DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and LRRC31

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_079003.2	Gene:	LRRC31 / 79782	HGNCID:	26261	Length:	552	Species:	Homo sapiens

Alignment Length:	401	Identity:	85/401 - (21%)
Similarity:	147/401 - (36%)	Gaps:	134/401 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 WQREYDKRPYRQFQFKRLTFEERIGRR--YHCI---------RDLRIIVNYLLRRPQLSVQISSL 87
            |:...:|..:         |.:::|::  ..|:         .|::.:|..|...|.|    ..|
Human    68 WRSSMEKNEH---------FLQKLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDL----EEL 119

  Fly    88 VVSNWDAGLLKDFVRSLLPVWYIELRLMRFPREFFVMLRLNAAKMNVSQLSLEGTPLTDEDVRIL 152
            .:| |: |.:...:.|:....::..:|.        :|||.:.:            ||.:||:.|
Human   120 DIS-WN-GFVGGTLLSITQQMHLVSKLK--------ILRLGSCR------------LTTDDVQAL 162

  Fly   153 REFLLVSKTLRRLNVS----------------------------SCSLTQFNFALIADGVYKSPG 189
            .|...:...|..||:|                            .||||.      .||.:....
Human   163 GEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTS------EDGTFLGQL 221

  Fly   190 VRRLSANRLLGMSLSLD-TEKISSVLSSLLMQNTLWALSLEHCELTAQDMIPIAEHLARTNSKFR 253
            :..|.:..:|.:|::.| ...::|:...|...:.|..|.|..|.| :|..:.|.:...|...:.|
Human   222 LPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGL-SQKSVKILDAAFRYLGELR 285

  Fly   254 RLRIACNKIGPDGAFFLLRGMSMGG-------------NLELLDLSYCSIGTHGGEWVAKYLASC 305
            :|.::|||             .:||             :|::|||..||:.......:.:.:...
Human   286 KLDLSCNK-------------DLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLL 337

  Fly   306 RRLQVLHLNYN-DMGPTAVNLI-----LLAMK----KQCKLEKLTLYGNHFDSRTAMIVRRLLDA 360
            ..||.|.|:.| .||.::.||:     |.|:|    ..|.||..|.        ||:       |
Human   338 SNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVINNCALESETF--------TAL-------A 387

  Fly   361 EVVLH-SELDI 370
            |..:| |.|::
Human   388 EASVHLSALEV 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	6/26 (23%)
		LRR_RI	137..374	CDD:238064	66/287 (23%)
		leucine-rich repeat	162..189	CDD:275381	10/54 (19%)
		leucine-rich repeat	202..220	CDD:275380	4/18 (22%)
		leucine-rich repeat	223..251	CDD:275380	8/27 (30%)
		leucine-rich repeat	252..279	CDD:275380	7/39 (18%)
		leucine-rich repeat	280..307	CDD:275380	6/26 (23%)
		leucine-rich repeat	308..335	CDD:275380	12/36 (33%)
		leucine-rich repeat	336..357	CDD:275380	5/20 (25%)
LRRC31	NP_079003.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
		LRR_RI	91..349	CDD:330982	61/303 (20%)
		leucine-rich repeat	91..115	CDD:275380	3/23 (13%)
		leucine-rich repeat	116..143	CDD:275380	6/32 (19%)
		leucine-rich repeat	144..171	CDD:275380	10/46 (22%)
		leucine-rich repeat	172..227	CDD:275380	11/60 (18%)
		LRR 1	227..246		3/18 (17%)
		leucine-rich repeat	228..255	CDD:275380	5/26 (19%)
		LRR_RI	233..>498	CDD:330982	48/195 (25%)
		LRR 2	255..275		7/20 (35%)
		leucine-rich repeat	256..283	CDD:275380	8/27 (30%)
		LRR 3	283..293		3/9 (33%)
		leucine-rich repeat	284..311	CDD:275380	7/39 (18%)
		LRR 4	311..331		6/19 (32%)
		leucine-rich repeat	312..339	CDD:275380	6/26 (23%)
		LRR 5	339..360		9/20 (45%)
		leucine-rich repeat	340..367	CDD:275380	10/26 (38%)
		LRR 6	367..387		8/34 (24%)
		leucine-rich repeat	368..395	CDD:275380	10/41 (24%)
		LRR 7	395..415		1/4 (25%)
		LRR 8	423..443
		leucine-rich repeat	424..453	CDD:275380
		LRR 9	453..475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900