DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNT2 and Slc28a2

DIOPT Version :9

Sequence 1:	NP_610446.1	Gene:	CNT2 / 35914	FlyBaseID:	FBgn0025709	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_113852.2	Gene:	Slc28a2 / 60423	RGDID:	61840	Length:	659	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	219/606 - (36%)
Similarity:	343/606 - (56%)	Gaps:	66/606 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSKGAINNGYELDHKELDI------RDSEEFTE-HPLDD-----------TSEVANKKGYFEKNP 51
            |..|..|.|.||    :::      :..||.|: |.|.|           .......:.:::::.
  Rat    15 SENGMENPGLEL----MEVGNLEQGKTLEEVTQGHSLKDGLGHSSLWRRILQPFTKARSFYQRHA 75

  Fly    52 KVARLVRISIYVLLHLCVVGYFSYATYHYHDITNYECYWKDNPLCGINFCTGYGMLLLLLGFIYL 116
            .:.:.:.:.:     ||:    :||.|..             ..|.:||.....:.::....|::
  Rat    76 GLFKKILLGL-----LCL----AYAAYLL-------------AACILNFRRAQALFVITCLVIFI 118

  Fly   117 GLFYYYVFKPMVGHSLHRNYIKPFSKKWHNFSRTRVVSLASIALLLALLAIFVYFECRDETQKLV 181
             |..:::.|.....|:  ..:||...........||...|::..|:..||:    :.....::|:
  Rat   119 -LACHFLKKFFAKKSI--RCLKPLKNTRLRLWLKRVFMGAAVVGLILWLAL----DTAQRPEQLI 176

  Fly   182 SLVAPCFFILCGYVFSTNRRAINWRIVITGITCQFLLGIFCIRWEVGRKIFECLGNKVATFLGYA 246
            |....|.|||..:..|.:..|::||.|..|:..||:.||..||.|.|...|:.||:::..||.|.
  Rat   177 SFAGICMFILILFACSKHHSAVSWRTVFWGLGLQFVFGILVIRTEPGFNAFQWLGDQIQIFLAYT 241

  Fly   247 TDGAEFVFGDFLVNNNVFAFAILPVIFFFSFFISILYYMGTMQWVVIKLGWILQQILGTTVCESV 311
            .:|:.|||||.|| .:||||..||:|.||...:|||||:|.:|||:.|:.|.||..:|||..|::
  Rat   242 VEGSSFVFGDTLV-QSVFAFQSLPIIIFFGCVMSILYYLGLVQWVIQKIAWFLQITMGTTAAETL 305

  Fly   312 TAAANIFLGMSESPLLIRPYINKLTKSEIHSIMVSGFATVSGTVLAAYLSFGASAAHLITSSVMA 376
            ..|.|||:||:|:|||||||:..:|.||||::|..||||::||||.|::|||..|:.||::||||
  Rat   306 AVAGNIFVGMTEAPLLIRPYLADMTLSEIHAVMTGGFATIAGTVLGAFISFGIDASSLISASVMA 370

  Fly   377 APATLAISKLYMPETEESQ-TSSDSIELEKSQDSSLLDAASSGASNAVPIVLGIIANIVAFVAFI 440
            ||..||:|||..||.|||: .|.:.::|.:.::.::|:|||:||::|:.:|..:.||::||:|.:
  Rat   371 APCALALSKLVYPEVEESKFKSKEGVKLPRGEERNILEAASNGATDAIGLVANVAANLIAFLAVL 435

  Fly   441 AFLNGLVSWFGYLVGLEQIDFEWIFSKLFIPLVWAMGVPKEDCDIIAKVVATKTIINEFVAYERL 505
            ||:|..:||.|.:|.:..:.|:.|.|.:..|:|:.|||...||.::|::|..|..|||||||::|
  Rat   436 AFINSTLSWLGEMVDIHGLTFQVICSYVLRPMVFMMGVQWADCPLVAEIVGVKFFINEFVAYQQL 500

  Fly   506 GQYI-------------ENNDITARSAGIATFAICGFANPSSLGILIGSLSAMAPHRRSTITAVA 557
            .||.             |...|:.::..||||::|||||.:|:||.:|.|::|.|.|:|.:..:.
  Rat   501 SQYKNKRLSGVEEWINGEKQWISVKAEIIATFSLCGFANLTSIGITLGGLTSMVPQRKSDLCKLV 565

  Fly   558 FRAFVVGSIVCFVSASFAGIL 578
            .||...|:.|.|:||..||||
  Rat   566 VRALFTGACVSFISACMAGIL 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNT2	NP_610446.1	nupC	180..578	CDD:273278	185/411 (45%)
		Nucleos_tra2_N	187..254	CDD:280026	26/66 (39%)
		Gate	268..363	CDD:284976	52/94 (55%)
		Nucleos_tra2_C	368..578	CDD:284970	92/223 (41%)
Slc28a2	NP_113852.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		2/6 (33%)
Slc28a2	NP_113852.2	nupC	175..586	CDD:273278	185/411 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350951
Domainoid	1	1.000	191	1.000	Domainoid score	I3137
eggNOG	1	0.900	-	-		E1_COG1972
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2019
OMA	1	1.010	-	-		QHG63093
OrthoDB	1	1.010	-	-		D251221at33208
OrthoFinder	1	1.000	-	-		FOG0001233
OrthoInspector	1	1.000	-	-		mtm9124
orthoMCL	1	0.900	-	-		OOG6_102197
Panther	1	1.100	-	-	O	PTHR10590
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X691
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770