DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8197 and Lrrc34

DIOPT Version :9

Sequence 1:NP_001286225.1 Gene:CG8197 / 35912 FlyBaseID:FBgn0033369 Length:387 Species:Drosophila melanogaster
Sequence 2:NP_082217.1 Gene:Lrrc34 / 71827 MGIID:1919077 Length:415 Species:Mus musculus


Alignment Length:383 Identity:84/383 - (21%)
Similarity:157/383 - (40%) Gaps:55/383 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 KSRLFTILLLYCWQREYDKRPYRQFQF-----KRLTFEERIGRRYHCIRDLRIIVNYLLRRPQLS 81
            |:..|.:.:|.....|.:|||..:|..     .||...:||..     .|..::...|..:|.:|
Mouse    18 KTNPFILNILQKLDEEIEKRPKEKFTVNIAGNNRLDSGQRITG-----EDFWLLSKTLRNQPCIS 77

  Fly    82 -VQISSLVVSNWDAGLLKDFVRSLLPVWYIELRLMRFPREFFVMLRLN---------AAK----- 131
             |.:...::.  |.|           .:|....|.:.|...::.|..|         .||     
Mouse    78 GVDVRYNLIG--DVG-----------AFYAAKLLQKQPSITYLNLMFNDIGPEGGELIAKALHKN 129

  Fly   132 MNVSQLSLEGTPLTDEDVRILREFLLVSKTLRRLNVSSCSLTQFNFALIADGVYKSPGVRRLSAN 196
            ..:..|.:.|..:.:....:....|.::.:|.:|::..|.|........:..:.::..::.::.|
Mouse   130 KTLKYLRMTGNKIENTGGMLFAAMLQMNSSLEKLDLGDCDLGLQCVIAFSTVLTQNQAIKGINLN 194

  Fly   197 R--LLGMSLSLDTEKISSVLSSLLMQNTLWALSLEHCELTAQD----MIPIAEHLARTNSKFRRL 255
            |  |.|     :.|:.:..:..:|.:|.: .:.|..|:...::    .:..|.:|   ||..|.|
Mouse   195 RPILYG-----EQEESTVHIGHMLKENHV-LVELHMCKHGMKNYGLQQLCNALYL---NSSLRYL 250

  Fly   256 RIACNKIGPDGAFFLLRGMSMGGNLELLDLSYCSIGTHGGEWVAKYLASCRR-LQVLHLNYNDMG 319
            .::||||..||..||...:.....||:||||:..|.|.|.:::::.|.|..| |:.|.:..|.:.
Mouse   251 DVSCNKITRDGMVFLADVLKSNTTLEVLDLSFNRIETAGAKYLSETLTSHNRSLKALSVVSNKIE 315

  Fly   320 PTAVNLILLAMKKQCKLEKLTLYGNHFDSRTAMIVRRLLDAEVVLHSELDIS-YTYDE 376
            ...:..:..:||....|..:.::||.||..|.:....|:.:..:.....|:. |..||
Mouse   316 GEGLVALSQSMKTNLVLSNIYIWGNKFDEDTCVAYSDLIKSGRLKPDNTDVEPYMVDE 373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8197NP_001286225.1 leucine-rich repeat 134..161 CDD:275381 3/26 (12%)
LRR_RI 137..374 CDD:238064 56/244 (23%)
leucine-rich repeat 162..189 CDD:275381 4/26 (15%)
leucine-rich repeat 202..220 CDD:275380 2/17 (12%)
leucine-rich repeat 223..251 CDD:275380 5/31 (16%)
leucine-rich repeat 252..279 CDD:275380 10/26 (38%)
leucine-rich repeat 280..307 CDD:275380 11/26 (42%)
leucine-rich repeat 308..335 CDD:275380 5/26 (19%)
leucine-rich repeat 336..357 CDD:275380 6/20 (30%)
Lrrc34NP_082217.1 LRR_RI 70..347 CDD:238064 65/298 (22%)
leucine-rich repeat 79..103 CDD:275380 5/36 (14%)
leucine-rich repeat 104..131 CDD:275380 4/26 (15%)
leucine-rich repeat 132..159 CDD:275380 3/26 (12%)
leucine-rich repeat 160..187 CDD:275380 4/26 (15%)
leucine-rich repeat 188..218 CDD:275380 7/34 (21%)
leucine-rich repeat 219..246 CDD:275380 5/29 (17%)
LRR_8 245..314 CDD:290566 26/68 (38%)
LRR 1 246..272 10/25 (40%)
leucine-rich repeat 247..274 CDD:275380 10/26 (38%)
LRR 2 274..296 9/21 (43%)
leucine-rich repeat 275..303 CDD:275380 11/27 (41%)
leucine-rich repeat 304..325 CDD:275380 3/20 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4308
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 61 1.000 Inparanoid score I5394
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53944
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - oto92635
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.960

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