DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and si:ch73-168d20.1

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	XP_009295444.1	Gene:	si:ch73-168d20.1 / 795914	ZFINID:	ZDB-GENE-121214-44	Length:	1388	Species:	Danio rerio

Alignment Length:	357	Identity:	83/357 - (23%)
Similarity:	144/357 - (40%)	Gaps:	63/357 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 DLRI-IVNYLLRRPQLSVQ----------------ISSLVVS----------NWD------AGLL 97
            ||.: ::::||:.||..::                ::|..||          ||:      ..||
Zfish  1039 DLGVNLLSFLLKNPQCKLEKLELEYCCIGAKSCASLASAFVSNPSHLRELNLNWNTPEYPAVKLL 1103

  Fly    98 KDFVRSLLPVWYIE-LRLMR--FPRE--FFVMLRLNAAKMNVSQLSLEGTPLTDEDVRILREFLL 157
            .|:::.  |...:| |:|..  ...|  ..:.|.|.:...::.:|:|......|..|::|.:.|.
Zfish  1104 SDYLKD--PHCKLEKLQLYNCCIGEEGCAALALALISNPSHLRELNLNNNEPGDSGVKLLSDLLK 1166

  Fly   158 VSK-TLRRLNVSSCSLTQFNFALIADGVYKSPG-VRRLSANRLLGMSLSLDTEKISSVLSSLLMQ 220
            ..: .|.:|.:..|.:.:...|.:..|:..:|. :|.|:.||  ....:|..:.:|.:|...|.:
Zfish  1167 DPRCKLEKLQLEYCCIGEEGCAALVSGLKSNPSHLRELNLNR--NEPGNLGAKMLSDLLKDPLFE 1229

  Fly   221 NTLWALSLEHCELTAQDMIPIAEHLARTNSKFRRLRIACNKIGPDGAFFLLRGMSM--------G 277
              |..|.|:.|.:.......:...|....|..|.|.:..||       |:..|:::        .
Zfish  1230 --LEKLELDDCSIENNGFADLVSGLKSNPSNIRELNLNSNK-------FIFSGLNLLCDLLRDQQ 1285

  Fly   278 GNLELLDLSYCSIGTHGGEWVAKYLAS-CRRLQVLHLNYNDMGPTAVNLILLAMKK-QCKLEKLT 340
            ..|..|.|..|:|...|...:|..|.| ...|:.|:||||:.|...|.|:.:.:|. .||||||.
Zfish  1286 CKLRKLQLECCNIDEEGCAALALALISNPSHLRELNLNYNNPGGLGVKLLSVLLKNPHCKLEKLE 1350

  Fly   341 LYGNHFDSRTAMIVRRLLDAEVVLHSELDISY 372
            |............:...|.:......||:::|
Zfish  1351 LSHCSISENYLAALNSALSSNPAHLRELNLNY 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	6/27 (22%)
		LRR_RI	137..374	CDD:238064	62/248 (25%)
		leucine-rich repeat	162..189	CDD:275381	5/26 (19%)
		leucine-rich repeat	202..220	CDD:275380	4/17 (24%)
		leucine-rich repeat	223..251	CDD:275380	5/27 (19%)
		leucine-rich repeat	252..279	CDD:275380	6/34 (18%)
		leucine-rich repeat	280..307	CDD:275380	9/27 (33%)
		leucine-rich repeat	308..335	CDD:275380	10/27 (37%)
		leucine-rich repeat	336..357	CDD:275380	5/20 (25%)
si:ch73-168d20.1	XP_009295444.1	FISNA	203..271	CDD:291170
		NACHT	282..447	CDD:283404
		LRR_RI	<734..890	CDD:238064
		leucine-rich repeat	796..850	CDD:275380
		leucine-rich repeat	824..840	CDD:275381
		leucine-rich repeat	853..881	CDD:275381
		LRR_RI	879..904	CDD:197686
		leucine-rich repeat	882..910	CDD:275381
		leucine-rich repeat	911..939	CDD:275381
		LRR_RI	913..1240	CDD:238064	45/206 (22%)
		leucine-rich repeat	940..965	CDD:275381
		leucine-rich repeat	969..997	CDD:275381
		leucine-rich repeat	998..1026	CDD:275381
		leucine-rich repeat	1027..1050	CDD:275380	3/10 (30%)
		leucine-rich repeat	1056..1084	CDD:275380	3/27 (11%)
		leucine-rich repeat	1085..1113	CDD:275380	6/29 (21%)
		LRR_RI	1105..1384	CDD:238064	70/291 (24%)
		leucine-rich repeat	1114..1142	CDD:275380	6/27 (22%)
		leucine-rich repeat	1143..1171	CDD:275380	6/27 (22%)
		leucine-rich repeat	1172..1200	CDD:275380	6/27 (22%)
		leucine-rich repeat	1201..1229	CDD:275380	8/29 (28%)
		leucine-rich repeat	1230..1258	CDD:275380	5/27 (19%)
		leucine-rich repeat	1259..1287	CDD:275380	6/34 (18%)
		leucine-rich repeat	1288..1316	CDD:275380	9/27 (33%)
		leucine-rich repeat	1317..1345	CDD:275380	10/27 (37%)
		leucine-rich repeat	1346..1374	CDD:275380	6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900