DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNT1 and Slc28a2b

DIOPT Version :9

Sequence 1:	NP_610447.2	Gene:	CNT1 / 35915	FlyBaseID:	FBgn0033371	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001078987.1	Gene:	Slc28a2b / 381417	MGIID:	3702173	Length:	660	Species:	Mus musculus

Alignment Length:	504	Identity:	195/504 - (38%)
Similarity:	301/504 - (59%)	Gaps:	36/504 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 CQINWCHGYGFLIVLFILFYILWLYYWVFKPFVGIKL------YNNYLEPVIDKWIAFSRQWIVS 157
            |.:|:.......::..::|:|. .|:::.| |...||      :.|:.       :....:|::.
Mouse    99 CILNFQRALALFVITCLVFFIS-AYHFLEK-FPAKKLIRCLSCFRNFC-------LRRCLKWVLP 154

  Fly   158 GVMLAIVLAVVVAYLGFECRNDAYKAIGLLGPVCFVLIGFAVSKHHLQVPWRIVTHGLLGQLLLG 222
            |   |.|::.:: :|..:......:.|...|...|:||.||.||||..|.||.|..||..|.:.|
Mouse   155 G---ASVVSQIL-WLVLDTAQRPEQLISFAGICMFILILFACSKHHSAVCWRTVFWGLGLQFIFG 215

  Fly   223 ILCLRLPFGRSIFQCLGDKVTIFLNYAQHGARFVYGDRICDEYVFAFAILAVVFFFSVITSIMYY 287
            ||.:|...|.:.||.|||::.|||.|...|:.||:||.:... ||||..|.::.||..:.||:||
Mouse   216 ILVIRTEPGFNAFQWLGDQIQIFLAYTVEGSSFVFGDTLVYN-VFAFQSLPIIIFFGCVMSILYY 279

  Fly   288 LGWMQFILNGFGFLLQAMVGTTVCESVNAAGNVFLSMTESPLVIRPYIEILTVSELHAICTSGYA 352
            ||.:|:::......||:.:|||..|::..|||:|:.:||.||:||||:..:|:||:||:.|.|:|
Mouse   280 LGLVQWVIQKIALFLQSKMGTTAPETLAMAGNIFVGLTEVPLLIRPYLADMTISEIHAVMTGGFA 344

  Fly   353 TVAGTVLGAYVSFGASASFLIAASVMAAPGSLAFAKLFYPETEESLTRS-DNIKLESSTDTSILD 416
            |:|||:|||::|||..||.||:|||||||.:||.:||.|||.:||..:| :.:||....:.:||:
Mouse   345 TIAGTMLGAFISFGIDASSLISASVMAAPCALALSKLVYPEVKESKFKSKEGLKLPRGEERNILE 409

  Fly   417 AAASGAAAALLIVLGIVSNIIAFLAIVFFLDAVTEWIFELIGLHNITLLYILSQIFIPIVFVMGV 481
            ||::||..|:.:|..:.:|:|||||::.|::|...|:.|::....::...|.|.|..|:.|:|.|
Mouse   410 AASNGATEAISLVANVAANLIAFLAVLAFVNATLSWLGEMVDFRGLSFQVICSYILRPMAFMMAV 474

  Fly   482 PWHDCQAIGLVVAQKSFINEFVAYRNLGILVSDKK--------------VDPRSAAIATFALCGF 532
            .|.||..:..:|..|.||||||||:.| |...:|:              :..::..|.||:||||
Mouse   475 QWTDCLLVIEIVGVKFFINEFVAYQQL-IQYKNKRLSGVEEWINGEKQWISVKAEIITTFSLCGF 538

  Fly   533 ANPGSLGIVIASLSAMAPSRRSDITRVAFRSYFAGSFVSFTSASLAGIL 581
            ||..|:||.:..|::|...|:||:.::..|:.|.|:.|||.||.:||||
Mouse   539 ANLSSIGITLGGLTSMITQRKSDLCKIVVRALFTGACVSFISACMAGIL 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNT1	NP_610447.2	nupC	184..581	CDD:273278	178/411 (43%)
		Nucleos_tra2_N	188..257	CDD:280026	33/68 (49%)
		Gate	271..366	CDD:284976	44/94 (47%)
		Nucleos_tra2_C	372..581	CDD:284970	89/223 (40%)
Slc28a2b	NP_001078987.1	nupC	176..587	CDD:273278	178/412 (43%)
		Nucleos_tra2_N	181..250	CDD:280026	33/68 (49%)
		Gate	264..358	CDD:284976	44/93 (47%)
		Nucleos_tra2_C	364..587	CDD:284970	89/223 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847405
Domainoid	1	1.000	190	1.000	Domainoid score	I3256
eggNOG	1	0.900	-	-		E1_COG1972
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2058
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63093
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001233
OrthoInspector	1	1.000	-	-		mtm8877
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X691
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860