DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8197 and NLRC5

DIOPT Version :9

Sequence 1:NP_001286225.1 Gene:CG8197 / 35912 FlyBaseID:FBgn0033369 Length:387 Species:Drosophila melanogaster
Sequence 2:NP_001371879.1 Gene:NLRC5 / 84166 HGNCID:29933 Length:1866 Species:Homo sapiens


Alignment Length:428 Identity:101/428 - (23%)
Similarity:160/428 - (37%) Gaps:117/428 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LLPCEYNPKECPSPAAEKSRLFTILLLYCWQREYDKRPYRQFQFKRLTFEERIGRRYHCI--RDL 67
            |..|.:.|:..       |||.|.|             .:..|...||..:      .|:  :.|
Human  1330 LSECSFRPEHV-------SRLATGL-------------SKSLQLTELTLTQ------CCLGQKQL 1368

  Fly    68 RIIVNYLLRRP----QLSVQ---------ISSLVVSNWDAGLLKDFVRSLLPVWYIELRL---MR 116
            .|::: |:.||    .|.||         :|.|.|....:|.:.:     :.:...:.:|   :.
Human  1369 AILLS-LVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTE-----ISISETQQQLCVQLE 1427

  Fly   117 FPRE----FFVMLRLNAAKM----------------NVSQLSLEGTPLTDED--VRILREFLLVS 159
            |||:    ..|.|||....:                .:.||||....|.::|  ..:|.:.||:|
Human  1428 FPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLS 1492

  Fly   160 ----KTLRRLNVSSCSLTQFNFALIADGVYKSPGVRRLSANRLLGMSLSLDTEKISSVLSSLLMQ 220
                ||.|.  .|||..|: ..|.:|.|:.....:..|..:     :...|.|...:::.:|..:
Human  1493 LSELKTFRL--TSSCVSTE-GLAHLASGLGHCHHLEELDLS-----NNQFDEEGTKALMRALEGK 1549

  Fly   221 NTLWALSLEHCELTAQDMIPIAEHLARTNSKFRRLRIACNKIGPDGAFFLLRGMSMGGNLELLDL 285
            ..|..|.|.|..|.:..:..:...|::... .:.||:..|.||..|...|...:....:||.|||
Human  1550 WMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDL 1613

  Fly   286 SYCSIG----------------------------THGGEWVAKYLASCRRLQVLHLNYNDMG-PT 321
            |:..||                            :.||..:|:.|..||||:.|.|..|.:| ||
Human  1614 SHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPT 1678

  Fly   322 AVNLILLAMKKQCKLEKLTLYGNHFDSRTAMIVRRLLD 359
            |:.   ||.:....|..|.|..:|.....|:.:.:.||
Human  1679 ALG---LAQELPQHLRVLHLPFSHLGPGGALSLAQALD 1713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8197NP_001286225.1 leucine-rich repeat 134..161 CDD:275381 10/32 (31%)
LRR_RI 137..374 CDD:238064 68/258 (26%)
leucine-rich repeat 162..189 CDD:275381 8/26 (31%)
leucine-rich repeat 202..220 CDD:275380 3/17 (18%)
leucine-rich repeat 223..251 CDD:275380 6/27 (22%)
leucine-rich repeat 252..279 CDD:275380 7/26 (27%)
leucine-rich repeat 280..307 CDD:275380 13/54 (24%)
leucine-rich repeat 308..335 CDD:275380 10/27 (37%)
leucine-rich repeat 336..357 CDD:275380 5/20 (25%)
NLRC5NP_001371879.1 Atypical_Card 1..95 CDD:408254
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 105..135
NACHT 222..383 CDD:399032
NLRC4_HD2 514..628 CDD:407648
LRR 1 599..622
LRR_RI 690..1069 CDD:423007
LRR 2 713..737
leucine-rich repeat 716..743 CDD:275380
LRR 3 741..765
leucine-rich repeat 744..771 CDD:275380
LRR 4 769..792
leucine-rich repeat 772..799 CDD:275380
leucine-rich repeat 800..826 CDD:275380
leucine-rich repeat 830..871 CDD:275380
LRR 5 869..892
leucine-rich repeat 872..899 CDD:275380
LRR 6 897..921
LRR 7 930..953
LRR 8 976..1000
LRR 9 1004..1026
LRR_RI 1009..1307 CDD:423007
LRR 10 1031..1058
LRR 11 1138..1161
LRR 12 1162..1184
LRR 13 1242..1265
LRR 14 1272..1294
LRR 15 1462..1488 7/25 (28%)
leucine-rich repeat 1465..1495 CDD:275381 10/29 (34%)
LRR 16 1493..1516 8/25 (32%)
leucine-rich repeat 1496..1523 CDD:275381 10/29 (34%)
LRR 17 1521..1544 3/27 (11%)
LRR_RI 1522..1822 CDD:423007 49/201 (24%)
leucine-rich repeat 1524..1545 CDD:275380 3/25 (12%)
leucine-rich repeat 1546..1579 CDD:275380 7/32 (22%)
LRR 18 1554..1577 5/22 (23%)
LRR 19 1578..1600 7/22 (32%)
leucine-rich repeat 1580..1607 CDD:275380 7/26 (27%)
LRR 20 1605..1628 8/22 (36%)
leucine-rich repeat 1608..1635 CDD:275380 8/26 (31%)
LRR 21 1633..1656 2/22 (9%)
leucine-rich repeat 1636..1663 CDD:275380 5/26 (19%)
LRR 22 1661..1684 12/25 (48%)
leucine-rich repeat 1664..1688 CDD:275380 10/26 (38%)
LRR 23 1687..1714 7/27 (26%)
leucine-rich repeat 1690..1717 CDD:275380 7/24 (29%)
LRR 24 1715..1739
leucine-rich repeat 1718..1741 CDD:275380
LRR 25 1741..1762
leucine-rich repeat 1742..1769 CDD:275380
leucine-rich repeat 1770..1789 CDD:275380
LRR 26 1795..1818
leucine-rich repeat 1798..1825 CDD:275380
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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