  :
Human   134 HLRSSNTFSIKKIRFLVMDEADRLLEQGCTDFTVDLEAILAAVPARRQTLLFSATLTDTLRE--L 196

  Fly   201 FPIASD-CFEWSQDSDVATVETLDQRYLLCADYDRDMVLIEALRKYREENENANVMIFTNTKKYC 264
            ..:|:: .|.|...:.|:|||.|||||||..:..:|..|:..::::::|:|:.:::|||||.|.|
Human   197 QGLATNQPFFWEAQAPVSTVEQLDQRYLLVPEKVKDAYLVHLIQRFQDEHEDWSIIIFTNTCKTC 261

  Fly   265 QLLSMTLKNMEIDNVCLHGFMRQKERVAALSRFKSNQIRTLIATDVAARGLDIPSVELVMNHMLP 329
            |:|.|.|:......|.||..|:||||.|||::|||:..|.|||||||:||||||:|::|:||..|
Human   262 QILCMMLRKFSFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTP 326

  Fly   330 RTPKEYIHRVGRTARAGRKGMSISIFRFPRDLELLAAIEEEINTKLTEHPIDQRMVERIFMQVNV 394
            ..||.|||||||||||||:|.:|::.. ..|:.|:.||||:|..||.|..:::..|.:|..||||
Human   327 GLPKIYIHRVGRTARAGRQGQAITLVT-QYDIHLVHAIEEQIKKKLEEFSVEEAEVLQILTQVNV 390

  Fly   395 TRRESEMQLDNNDFDERAQNYRRKTWIMEGKDPDQMEALYRKKQKDKLREIRRKRKLQHAEPAAS 459
            .|||.|::|:...|||:.:..:||..|:|||||| :||    |:|.:|.:|::|.:
Human   391 VRRECEIKLEAAHFDEKKEINKRKQLILEGKDPD-LEA----KRKAELAKIKQKNR--------- 441

  Fly   460 EEGKALLQDERFKS--VDSARFEKKGKGRSRATQEDTPTKPLKRLNKEKPVAQKG 512
                      |||.  .::.:.:|.|:...:.....||:.     :...||..:|
Human   442 ----------RFKEKVEETLKRQKAGRAGHKGRPPRTPSG-----SHSGPVPSQG 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbp45A	NP_476927.1	SrmB	9..381	CDD:440279	193/375 (51%)
DDX49	NP_061943.2	SrmB	1..441	CDD:440279	223/444 (50%)
		Q motif	2..30		14/25 (56%)
		DEAD box	152..155		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..483		8/43 (19%)