DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dbp45A and ddx49

DIOPT Version :9

Sequence 1:	NP_476927.1	Gene:	Dbp45A / 35917	FlyBaseID:	FBgn0010220	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_938179.1	Gene:	ddx49 / 386632	ZFINID:	ZDB-GENE-031030-3	Length:	468	Species:	Danio rerio

Alignment Length:	459	Identity:	218/459 - (47%)
Similarity:	320/459 - (69%)	Gaps:	11/459 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FQILGLRPWLVKQLTKLGLKGATPIQQKCIPAILAGQDCIGAAKTGSGKTFAFALPILERLSEEP 73
            |:.|||..||::|..::|:...|.:|:|||||||.|:||:|.||||||||.||.||:|::|||:|
Zfish     4 FESLGLSEWLIQQCKQMGISRPTAVQEKCIPAILDGRDCMGCAKTGSGKTAAFVLPVLQKLSEDP 68

  Fly    74 VSHFALVLTPTHELAYQISEQFLVAGQAMGVRVCVVSGGTDQMVESQKLMQRPHIVVAMPGRLAD 138
            ...|.||||||.||||||:|||.|.|:.:|::.|::.||.|.:.:..:|.::||:|||.||||||
Zfish    69 YGVFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVTQGLELSKKPHVVVATPGRLAD 133

  Fly   139 HLTGCDTFSFDNLKYLVVDEADRMLN---GDFDESLSIIERCLPKTRQNLFFSATMKDFIKESSI 200
            |:...||.:.:.:::|::|||||:|.   .||.:.|.:|...:|..||.|.||||:.|.:::...
Zfish   134 HIRSSDTINLNRIQFLIMDEADRLLEQGCTDFTKDLEVILSAVPAKRQTLLFSATLTDTLQQLQS 198

  Fly   201 FPIASDCFEWSQDSDVATVETLDQRYLLCADYDRDMVLIEALRKYREENENANVMIFTNTKKYCQ 265
            ..:....| |...|||.|||.||||::|..:..:|..|:..::.:::|:::.:::|||||.|.||
Zfish   199 IAMNRPFF-WEHKSDVQTVEELDQRFILTPEKVKDAYLVHLIQTFQDEHDDWSIIIFTNTCKSCQ 262

  Fly   266 LLSMTLKNMEIDNVCLHGFMRQKERVAALSRFKSNQIRTLIATDVAARGLDIPSVELVMNHMLPR 330
            :|:|.|:......:.||..|:|::|.|.|::||||..:.||||||||||||||:|::|:||..|.
Zfish   263 ILTMMLREFNFPTISLHSMMKQRQRFANLAKFKSNVFKILIATDVAARGLDIPTVQVVINHNTPG 327

  Fly   331 TPKEYIHRVGRTARAGRKGMSISIFRFPRDLELLAAIEEEINTKLTEHPIDQRMVERIFMQVNVT 395
            .||.|||||||||||||.|:||::.. ..|:.|:.||||:..|||.|.||:::.|.:|..|||||
Zfish   328 LPKIYIHRVGRTARAGRNGVSITLVT-QYDIHLINAIEEQNQTKLKEFPIEEKEVLKILTQVNVT 391

  Fly   396 RRESEMQLDNNDFDERAQNYRRKTWIMEGKDPDQMEALYRKKQKDKLREIRRK-RKLQHAEPAAS 459
            ||:.|::|::.||||:.:..:||..|::|||||..|     |:|::|.:||.| :||:...|.:.
Zfish   392 RRQCEIKLESTDFDEKKKINKRKQMILDGKDPDLEE-----KRKNELEKIRGKNKKLKGKNPQSK 451

  Fly   460 EEGK 463
            :|.|
Zfish   452 KEKK 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp45A	NP_476927.1	SrmB	8..490	CDD:223587	218/459 (47%)
		DEADc	9..197	CDD:238167	96/190 (51%)
		Helicase_C	239..346	CDD:278689	54/106 (51%)
ddx49	NP_938179.1	PRK11192	3..415	CDD:236877	199/412 (48%)
		DEADc	4..206	CDD:238167	96/201 (48%)
		HELICc	218..351	CDD:238034	67/132 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595926
Domainoid	1	1.000	123	1.000	Domainoid score	I5562
eggNOG	1	0.900	-	-		E2759_KOG0340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41308
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1707
OMA	1	1.010	-	-		QHG53695
OrthoDB	1	1.010	-	-		D314577at33208
OrthoFinder	1	1.000	-	-		FOG0001029
OrthoInspector	1	1.000	-	-		oto41474
orthoMCL	1	0.900	-	-		OOG6_102828
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2082
SonicParanoid	1	1.000	-	-		X3550
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800