DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and tonsl

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_001104618.1	Gene:	tonsl / 492655	ZFINID:	ZDB-GENE-041111-230	Length:	1427	Species:	Danio rerio

Alignment Length:	271	Identity:	66/271 - (24%)
Similarity:	115/271 - (42%)	Gaps:	57/271 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PREFFVMLRLNAAKMNVSQLSLEGTPLTDEDVRILREFLLVSKTLRRLNVSSCSLTQFNFALIAD 182
            |.....:||....:.::::|.:....|.||   :|.|.:..:.|:.||.|...|..|    :..:
Zfish  1100 PASLNPLLRALKLQASLTELRISANRLNDE---LLPEMMAAAATMPRLRVLDISANQ----ITGE 1157

  Fly   183 GVYKSPGVRRLSANR----LLGMSLSLD------TEKISSVLSSLLMQNTLWALSLEHCELTAQD 237
            |:.|:.......:..    |..::||::      |:.::|:|||..:   |.:|||:.|.|:|:.
Zfish  1158 GLRKASDAFETRSQAAFPCLEELNLSMNPLGDGWTQALASLLSSCPL---LSSLSLQACGLSARF 1219

  Fly   238 MIPIAEHLARTNSKFRRLRIACNKIGPDGAFFLLRGMSMGGNLELLDLSYCSIGTHGGEWVAKYL 302
               :.:|         ||.:|             ..|:..||:..:.||:.::|:.|.|.|.|.|
Zfish  1220 ---LQQH---------RLLLA-------------NAMASTGNMRSVCLSHNALGSTGFELVLKTL 1259

  Fly   303 -ASCRRLQVLHLNYNDM------GPTAVNLILLAMKKQCKLEKLTLYGNHFDSRTAMIVRRLLDA 360
             ..|    :.||..:.:      .|:...|..|..:..|.|..|.|.||.....:.:::.|.|..
Zfish  1260 PMHC----LTHLELSAVCRGPSDQPSMEILTKLLAQGDCPLTHLNLSGNGLTDHSVLLLARCLPV 1320

  Fly   361 EVVLHSELDIS 371
            ...|.| ||:|
Zfish  1321 CPSLVS-LDLS 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	6/26 (23%)
		LRR_RI	137..374	CDD:238064	63/252 (25%)
		leucine-rich repeat	162..189	CDD:275381	7/26 (27%)
		leucine-rich repeat	202..220	CDD:275380	7/23 (30%)
		leucine-rich repeat	223..251	CDD:275380	8/27 (30%)
		leucine-rich repeat	252..279	CDD:275380	4/26 (15%)
		leucine-rich repeat	280..307	CDD:275380	9/27 (33%)
		leucine-rich repeat	308..335	CDD:275380	5/32 (16%)
		leucine-rich repeat	336..357	CDD:275380	5/20 (25%)
tonsl	NP_001104618.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		TPR_12	27..99	CDD:290160
		TPR 1	27..60
		TPR repeat	27..55	CDD:276809
		TPR_7	29..62	CDD:289919
		TPR repeat	66..96	CDD:276809
		TPR_12	67..143	CDD:290160
		TPR 2	67..100
		TPR repeat	101..142	CDD:276809
		TPR 3	107..147
		TPR_12	162..234	CDD:290160
		TPR 4	162..195
		TPR repeat	162..190	CDD:276809
		TPR repeat	195..231	CDD:276809
		TPR 5	202..235
		TPR_11	206..268	CDD:290150
		TPR 6	242..275
		TPR repeat	242..268	CDD:276809
		TPR_12	309..383	CDD:290160
		TPR 7	311..344
		TPR repeat	316..345	CDD:276809
		TPR repeat	351..381	CDD:276809
		TPR 8	352..385
		TPR repeat	386..418	CDD:276809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..502
		ANK	517..630	CDD:238125
		ANK 1	522..551
		ANK repeat	523..553	CDD:293786
		Ank_2	527..622	CDD:289560
		ANK repeat	555..586	CDD:293786
		ANK 2	555..584
		ANK repeat	591..622	CDD:293786
		ANK 3	591..620
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	692..801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..922
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..961
		LRR_RI	1090..1401	CDD:238064	66/271 (24%)
		LRR 1	1113..1137		6/26 (23%)
		leucine-rich repeat	1116..1143	CDD:275380	7/29 (24%)
		LRR 2	1141..1168		7/30 (23%)
		leucine-rich repeat	1144..1171	CDD:275380	6/30 (20%)
		LRR 3	1174..1197		4/22 (18%)
		leucine-rich repeat	1177..1228	CDD:275380	18/65 (28%)
		LRR 4	1234..1258		8/23 (35%)
		leucine-rich repeat	1237..1263	CDD:275381	8/25 (32%)
		leucine-rich repeat	1264..1295	CDD:275381	5/30 (17%)
		LRR 5	1293..1316		6/22 (27%)
		leucine-rich repeat	1296..1323	CDD:275381	7/26 (27%)
		LRR 6	1321..1346		5/11 (45%)
		leucine-rich repeat	1324..1349	CDD:275381	5/8 (63%)
		LRR 7	1377..1400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900