DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and Lrrc45

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	XP_038942780.1	Gene:	Lrrc45 / 688318	RGDID:	1590053	Length:	736	Species:	Rattus norvegicus

Alignment Length:	270	Identity:	70/270 - (25%)
Similarity:	113/270 - (41%)	Gaps:	37/270 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 AAKMNVSQLSLEGTPLTDEDV-----RILREFLLVSKTLRRLNVSSCSLTQFNFALIADGVYKSP 188
            |....:.|||..|..||.:.:     |.|.:.|.....|:.|.:|.|.|::....|:..|:..:.
  Rat    83 AVLQQLHQLSRGGLDLTTQSLTVDTCRALGKLLHKETLLKELVLSDCMLSEEGSTLLLQGLCANT 147

  Fly   189 GVRRLSANRLLGMSLSLDTEKISSVLSSLLMQN-TLWALSLEHCELTAQDMIPIAEHLA------ 246
            .|:.|.   |.|.:|....   :..|..||.|| ::.:|:||...|...:     |..|
  Rat   148 SVQLLD---LKGNNLRATG---AEALGKLLRQNKSIQSLTLEWNNLGTWE-----EAFATFCGGL 201

  Fly   247 RTNSKFRRLRIACNKIGPDGAFFLLRGMSMGGNLELLDLSYCSIGTHGGEWVAKYLASCRRLQVL 311
            ..|...|:|.:..|:|...||..|...:.....|:.|||.:.:||..||..:...|.|.|.|..|
  Rat   202 AANGTLRQLDLRNNQISHKGAEELALALKGNATLQQLDLRWNNIGLLGGRALVNCLPSNRTLWKL 266

  Fly   312 HLNYNDMGPTAVNLILLAMKKQCKLEKLTLYGNHFDSRTAMIVRRLLDAEVV-LHSE-----LDI 370
            .|..|::....:..:..||..  ..:::|.:..: .:||     ::|..||. |..|     ||:
  Rat   267 DLAGNNIPGDILRAVEQAMDH--NQDRITAFREN-QTRT-----KILSKEVQHLQEEKSKQFLDL 323

  Fly   371 SYTYDEALQD 380
            ..|.|:..::
  Rat   324 METIDKQREE 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	9/31 (29%)
		LRR_RI	137..374	CDD:238064	66/254 (26%)
		leucine-rich repeat	162..189	CDD:275381	7/26 (27%)
		leucine-rich repeat	202..220	CDD:275380	4/17 (24%)
		leucine-rich repeat	223..251	CDD:275380	7/33 (21%)
		leucine-rich repeat	252..279	CDD:275380	7/26 (27%)
		leucine-rich repeat	280..307	CDD:275380	10/26 (38%)
		leucine-rich repeat	308..335	CDD:275380	6/26 (23%)
		leucine-rich repeat	336..357	CDD:275380	3/20 (15%)
Lrrc45	XP_038942780.1	leucine-rich repeat	177..203	CDD:275380	6/30 (20%)
		leucine-rich repeat	207..234	CDD:275380	7/26 (27%)
		leucine-rich repeat	235..262	CDD:275380	10/26 (38%)
		SMC_prok_B	<330..674	CDD:274008	0/4 (0%)
		LRR_RI	<96..290	CDD:423007	53/206 (26%)
		leucine-rich repeat	96..120	CDD:275380	5/23 (22%)
		leucine-rich repeat	121..148	CDD:275380	7/26 (27%)
		leucine-rich repeat	149..176	CDD:275380	10/32 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900