DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and nlrx1

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	XP_021322089.1	Gene:	nlrx1 / 557335	ZFINID:	ZDB-GENE-071119-3	Length:	1005	Species:	Danio rerio

Alignment Length:	305	Identity:	64/305 - (20%)
Similarity:	118/305 - (38%)	Gaps:	65/305 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 IVNYLLRR--PQLSVQISSLVVSNWDAGLLKDFV----RSLLPVWYIELRLMRFPREFFVMLRLN 128
            :::|..||  .||...|.|..||.....|.|:.:    ::..|...::|.::.:.   |...||.
Zfish   649 LLHYGNRRLLDQLGCNIKSHTVSQITRALRKNLIKQSQKNQPPEELMDLLVLLYE---FQNPRLT 710

  Fly   129 AAKM-NVSQLSLEGTPLTDEDVRILREFL---LVSKTLRRLNVSSCSLTQFNFALIADGVYKSPG 189
            |..: ::..|:|....:|.....:|...|   ..|..|..||:|||.:|.
Zfish   711 AEVLQSIKSLNLSTVRMTPHKCFVLSTVLGCTTSSFHLNELNLSSCHITP--------------- 760

  Fly   190 VRRLSANRLLGMSLSLDTEKISSVLSSLLMQNTLWA-------LSLEHCELTAQDMIPIAEHLAR 247
                   .||.|                     ||.       |:|:...|..:..|.:.:.|..
Zfish   761 -------ELLQM---------------------LWPAFRHTRNLNLQFNSLDPESCILLRDLLLE 797

  Fly   248 TNSKFRRLRIACNKIGPDGAFFLLRGMSMGGNLELLDLSYCSIGTHGGEWVAKYLASCRRLQVLH 312
            .|...:.|::..|.:...|...||..:|...:|:.|:|.:..:.......:|:.|....:|:.|:
Zfish   798 PNCTIKSLQLCDNYLSDSGISHLLEALSGNHSLQRLNLMHTGLSDKSALLLAEKLGQHDQLKELN 862

  Fly   313 LNYNDMGPTAVNLILLAMKKQCKLEKLTLYGNHFD--SRTAMIVR 355
            :.||::|.:|...::.|.::...:..:.||.|...  ::.::.||
Zfish   863 VAYNNIGDSAALTLVDACREHPSIHTVHLYLNQLTDVAKQSLYVR 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	6/29 (21%)
		LRR_RI	137..374	CDD:238064	47/231 (20%)
		leucine-rich repeat	162..189	CDD:275381	7/26 (27%)
		leucine-rich repeat	202..220	CDD:275380	0/17 (0%)
		leucine-rich repeat	223..251	CDD:275380	8/34 (24%)
		leucine-rich repeat	252..279	CDD:275380	6/26 (23%)
		leucine-rich repeat	280..307	CDD:275380	5/26 (19%)
		leucine-rich repeat	308..335	CDD:275380	7/26 (27%)
		leucine-rich repeat	336..357	CDD:275380	5/22 (23%)
nlrx1	XP_021322089.1	P-loop_NTPase	179..338	CDD:328724
		LRR_RI	664..904	CDD:330982	57/285 (20%)
		leucine-rich repeat	717..740	CDD:275380	4/22 (18%)
		leucine-rich repeat	748..777	CDD:275381	12/71 (17%)
		leucine-rich repeat	778..801	CDD:275381	5/22 (23%)
		leucine-rich repeat	802..829	CDD:275381	6/26 (23%)
		leucine-rich repeat	830..857	CDD:275381	5/26 (19%)
		leucine-rich repeat	858..885	CDD:275381	7/26 (27%)
		leucine-rich repeat	886..911	CDD:275381	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900