DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNT2 and Slc28a3

DIOPT Version :9

Sequence 1:	NP_610446.1	Gene:	CNT2 / 35914	FlyBaseID:	FBgn0025709	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_543184.2	Gene:	Slc28a3 / 140944	RGDID:	621224	Length:	705	Species:	Rattus norvegicus

Alignment Length:	636	Identity:	222/636 - (34%)
Similarity:	355/636 - (55%)	Gaps:	91/636 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAESSKGAINNGY-ELDHKELDI--------------------RDSEEFT--EHPL------DDT 37
            :|.|.:|.:|..: :.|.:|.:.                    :|..:.|  :.||      ::.
  Rat    26 TAPSDQGRLNEAFQDEDLEEQNAPGNSTVRSRVVQSGEQGRAKQDDRQITIEQEPLGPKEGTEEE 90

  Fly    38 SEVANKKGYFE-KNPKVARLVRISIYVLLH----LCVVGYFSYATYHYHDITNYECYWKDNPLCG 97
            ||...:||:.| |...|....|....:|.|    :.:.|:.:...                ..|.
  Rat    91 SEDERQKGFLERKYDTVCEFCRKHRVILQHTIWAVLLTGFLALVI----------------AACA 139

  Fly    98 INFCTGYGMLLLLLGFIYLGLFYYYVFKPMVGHSLHR--NYIKP---------FSKKWHNFSRTR 151
            :||.....:.::.|..|     ::.|:..::.....|  :.:.|         |..||
  Rat   140 LNFHRALPLFVITLVTI-----FFVVWDRLMAKYEQRIDDVLSPGKRLLERHWFWLKW------- 192

  Fly   152 VVSLASIALLLALLAIFVYFECRDETQKLVSLVAPCFFILCGYVFSTNRRAINWRIVITGITCQF 216
               :...:|:||::........|...|:|:|......:|:..::||.:...:.||.|..||..||
  Rat   193 ---VVWCSLILAVILWLALDTARLGQQQLISFGGLVMYIVLLFLFSKHPTRVYWRPVFWGIGLQF 254

  Fly   217 LLGIFCIRWEVGRKIFECLGNKVATFLGYATDGAEFVFGDFLVNNNVFAFAILPVIFFFSFFISI 281
            |||:..:|...|...|:.:|.:|.|||||...||:||||: ...::.|||.|||::.|||..:|:
  Rat   255 LLGLLILRTRPGFVAFDWMGKQVQTFLGYTDAGAQFVFGE-KYTDHFFAFKILPIVVFFSTVMSM 318

  Fly   282 LYYMGTMQWVVIKLGWILQQILGTTVCESVTAAANIFLGMSESPLLIRPYINKLTKSEIHSIMVS 346
            |||:|.|||::.|:||::...:|::..|||.||.|||:|.:|||||::||:..:||||:|:||.:
  Rat   319 LYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFVGQTESPLLVQPYLPHVTKSELHTIMTA 383

  Fly   347 GFATVSGTVLAAYLSFGASAAHLITSSVMAAPATLAISKLYMPETEESQ-TSSDSIELEKSQDSS 410
            ||||::|:||.||:|||.|:.||:|:|||:|||.||::||:.||||:.: |..:::::|.....:
  Rat   384 GFATIAGSVLGAYISFGVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKNAMKMENGDSRN 448

  Fly   411 LLDAASSGASNAVPIVLGIIANIVAFVAFIAFLNGLVSWFGYLVGLEQIDFEWIFSKLFIPLVWA 475
            ||:||:.|||:::|:|..|.||::||:|.::|:|..:||||.:....|:.||.|.|.:|:|..:.
  Rat   449 LLEAATQGASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFDYPQLSFELICSYIFMPFSFM 513

  Fly   476 MGVPKEDCDIIAKVVATKTIINEFVAYERLGQYIE-------------NNDITARSAGIATFAIC 527
            |||..:|..::||::..||..|||||||.|.::|.             ...::.||..|||:|:|
  Rat   514 MGVDWQDSFMVAKLIGYKTFFNEFVAYEHLSKFINLRKAAGPKFVNGVQQYMSIRSETIATYALC 578

  Fly   528 GFANPSSLGILIGSLSAMAPHRRSTITAVAFRAFVVGSIVCFVSASFAGIL 578
            ||||..||||:||.|:::||.|:..|.:.|.||.:.|:|.||::|..||:|
  Rat   579 GFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAGTIACFMTACIAGML 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNT2	NP_610446.1	nupC	180..578	CDD:273278	184/411 (45%)
		Nucleos_tra2_N	187..254	CDD:280026	26/66 (39%)
		Gate	268..363	CDD:284976	51/94 (54%)
		Nucleos_tra2_C	368..578	CDD:284970	96/223 (43%)
Slc28a3	NP_543184.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		12/69 (17%)
Slc28a3	NP_543184.2	nupC	218..629	CDD:273278	184/411 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350955
Domainoid	1	1.000	191	1.000	Domainoid score	I3137
eggNOG	1	0.900	-	-		E1_COG1972
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32533
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2019
OMA	1	1.010	-	-		QHG63093
OrthoDB	1	1.010	-	-		D251221at33208
OrthoFinder	1	1.000	-	-		FOG0001233
OrthoInspector	1	1.000	-	-		mtm9124
orthoMCL	1	0.900	-	-		OOG6_102197
Panther	1	1.100	-	-	LDO	PTHR10590
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X691
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770