DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNT2 and CNT1

DIOPT Version :9

Sequence 1:	NP_610446.1	Gene:	CNT2 / 35914	FlyBaseID:	FBgn0025709	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_610447.2	Gene:	CNT1 / 35915	FlyBaseID:	FBgn0033371	Length:	590	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	288/581 - (49%)
Similarity:	384/581 - (66%)	Gaps:	43/581 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KGYFEKNPKVARLVRIS---IYVLLHLCVVGYFSYAT--YHYHDITNYECYW------------- 90
            :|..|:.|..:|..||:   ::||||:..:.||:.||  :.::|..:.|| |
  Fly     6 EGEQEEKPPPSRAKRITYLVLHVLLHIIFISYFTAATIIFIFYDKDSKEC-WPNRGSEATTESID 69

  Fly    91 ------------------------KDNPLCGINFCTGYGMLLLLLGFIYLGLFYYYVFKPMVGHS 131
                                    |...||.||:|.|||.|::|....|:...||:||||.||..
  Fly    70 NSTEDDDDDDYDTEETSEKPVPEVKPKLLCQINWCHGYGFLIVLFILFYILWLYYWVFKPFVGIK 134

  Fly   132 LHRNYIKPFSKKWHNFSRTRVVSLASIALLLALLAIFVYFECRDETQKLVSLVAPCFFILCGYVF 196
            |:.||::|...||..|||..:||...:|::||::..::.||||::..|.:.|:.|..|:|.|:..
  Fly   135 LYNNYLEPVIDKWIAFSRQWIVSGVMLAIVLAVVVAYLGFECRNDAYKAIGLLGPVCFVLIGFAV 199

  Fly   197 STNRRAINWRIVITGITCQFLLGIFCIRWEVGRKIFECLGNKVATFLGYATDGAEFVFGDFLVNN 261
            |.:...:.||||..|:..|.||||.|:|...||.||:|||:||..||.||..||.||:||.:.:.
  Fly   200 SKHHLQVPWRIVTHGLLGQLLLGILCLRLPFGRSIFQCLGDKVTIFLNYAQHGARFVYGDRICDE 264

  Fly   262 NVFAFAILPVIFFFSFFISILYYMGTMQWVVIKLGWILQQILGTTVCESVTAAANIFLGMSESPL 326
            .|||||||.|:||||...||:||:|.||:::...|::||.::||||||||.||.|:||.|:||||
  Fly   265 YVFAFAILAVVFFFSVITSIMYYLGWMQFILNGFGFLLQAMVGTTVCESVNAAGNVFLSMTESPL 329

  Fly   327 LIRPYINKLTKSEIHSIMVSGFATVSGTVLAAYLSFGASAAHLITSSVMAAPATLAISKLYMPET 391
            :|||||..||.||:|:|..||:|||:||||.||:||||||:.||.:||||||.:||.:||:.|||
  Fly   330 VIRPYIEILTVSELHAICTSGYATVAGTVLGAYVSFGASASFLIAASVMAAPGSLAFAKLFYPET 394

  Fly   392 EESQTSSDSIELEKSQDSSLLDAASSGASNAVPIVLGIIANIVAFVAFIAFLNGLVSWFGYLVGL 456
            |||.|.||:|:||.|.|:|:||||:|||:.|:.|||||::||:||:|.:.||:.:..|...|:||
  Fly   395 EESLTRSDNIKLESSTDTSILDAAASGAAAALLIVLGIVSNIIAFLAIVFFLDAVTEWIFELIGL 459

  Fly   457 EQIDFEWIFSKLFIPLVWAMGVPKEDCDIIAKVVATKTIINEFVAYERLGQYIENNDITARSAGI 521
            ..|...:|.|::|||:|:.||||..||..|..|||.|:.|||||||..||..:.:..:..|||.|
  Fly   460 HNITLLYILSQIFIPIVFVMGVPWHDCQAIGLVVAQKSFINEFVAYRNLGILVSDKKVDPRSAAI 524

  Fly   522 ATFAICGFANPSSLGILIGSLSAMAPHRRSTITAVAFRAFVVGSIVCFVSASFAGILIQED 582
            ||||:||||||.||||:|.|||||||.|||.||.||||::..||.|.|.|||.||||||.:
  Fly   525 ATFALCGFANPGSLGIVIASLSAMAPSRRSDITRVAFRSYFAGSFVSFTSASLAGILIQNE 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNT2	NP_610446.1	nupC	180..578	CDD:273278	227/397 (57%)
		Nucleos_tra2_N	187..254	CDD:280026	32/66 (48%)
		Gate	268..363	CDD:284976	58/94 (62%)
		Nucleos_tra2_C	368..578	CDD:284970	122/209 (58%)
CNT1	NP_610447.2	nupC	184..581	CDD:273278	227/396 (57%)
		Nucleos_tra2_N	188..257	CDD:280026	33/68 (49%)
		Gate	271..366	CDD:284976	58/94 (62%)
		Nucleos_tra2_C	372..581	CDD:284970	122/208 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45465014
Domainoid	1	1.000	123	1.000	Domainoid score	I5542
eggNOG	1	0.900	-	-		E1_COG1972
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2475
Isobase	1	0.950	-	0	Normalized mean entropy	S5202
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251221at33208
OrthoFinder	1	1.000	-	-		FOG0001233
OrthoInspector	1	1.000	-	-		otm25845
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10590
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4851
SonicParanoid	1	1.000	-	-		X691
	12	11.880