DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNT1 and Slc28a2

DIOPT Version :9

Sequence 1:	NP_610447.2	Gene:	CNT1 / 35915	FlyBaseID:	FBgn0033371	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_113852.2	Gene:	Slc28a2 / 60423	RGDID:	61840	Length:	659	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	202/497 - (40%)
Similarity:	309/497 - (62%)	Gaps:	22/497 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 CQINWCHGYGFLIVLFILFYILWLYYWVFKPFVGIKLYNNYLEPVIDKWIAFSRQWIVSGVMLAI 163
            |.:|:.......::..::.:||..::  .|.|...|.. ..|:|:.:..:   |.|:....|.|.
  Rat    98 CILNFRRAQALFVITCLVIFILACHF--LKKFFAKKSI-RCLKPLKNTRL---RLWLKRVFMGAA 156

  Fly   164 VLAVVVAYLGFECRNDAYKAIGLLGPVCFVLIGFAVSKHHLQVPWRIVTHGLLGQLLLGILCLRL 228
            |:.::: :|..:......:.|...|...|:||.||.||||..|.||.|..||..|.:.|||.:|.
  Rat   157 VVGLIL-WLALDTAQRPEQLISFAGICMFILILFACSKHHSAVSWRTVFWGLGLQFVFGILVIRT 220

  Fly   229 PFGRSIFQCLGDKVTIFLNYAQHGARFVYGDRICDEYVFAFAILAVVFFFSVITSIMYYLGWMQF 293
            ..|.:.||.|||::.|||.|...|:.||:||.:. :.||||..|.::.||..:.||:||||.:|:
  Rat   221 EPGFNAFQWLGDQIQIFLAYTVEGSSFVFGDTLV-QSVFAFQSLPIIIFFGCVMSILYYLGLVQW 284

  Fly   294 ILNGFGFLLQAMVGTTVCESVNAAGNVFLSMTESPLVIRPYIEILTVSELHAICTSGYATVAGTV 358
            ::....:.||..:|||..|::..|||:|:.|||:||:||||:..:|:||:||:.|.|:||:||||
  Rat   285 VIQKIAWFLQITMGTTAAETLAVAGNIFVGMTEAPLLIRPYLADMTLSEIHAVMTGGFATIAGTV 349

  Fly   359 LGAYVSFGASASFLIAASVMAAPGSLAFAKLFYPETEESLTRS-DNIKLESSTDTSILDAAASGA 422
            |||::|||..||.||:|||||||.:||.:||.|||.|||..:| :.:||....:.:||:||::||
  Rat   350 LGAFISFGIDASSLISASVMAAPCALALSKLVYPEVEESKFKSKEGVKLPRGEERNILEAASNGA 414

  Fly   423 AAALLIVLGIVSNIIAFLAIVFFLDAVTEWIFELIGLHNITLLYILSQIFIPIVFVMGVPWHDCQ 487
            ..|:.:|..:.:|:|||||::.|:::...|:.|::.:|.:|...|.|.:..|:||:|||.|.||.
  Rat   415 TDAIGLVANVAANLIAFLAVLAFINSTLSWLGEMVDIHGLTFQVICSYVLRPMVFMMGVQWADCP 479

  Fly   488 AIGLVVAQKSFINEFVAYRNL---------GI---LVSDKK-VDPRSAAIATFALCGFANPGSLG 539
            .:..:|..|.||||||||:.|         |:   :..:|: :..::..||||:||||||..|:|
  Rat   480 LVAEIVGVKFFINEFVAYQQLSQYKNKRLSGVEEWINGEKQWISVKAEIIATFSLCGFANLTSIG 544

  Fly   540 IVIASLSAMAPSRRSDITRVAFRSYFAGSFVSFTSASLAGIL 581
            |.:..|::|.|.|:||:.::..|:.|.|:.|||.||.:||||
  Rat   545 ITLGGLTSMVPQRKSDLCKLVVRALFTGACVSFISACMAGIL 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNT1	NP_610447.2	nupC	184..581	CDD:273278	185/410 (45%)
		Nucleos_tra2_N	188..257	CDD:280026	33/68 (49%)
		Gate	271..366	CDD:284976	46/94 (49%)
		Nucleos_tra2_C	372..581	CDD:284970	94/222 (42%)
Slc28a2	NP_113852.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
Slc28a2	NP_113852.2	nupC	175..586	CDD:273278	185/411 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350952
Domainoid	1	1.000	191	1.000	Domainoid score	I3137
eggNOG	1	0.900	-	-		E1_COG1972
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20891
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2019
OMA	1	1.010	-	-		QHG63093
OrthoDB	1	1.010	-	-		D251221at33208
OrthoFinder	1	1.000	-	-		FOG0001233
OrthoInspector	1	1.000	-	-		mtm9124
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10590
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X691
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870