Protein Alignment Dbp45A and Ddx49

DIOPT Version :9

• Sequence 1: NP_476927.1
• Gene: Dbp45A / 35917
• FlyBaseID: FBgn0010220
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001108495.1
• Gene: Ddx49 / 290660
• RGDID: 1311124
• Length: 480
• Species: Rattus norvegicus
• Alignment Length: 499
• Identity: 232/499 - (46%)
• Similarity: 322/499 - (64%)
• Gaps: 34/499 - (6%)

  Fly     9 FQILGLRPWLVKQLTKLGLKGATPIQQKCIPAILAGQDCIGAAKTGSGKTFAFALPILERLSEEP 73
            |..|.|..|||:|..:||||..||:|..||||||.|:||:|.||||||||.||.||||::|||:|
  Rat     4 FAELRLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDP 68

  Fly    74 VSHFALVLTPTHELAYQISEQFLVAGQAMGVRVCVVSGGTDQMVESQKLMQRPHIVVAMPGRLAD 138
            ...|.||||||.||||||:|||.|.|:.:|::.|::.||.|.:.::.:|.::||:|:|.||||||
  Rat    69 YGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVTQALELSRKPHVVIATPGRLAD 133

  Fly   139 HLTGCDTFSFDNLKYLVVDEADRMLN---GDFDESLSIIERCLPKTRQNLFFSATMKDFIKESSI 200
            ||...:||:...:::||:|||||:|.   .||...|..|...:|..||.|.||||:.|.:||  :
  Rat   134 HLRSSNTFNMKKIRFLVLDEADRLLEQGCTDFTADLETILSAVPARRQTLLFSATLTDTLKE--L 196

  Fly   201 FPIASD-CFEWSQDSDVATVETLDQRYLLCADYDRDMVLIEALRKYREENENANVMIFTNTKKYC 264
            ..:|:: .|.|...:.|..||.|||||||..:..:|..|:..::.::::.|:.:::|||||.|.|
  Rat   197 QGLATNQPFFWEAQATVRMVEQLDQRYLLVPEKVKDAYLVHLVQTFQDQLEDCSIIIFTNTCKTC 261

  Fly   265 QLLSMTLKNMEIDNVCLHGFMRQKERVAALSRFKSNQIRTLIATDVAARGLDIPSVELVMNHMLP 329
            |:|.|.|:......|.||..|:||||.|||:||||:..|.|||||||:||||||:|::|:||..|
  Rat   262 QILCMMLRKFNFPTVALHSMMKQKERFAALARFKSSTYRILIATDVASRGLDIPTVQVVINHNTP 326

  Fly   330 RTPKEYIHRVGRTARAGRKGMSISIFRFPRDLELLAAIEEEINTKLTEHPIDQRMVERIFMQVNV 394
            ..||.|||||||||||||:|.:|::.. ..|:.||.||||||..:|.|..:::..|.:|..||||
  Rat   327 GLPKIYIHRVGRTARAGRQGQAITLVT-QYDIHLLHAIEEEIKQQLAELAVEEAQVLQILTQVNV 390

  Fly   395 TRRESEMQLDNNDFDERAQNYRRKTWIMEGKDPDQMEALYRKKQKDKLREIRRKRKLQHAEPAAS 459
            .|||.|::|:.:.|||:.:..:||..|:|||||| :||    |:|.:|.:|::
  Rat   391 VRRECEIKLEASHFDEKKEINKRKQMILEGKDPD-LEA----KRKAELAKIKQ------------ 438

  Fly   460 EEGKALLQDERFKS--VDSARFEKKGK-GRSRATQEDTPTKPLK 500
                   |:.|||.  ..:.|.:|.|. ||........|.:|.:
  Rat   439 -------QNRRFKEKVEQTLRQQKAGSTGRRSRPPRPRPQEPAR 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbp45A	NP_476927.1	SrmB	8..490	CDD:223587	230/487 (47%)
		DEADc	9..197	CDD:238167	101/190 (53%)
		Helicase_C	239..346	CDD:278689	58/106 (55%)
Ddx49	NP_001108495.1	PTZ00424	4..382	CDD:185609	192/380 (51%)
		DEADc	4..206	CDD:238167	104/203 (51%)
		HELICc	218..351	CDD:238034	72/132 (55%)
		DUF2317	<363..454	CDD:302887	41/114 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353777
Domainoid	1	1.000	125	1.000	Domainoid score	I5343
eggNOG	1	0.900	-	-		E2759_KOG0340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41308
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1749
OMA	1	1.010	-	-		QHG53695
OrthoDB	1	1.010	-	-		D314577at33208
OrthoFinder	1	1.000	-	-		FOG0001029
OrthoInspector	1	1.000	-	-		oto97288
orthoMCL	1	0.900	-	-		OOG6_102828
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3550
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770