DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and Ciita

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_445981.2	Gene:	Ciita / 85483	RGDID:	619813	Length:	1153	Species:	Rattus norvegicus

Alignment Length:	435	Identity:	94/435 - (21%)
Similarity:	143/435 - (32%)	Gaps:	142/435 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLPC-EYNPKECPSPAAEKSRLFTILLLYCWQREYDKRPYRQFQ------FKRLTFEERIGRRYH 62
            |..| |...||.|...|...|              .||||..:.      ...|.|:.|.    |
  Rat   745 LAQCNEMKDKELPQYLALTPR--------------KKRPYDNWLEGVPRFLAGLVFQPRA----H 791

  Fly    63 CI-------------RDLRIIVNYLLR------RPQLSVQISSLVVSNWDAGLLKDFVRSLLPVW 108
            |:             |..:::..||.|      |....:::........:.|:.| .|...||
  Rat   792 CLGALVEPAMAAVADRKRKVLTRYLKRLKLGTLRAGRLLELLHCAHETQEPGIWK-HVSHQLP-- 853

  Fly   109 YIELRLMRFPREFFVMLRLNAAKMNVSQLSLEGTPLTDEDVRILREFLLVSKTLRRLNVSSCSLT 173
                                      ..||..||.||..||.:|.         |.|..:|   .
  Rat   854 --------------------------GHLSFLGTRLTAPDVYVLG---------RALETAS---Q 880

  Fly   174 QFNFALIADGVYKSPGVRRLSANRLLGMSLSLDTEKISSVLSSLLMQNTLWALSLEHCELT---- 234
            .|:..|...|:..|    ||  ..|:|:|.      ::|..:||.....||. ||:|...|
  Rat   881 DFSLDLRQTGIEPS----RL--GDLVGLSC------VTSFRASLSDTMALWE-SLQHQGETQLLQ 932

  Fly   235 -AQDMIPIAEHLARTNS-----------------------------KFRRLRIACNKI-GPDGAF 268
             |::...|....|::..                             ..::|..|...: ||....
  Rat   933 AAEEKFTIEPFKAKSPKDVEDLDSLVQTQRLRNPSADAAKDLPAIRDLKKLEFALGPVLGPQAFP 997

  Fly   269 FLLRGMSMGGNLELLDLSYCSIGTHGGEWVAKYLAS---CRRLQVLHLNYN---DMGPTAVNLIL 327
            .|.:.:....:|:.|||...|....|.:.|:|..|:   .:.|:.|:|:.|   |:|...:...|
  Rat   998 TLAKILPAFSSLQHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEAL 1062

  Fly   328 LAMKKQCKLEKLTLYGNHFDSRTAMIVRRLLDAEVVLHSELDISY 372
            .|:.|  .|.:|:||.|......|..:.|:|...|.|. .:|:.:
  Rat  1063 PALAK--SLLRLSLYNNCICDEGAKSLARVLPDMVSLR-VMDVQF 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	9/26 (35%)
		LRR_RI	137..374	CDD:238064	67/277 (24%)
		leucine-rich repeat	162..189	CDD:275381	7/26 (27%)
		leucine-rich repeat	202..220	CDD:275380	4/17 (24%)
		leucine-rich repeat	223..251	CDD:275380	9/61 (15%)
		leucine-rich repeat	252..279	CDD:275380	5/27 (19%)
		leucine-rich repeat	280..307	CDD:275380	9/29 (31%)
		leucine-rich repeat	308..335	CDD:275380	9/29 (31%)
		leucine-rich repeat	336..357	CDD:275380	6/20 (30%)
Ciita	NP_445981.2	NACHT	441..610	CDD:283404
		LRR_RI	812..1137	CDD:238064	76/350 (22%)
		leucine-rich repeat	980..997	CDD:275381	4/16 (25%)
		leucine-rich repeat	1012..1039	CDD:275380	8/26 (31%)
		leucine-rich repeat	1040..1068	CDD:275380	9/29 (31%)
		leucine-rich repeat	1069..1096	CDD:275380	8/26 (31%)
		leucine-rich repeat	1097..1124	CDD:275380	2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900