DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNT1 and Slc28a3

DIOPT Version :9

Sequence 1:	NP_610447.2	Gene:	CNT1 / 35915	FlyBaseID:	FBgn0033371	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_543184.2	Gene:	Slc28a3 / 140944	RGDID:	621224	Length:	705	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	200/512 - (39%)
Similarity:	307/512 - (59%)	Gaps:	49/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 CQINWCHGYG-FLIVLFILFYILWLYYWVFKPFVGIKLYNNYLEPVID-----------KWIAFS 151
            |.:|:..... |:|.|..:|:::|           .:|...|.:.:.|           .|  |.
  Rat   138 CALNFHRALPLFVITLVTIFFVVW-----------DRLMAKYEQRIDDVLSPGKRLLERHW--FW 189

  Fly   152 RQWIV-SGVMLAIV--LAVVVAYLGFECRNDAYKAIGLLGPVCFVLIGFAVSKHHLQVPWRIVTH 213
            .:|:| ..::||::  ||:..|.||.:      :.|...|.|.::::.|..|||..:|.||.|..
  Rat   190 LKWVVWCSLILAVILWLALDTARLGQQ------QLISFGGLVMYIVLLFLFSKHPTRVYWRPVFW 248

  Fly   214 GLLGQLLLGILCLRLPFGRSIFQCLGDKVTIFLNYAQHGARFVYGDRICDEYVFAFAILAVVFFF 278
            |:..|.|||:|.||...|...|..:|.:|..||.|...||:||:|::..|.: |||.||.:|.||
  Rat   249 GIGLQFLLGLLILRTRPGFVAFDWMGKQVQTFLGYTDAGAQFVFGEKYTDHF-FAFKILPIVVFF 312

  Fly   279 SVITSIMYYLGWMQFILNGFGFLLQAMVGTTVCESVNAAGNVFLSMTESPLVIRPYIEILTVSEL 343
            |.:.|::||||.||:|:...|:|:...:|::..|||.||||:|:..|||||:::||:..:|.|||
  Rat   313 STVMSMLYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFVGQTESPLLVQPYLPHVTKSEL 377

  Fly   344 HAICTSGYATVAGTVLGAYVSFGASASFLIAASVMAAPGSLAFAKLFYPETEE-SLTRSDNIKLE 407
            |.|.|:|:||:||:|||||:|||.|::.|:.||||:||.:||.||||:||||: .:|..:.:|:|
  Rat   378 HTIMTAGFATIAGSVLGAYISFGVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKNAMKME 442

  Fly   408 SSTDTSILDAAASGAAAALLIVLGIVSNIIAFLAIVFFLDAVTEWIFELIGLHNITLLYILSQIF 472
            :....::|:||..||::::.:|..|.:|:|||||::.|:::...|...:.....::...|.|.||
  Rat   443 NGDSRNLLEAATQGASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFDYPQLSFELICSYIF 507

  Fly   473 IPIVFVMGVPWHDCQAIGLVVAQKSFINEFVAYRNLGILVSDKK-------------VDPRSAAI 524
            :|..|:|||.|.|...:..::..|:|.||||||.:|...::.:|             :..||..|
  Rat   508 MPFSFMMGVDWQDSFMVAKLIGYKTFFNEFVAYEHLSKFINLRKAAGPKFVNGVQQYMSIRSETI 572

  Fly   525 ATFALCGFANPGSLGIVIASLSAMAPSRRSDITRVAFRSYFAGSFVSFTSASLAGIL 581
            ||:|||||||.|||||||..|:::||||:.||...|.|:..||:...|.:|.:||:|
  Rat   573 ATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAGTIACFMTACIAGML 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNT1	NP_610447.2	nupC	184..581	CDD:273278	178/410 (43%)
		Nucleos_tra2_N	188..257	CDD:280026	28/68 (41%)
		Gate	271..366	CDD:284976	50/94 (53%)
		Nucleos_tra2_C	372..581	CDD:284970	90/222 (41%)
Slc28a3	NP_543184.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
Slc28a3	NP_543184.2	nupC	218..629	CDD:273278	178/411 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350956
Domainoid	1	1.000	191	1.000	Domainoid score	I3137
eggNOG	1	0.900	-	-		E1_COG1972
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2019
OMA	1	1.010	-	-		QHG63093
OrthoDB	1	1.010	-	-		D251221at33208
OrthoFinder	1	1.000	-	-		FOG0001233
OrthoInspector	1	1.000	-	-		mtm9124
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10590
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X691
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870