DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNT2 and Slc28a1

DIOPT Version :9

Sequence 1:	NP_610446.1	Gene:	CNT2 / 35914	FlyBaseID:	FBgn0025709	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_446315.1	Gene:	Slc28a1 / 116642	RGDID:	621223	Length:	648	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	196/504 - (38%)
Similarity:	309/504 - (61%)	Gaps:	33/504 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 CTGYGML-----------LLLLGFIYLGLFYYYVFKPMVGHSLHRNYIKPFSKKWHNFSRTRVVS 154
            |.|:.|:           ||::..:.|....|.:.|.::|..|.|      ..|:...|...:..
  Rat    94 CLGFLMVACLLDLQRALALLIITCVVLVFLAYDLLKRLLGSKLRR------CVKFQGHSCLSLWL 152

  Fly   155 LASIALLLAL-LAIFVYFECRDETQKLVSLVAPCFFILCGYVFSTNRRAINWRIVITGITCQFLL 218
            ...:||...: |.:::..:.....::|||....|.|::..:..|.:.||::||.|..|:..||:|
  Rat   153 KRGLALAAGVGLILWLSLDTAQRPEQLVSFAGICVFLVLLFAGSKHHRAVSWRAVSWGLGLQFVL 217

  Fly   219 GIFCIRWEVGRKIFECLGNKVATFLGYATDGAEFVFGDFLVNNNVFAFAILPVIFFFSFFISILY 283
            |:|.||.|.|...|:.||:::..||.|...|:.||||:.|| .:||||.:||:|.|||..:|:||
  Rat   218 GLFVIRTEPGFIAFQWLGDQIQVFLSYTEAGSSFVFGEALV-KDVFAFQVLPIIIFFSCVMSVLY 281

  Fly   284 YMGTMQWVVIKLGWILQQILGTTVCESVTAAANIFLGMSESPLLIRPYINKLTKSEIHSIMVSGF 348
            |:|.||||::|:.|::|..:||:..|:::.|.|||:..:|:|||||||:..:|.||:|.:|..|:
  Rat   282 YLGLMQWVILKIAWLMQVTMGTSATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGY 346

  Fly   349 ATVSGTVLAAYLSFGASAAHLITSSVMAAPATLAISKLYMPETEESQ-TSSDSIELEKSQDSSLL 412
            ||::|::|.||:|||..||.||.:||||||..||:|||..||.|||: .|.:.::|......:||
  Rat   347 ATIAGSLLGAYISFGIDAASLIAASVMAAPCALALSKLVYPEVEESKFRSENGVKLTYGDAQNLL 411

  Fly   413 DAASSGASNAVPIVLGIIANIVAFVAFIAFLNGLVSWFGYLVGLEQIDFEWIFSKLFIPLVWAMG 477
            :|||:||:.:|.:|..|.||::||:|.:||:|..:||.|.:|.::.:.|:.|.|.:..|:.:.||
  Rat   412 EAASAGAAISVKVVANIAANLIAFLAVLAFVNAALSWLGDMVDIQGLSFQLICSYVLRPVAFLMG 476

  Fly   478 VPKEDCDIIAKVVATKTIINEFVAYERLGQYIEN---------ND----ITARSAGIATFAICGF 529
            |..|||.::|:::..|..:||||||:.|.||.:.         .|    |:.|:..:.|:|:|||
  Rat   477 VAWEDCPVVAELLGIKFFLNEFVAYQELSQYKQRRLAGAEEWLGDKKQWISVRAEILTTYALCGF 541

  Fly   530 ANPSSLGILIGSLSAMAPHRRSTITAVAFRAFVVGSIVCFVSASFAGIL 578
            ||.||:||::|.|:::.|.|||..:.:..||.:.|:.|..::|..||||
  Rat   542 ANFSSIGIMLGGLTSLVPQRRSDFSQIVLRALITGAFVSLLNACVAGIL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNT2	NP_610446.1	nupC	180..578	CDD:273278	178/411 (43%)
		Nucleos_tra2_N	187..254	CDD:280026	26/66 (39%)
		Gate	268..363	CDD:284976	46/94 (49%)
		Nucleos_tra2_C	368..578	CDD:284970	90/223 (40%)
Slc28a1	NP_446315.1	nupC	179..590	CDD:273278	178/411 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350953
Domainoid	1	1.000	191	1.000	Domainoid score	I3137
eggNOG	1	0.900	-	-		E1_COG1972
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2019
OMA	1	1.010	-	-		QHG63093
OrthoDB	1	1.010	-	-		D251221at33208
OrthoFinder	1	1.000	-	-		FOG0001233
OrthoInspector	1	1.000	-	-		mtm9124
orthoMCL	1	0.900	-	-		OOG6_102197
Panther	1	1.100	-	-	O	PTHR10590
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X691
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770