DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNT1 and Slc28a1

DIOPT Version :9

Sequence 1:	NP_610447.2	Gene:	CNT1 / 35915	FlyBaseID:	FBgn0033371	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_446315.1	Gene:	Slc28a1 / 116642	RGDID:	621223	Length:	648	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	198/535 - (37%)
Similarity:	318/535 - (59%)	Gaps:	55/535 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 PEVKPKLLCQ-----INW-CHG------YGFLIVLFIL-------------FYILWLYYWVFKPF 130
            |.|:.:..|:     ..| |.|      .|||:|..:|             ..:::|.|.:.|..
  Rat    67 PTVQARSFCREHRQLFGWICKGLLSTACLGFLMVACLLDLQRALALLIITCVVLVFLAYDLLKRL 131

  Fly   131 VGIKLYNNYLEPVIDKWIAFSRQ-----WIVSGVMLAIVLAVVVAYLGFECRNDAYKAIGLLGPV 190
            :|.||         .:.:.|...     |:..|:.||..:.::: :|..:......:.:...|..
  Rat   132 LGSKL---------RRCVKFQGHSCLSLWLKRGLALAAGVGLIL-WLSLDTAQRPEQLVSFAGIC 186

  Fly   191 CFVLIGFAVSKHHLQVPWRIVTHGLLGQLLLGILCLRLPFGRSIFQCLGDKVTIFLNYAQHGARF 255
            .|:::.||.||||..|.||.|:.||..|.:||:..:|...|...||.|||::.:||:|.:.|:.|
  Rat   187 VFLVLLFAGSKHHRAVSWRAVSWGLGLQFVLGLFVIRTEPGFIAFQWLGDQIQVFLSYTEAGSSF 251

  Fly   256 VYGDRICDEYVFAFAILAVVFFFSVITSIMYYLGWMQFILNGFGFLLQAMVGTTVCESVNAAGNV 320
            |:|:.:..: ||||.:|.::.|||.:.|::||||.||:::....:|:|..:||:..|:::.|||:
  Rat   252 VFGEALVKD-VFAFQVLPIIIFFSCVMSVLYYLGLMQWVILKIAWLMQVTMGTSATETLSVAGNI 315

  Fly   321 FLSMTESPLVIRPYIEILTVSELHAICTSGYATVAGTVLGAYVSFGASASFLIAASVMAAPGSLA 385
            |:|.||:||:||||:..:|:||:|.:.|.||||:||::||||:|||..|:.||||||||||.:||
  Rat   316 FVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDAASLIAASVMAAPCALA 380

  Fly   386 FAKLFYPETEESLTRSDN-IKLESSTDTSILDAAASGAAAALLIVLGIVSNIIAFLAIVFFLDAV 449
            .:||.|||.|||..||:| :||......::|:||::|||.::.:|..|.:|:|||||::.|::|.
  Rat   381 LSKLVYPEVEESKFRSENGVKLTYGDAQNLLEAASAGAAISVKVVANIAANLIAFLAVLAFVNAA 445

  Fly   450 TEWIFELIGLHNITLLYILSQIFIPIVFVMGVPWHDCQAIGLVVAQKSFINEFVAYRNLGIL--- 511
            ..|:.:::.:..::...|.|.:..|:.|:|||.|.||..:..::..|.|:||||||:.|...
  Rat   446 LSWLGDMVDIQGLSFQLICSYVLRPVAFLMGVAWEDCPVVAELLGIKFFLNEFVAYQELSQYKQR 510

  Fly   512 --------VSDKK--VDPRSAAIATFALCGFANPGSLGIVIASLSAMAPSRRSDITRVAFRSYFA 566
                    :.|||  :..|:..:.|:|||||||..|:||::..|:::.|.||||.:::..|:...
  Rat   511 RLAGAEEWLGDKKQWISVRAEILTTYALCGFANFSSIGIMLGGLTSLVPQRRSDFSQIVLRALIT 575

  Fly   567 GSFVSFTSASLAGIL 581
            |:|||..:|.:||||
  Rat   576 GAFVSLLNACVAGIL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNT1	NP_610447.2	nupC	184..581	CDD:273278	173/410 (42%)
		Nucleos_tra2_N	188..257	CDD:280026	29/68 (43%)
		Gate	271..366	CDD:284976	45/94 (48%)
		Nucleos_tra2_C	372..581	CDD:284970	90/222 (41%)
Slc28a1	NP_446315.1	nupC	179..590	CDD:273278	173/411 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350954
Domainoid	1	1.000	191	1.000	Domainoid score	I3137
eggNOG	1	0.900	-	-		E1_COG1972
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2019
OMA	1	1.010	-	-		QHG63093
OrthoDB	1	1.010	-	-		D251221at33208
OrthoFinder	1	1.000	-	-		FOG0001233
OrthoInspector	1	1.000	-	-		mtm9124
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10590
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X691
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870