DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and Lrrc74a

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_001182696.1	Gene:	Lrrc74a / 627607	MGIID:	3646959	Length:	487	Species:	Mus musculus

Alignment Length:	415	Identity:	89/415 - (21%)
Similarity:	157/415 - (37%)	Gaps:	107/415 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DVLLPCEYNPKECPSPAAEKSRLFTILLLYCWQREYDKRPYRQFQFKRLTFEE-----RIGRRYH 62
            ||.|.||  .:..||...|||.                   |:.....|..|:     .||::..
Mouse    27 DVTLYCE--AEVLPSVEKEKSA-------------------REDSETDLEIEDTEKFFNIGQKEL 70

  Fly    63 CIRDLRII----VNYLLRR--------------PQLSVQISSLVVSNWDAGLLKDFVRSLLPVWY 109
            .:...:::    .:|.:|.              |..:..|:..:|||  ..:||
Mouse    71 YLEACKLVGVVPASYFIRNMEESCVNLNHHGLGPMGTKAIAITLVSN--TTVLK----------- 122

  Fly   110 IEL-----------RLMRFPREFFVMLRLNAAKMNVSQLSLEGTPLTDEDVRILREFLLV-SKTL 162
            :||           .||....|.:.:..||.:..|   |.|||       .||:..||.. :.:|
Mouse   123 LELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNN---LGLEG-------ARIISNFLQENNSSL 177

  Fly   163 RRLNVSSCSLTQFNFALIADGVYKSPGVRRLSANRLLGMSLSLDTEKISSV----LSSLLMQNT- 222
            .:|.:|..|..:...||:...:..:..:|          ||:|...:.|.:    |..:|..|.
Mouse   178 WKLKLSGNSFKEECAALLCQALSSNYRIR----------SLNLSHNEFSDIGGEHLGQMLALNVG 232

  Fly   223 LWALSLEHCELTAQDMIPIAEHLARTNSKFRRLRIACNKIGPDGAFFLLRGMSMGGNLELLDLSY 287
            |.:|:|.......:..:.:...| |:|...::|.::.|..|.:||..|...:.:...|..:|:|.
Mouse   233 LQSLNLSWNHFNIRGAVALCNGL-RSNVTLKKLDVSMNGFGNEGALALGDALRLNSCLVYVDVSR 296

  Fly   288 CSIGTHGGEWVAKYLASCRRLQVLHLNYNDMGPTAVNLILLAMKK--QCKLEKLTLYGNHFDSRT 350
            ..|...|...::|.|.:...||||.|..|.:.......:::|:|:  :.::|.:       |...
Mouse   297 NGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRNPKSRMEDI-------DISN 354

  Fly   351 AMIVR---RLLDAEVVLHSELDISY 372
            .::..   ::||....:|.:||:.|
Mouse   355 VLVSEQFVKVLDGVCAIHPQLDVVY 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	8/27 (30%)
		LRR_RI	137..374	CDD:238064	57/247 (23%)
		leucine-rich repeat	162..189	CDD:275381	6/26 (23%)
		leucine-rich repeat	202..220	CDD:275380	6/21 (29%)
		leucine-rich repeat	223..251	CDD:275380	6/27 (22%)
		leucine-rich repeat	252..279	CDD:275380	6/26 (23%)
		leucine-rich repeat	280..307	CDD:275380	7/26 (27%)
		leucine-rich repeat	308..335	CDD:275380	8/28 (29%)
		leucine-rich repeat	336..357	CDD:275380	2/23 (9%)
Lrrc74a	NP_001182696.1	LRR_RI	73..333	CDD:393385	64/293 (22%)
		leucine-rich repeat	148..176	CDD:275380	11/37 (30%)
		leucine-rich repeat	177..204	CDD:275380	6/26 (23%)
		leucine-rich repeat	205..232	CDD:275380	8/36 (22%)
		leucine-rich repeat	233..257	CDD:275380	4/24 (17%)
		leucine-rich repeat	261..284	CDD:275380	6/22 (27%)
		leucine-rich repeat	285..313	CDD:275380	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900