DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8197 and Nlrp4f

DIOPT Version :9

Sequence 1:NP_001286225.1 Gene:CG8197 / 35912 FlyBaseID:FBgn0033369 Length:387 Species:Drosophila melanogaster
Sequence 2:XP_038951886.1 Gene:Nlrp4f / 691086 RGDID:1588619 Length:940 Species:Rattus norvegicus


Alignment Length:390 Identity:88/390 - (22%)
Similarity:151/390 - (38%) Gaps:97/390 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 CDVLLPCEYNPKECPSPAAEKSRLFTILLLYCWQREYD-------KRPYRQFQFKRLTFEERIGR 59
            |..|....::.:...:...|:.  :...||.||.   |       .:..:..|.|...|.|...|
  Rat   594 CSTLKKLSFSTQNALNEELEQQ--YRERLLICWN---DICSVFVRSKNIQTLQIKDTNFSEPTFR 653

  Fly    60 RYHCIRDLRIIVNYLLRRPQLSVQISSLVVSN----WDAGLLKDFVRSLLPVWYIELRLMRFPRE 120
                      ::...|:.|  |..:|.||.:|    .|..:..:.::: ..:.|::|........
  Rat   654 ----------VLYESLKYP--SFPLSKLVANNVHFFGDNHMFFELIQN-HNLQYLDLSCSSLSPN 705

  Fly   121 FFVML--RLNAAKMNVSQLSLEGTPLTDEDVRILREFLLVSKTLRRLNVSSCSLTQFNFALIADG 183
            ...:|  .||.|:.|:.:|.:....|:.:|.:|....|:.||||:.||::|.:|.|         
  Rat   706 GVKLLFDVLNQAECNIEKLMVAHCKLSPDDCKIFGSILMSSKTLKILNLASNNLNQ--------- 761

  Fly   184 VYKSPGVRRLSANRLLGMSLSLDTEKISSVLSSLLMQN-TLWALSLEHCELTAQDMIPIAEHLAR 247
                                     .|||:...|...| .|..|.|.:|.|:.|....:::.| |
  Rat   762 -------------------------GISSLCEGLCHPNCVLEYLVLANCSLSEQCWDYLSDVL-R 800

  Fly   248 TNSKFRRLRIACNKIGPDGAFFLLRGMSMGG-NLELLDLSYCSIGTHGGEWVAKYLASCRRLQVL 311
            .|.....|.|:||.:...|...|.:.:::.. .::.|.|.:|.|.|.|.:.:|:.|.:.:.|:.|
  Rat   801 KNKTLNHLDISCNDLKDKGIKILCKALTLPDCFMKSLCLKHCQITTRGCQDLAEVLRNNQNLKHL 865

  Fly   312 HLNYNDMGPTAVNLILLAMKK----------------------------QCK-LEKLTLYGNHFD 347
            |::.|.:....|.|:..|:|.                            ||| |::|||.||.|:
  Rat   866 HVSNNKLKDAGVKLLCDAIKHPNCHLVDLGLEACEITGASSENLSFAFIQCKTLKRLTLKGNAFE 930

  Fly   348  347
              Rat   931  930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8197NP_001286225.1 leucine-rich repeat 134..161 CDD:275381 6/26 (23%)
LRR_RI 137..374 CDD:238064 60/242 (25%)
leucine-rich repeat 162..189 CDD:275381 6/26 (23%)
leucine-rich repeat 202..220 CDD:275380 4/17 (24%)
leucine-rich repeat 223..251 CDD:275380 9/27 (33%)
leucine-rich repeat 252..279 CDD:275380 6/27 (22%)
leucine-rich repeat 280..307 CDD:275380 8/26 (31%)
leucine-rich repeat 308..335 CDD:275380 9/54 (17%)
leucine-rich repeat 336..357 CDD:275380 7/12 (58%)
Nlrp4fXP_038951886.1 Pyrin_NALPs 10..93 CDD:260032
NACHT 148..316 CDD:399032
NOD2_WH 393..449 CDD:407651
NLRC4_HD2 451..564 CDD:407648
leucine-rich repeat 637..664 CDD:275381 7/38 (18%)
leucine-rich repeat 666..689 CDD:275381 5/22 (23%)
LRR_RI 692..929 CDD:423007 66/271 (24%)
leucine-rich repeat 692..720 CDD:275380 6/27 (22%)
leucine-rich repeat 721..746 CDD:275380 5/24 (21%)
leucine-rich repeat 749..774 CDD:275380 10/58 (17%)
leucine-rich repeat 777..804 CDD:275380 9/27 (33%)
leucine-rich repeat 805..831 CDD:275380 6/25 (24%)
leucine-rich repeat 834..861 CDD:275380 8/26 (31%)
leucine-rich repeat 862..882 CDD:275380 6/19 (32%)
leucine-rich repeat 891..918 CDD:275380 2/26 (8%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000189
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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