DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNT2 and slc-28.1

DIOPT Version :9

Sequence 1:	NP_610446.1	Gene:	CNT2 / 35914	FlyBaseID:	FBgn0025709	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_503967.1	Gene:	slc-28.1 / 178770	WormBaseID:	WBGene00017867	Length:	568	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	180/569 - (31%)
Similarity:	292/569 - (51%)	Gaps:	47/569 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VANKKGYFEKNPKVARLVRISIYVLLHLCVVGYFSYATYHYHDITNYE-CYWKDNPLCG----IN 99
            |.|||.:..|...:..:.:.|:                  .|:...|: .|.|..|..|    :.
Worm     2 VLNKKVHQNKEKNLISVTKSSL------------------EHNANFYQRIYQKICPFIGPAAIVA 48

  Fly   100 FCTGYGMLLLLLG---------FIYLGLFYY--YVFKPMVGHSLHRNYIKPFSKKWHNFSRTRVV 153
            |...|...|:..|         .||:.||::  :|...:||....:.....|:.|.::|::.|
Worm    49 FLLVYHGYLIAAGIHNYQKASPLIYVTLFFWLCFVINFIVGTKNFKVVYADFAGKLNDFAKRR-- 111

  Fly   154 SLASIALLLALL-AIFVY--FECRDETQKLVSLVAPCFFILCGYVFSTNRRAINWRIVITGITCQ 215
            :...|...||.. |:|.|  .|...|..:|.......||::...|||...|.|||.||.:.:...
Worm   112 AFVPITFKLAFAGALFAYTIVESLSEPTRLTGFGGYVFFVIFMVVFSNRPRKINWNIVTSALIFH 176

  Fly   216 FLLGIFCIRWEVGRKIFECLGNKVATFLGYATDGAEFVFGDFLVNNN------VFAFAILPVIFF 274
            :.|.:..::|..||..|:.|...:...|.||..||:||||......|      ||.|..|..:.:
Worm   177 YCLALIVLKWPTGRWFFDQLSQLIIGLLEYAQVGAKFVFGFIAGPPNICDLAPVFIFTSLQTLIY 241

  Fly   275 FSFFISILYYMGTMQWVVIKLGWILQQILGTTVCESVTAAANIFLGMSESPLLIRPYINKLTKSE 339
            ||..:::|:|.|.:|..:.|..|.::.::|||..|||.:.|..|||.:|:||:|:||:.|||.||
Worm   242 FSAVVALLFYFGIIQIALKKSTWFMKVLIGTTPVESVYSWACTFLGQTEAPLVIKPYLEKLTDSE 306

  Fly   340 IHSIMVSGFATVSGTVLAAYLSFGASAAHLITSSVMAAPATLAISKLYMPETEESQTSSDSIELE 404
            :.:::.|||:...|||.|||::.||....::|:|:::||.:||.|||..||.:|:....:..||:
Worm   307 LFAVLTSGFSCTGGTVFAAYVALGACPESILTASILSAPMSLACSKLMYPEEQETIIKEEDFELD 371

  Fly   405 KSQDSSLLDAASSGASNAVPIVLGIIANIVAFVAFIAFLNGLVSWFGYLVGLEQIDFEWIFSKLF 469
            ...:....|...|.....||.|..|.|.:|..::.:|.|:.:..:.|.|:|.:...|:.:|...|
Worm   372 HENEKGFFDTLCSAGVALVPTVFAIGATLVVVMSLLALLDQIFFYIGDLIGYDGWSFQMLFGYAF 436

  Fly   470 IPLVWAMGVPKEDCD--IIAKVVATKTIINEFVAYERLGQYIENNDITARSAGIATFAICGFANP 532
            .||.:.||:......  ::|:::.:||.:||||||::|||..:...:..:|..:||:|:|||:|.
Worm   437 FPLAYIMGITNNSNQTLLVAQLMGSKTAVNEFVAYDKLGQLQKEGKLDPKSVLVATYALCGFSNF 501

  Fly   533 SSLGILIGSLSAMAPHRRSTITAVAFRAFVVGSIVCFVSASFAGILIQE 581
            .|:||.:..:..:||.|::..:.|..||...|:|.||::|:.|||||.:
Worm   502 GSMGIQMEVIGGLAPGRKTVASKVMLRALCAGAIACFMNATVAGILISD 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNT2	NP_610446.1	nupC	180..578	CDD:273278	142/405 (35%)
		Nucleos_tra2_N	187..254	CDD:280026	23/66 (35%)
		Gate	268..363	CDD:284976	39/94 (41%)
		Nucleos_tra2_C	368..578	CDD:284970	70/211 (33%)
slc-28.1	NP_503967.1	nupC	141..547	CDD:273278	142/405 (35%)
		Nucleos_tra2_N	158..215	CDD:280026	19/56 (34%)
		Gate	239..330	CDD:284976	38/90 (42%)
		Nucleos_tra2_C	336..547	CDD:284970	70/210 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165215
Domainoid	1	1.000	160	1.000	Domainoid score	I2462
eggNOG	1	0.900	-	-		E1_COG1972
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32533
Inparanoid	1	1.050	317	1.000	Inparanoid score	I1514
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63093
OrthoDB	1	1.010	-	-		D251221at33208
OrthoFinder	1	1.000	-	-		FOG0001233
OrthoInspector	1	1.000	-	-		mtm4853
orthoMCL	1	0.900	-	-		OOG6_102197
Panther	1	1.100	-	-	O	PTHR10590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X691
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770