DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8197 and TONSL

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_038460.4	Gene:	TONSL / 4796	HGNCID:	7801	Length:	1378	Species:	Homo sapiens

Alignment Length:	370	Identity:	79/370 - (21%)
Similarity:	127/370 - (34%)	Gaps:	132/370 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LLPV----------WYIELRLMRFPREFFVMLRLNAAKMNVSQLSLEGTPLTDEDVRILREFLLV 158
            |:||          |..|....|:.:...::.||...|        ||..|..:|        |:
Human   945 LIPVPHSSDTHSVAWLAEQAAQRYYQTCGLLPRLTLRK--------EGALLAPQD--------LI 993

  Fly   159 SKTLRRLNVSSCSLTQFNFALIADGVYKS-----PGVRR--LSANRLLGM-------SLSLDTEK 209
            ...|:..:.....:|.::...:.|...::     .|..:  |.|..|.|:       ||:||..:
Human   994 PDVLQSNDEVLAEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQ 1058

  Fly   210 ISSVLSSLLMQNTLWALSL------EHCELTAQDMIPIAEHLAR--TNSKFRRLRIACNKIGPDG 266
            ::.:|.:|.:...|..|.|      :.|         :||.:|.  |......|.::.|.:||:|
Human  1059 LTPLLRALKLHTALRELRLAGNRLGDKC---------VAELVAALGTMPSLALLDLSSNHLGPEG 1114

  Fly   267 AFFLLRGMSMG-------GNLELLDLSYCSIGTHGGEWVAKYLASC------------------- 305
                ||.::||       .:||.||||...:|...|:.:|..|.:|
Human  1115 ----LRQLAMGLPGQATLQSLEELDLSMNPLGDGCGQSLASLLHACPLLSTLRLQACGFGPSFFL 1175

  Fly   306 -------------RRLQVLHLNYNDMGPTAVNLILLAM--------------------------- 330
                         ..|:.|.|:||.:|..|:...|.::
Human  1176 SHQTALGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVF 1240

  Fly   331 ----KKQCKLEKLTLYGNHFDSRTAMIVRRLLDAEVVLHSELDIS 371
                |:.|.|..|||..||...:....:.|.|.....|.| ||:|
Human  1241 RYLAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLIS-LDLS 1284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	5/26 (19%)
		LRR_RI	137..374	CDD:238064	70/327 (21%)
		leucine-rich repeat	162..189	CDD:275381	3/31 (10%)
		leucine-rich repeat	202..220	CDD:275380	6/17 (35%)
		leucine-rich repeat	223..251	CDD:275380	8/35 (23%)
		leucine-rich repeat	252..279	CDD:275380	9/33 (27%)
		leucine-rich repeat	280..307	CDD:275380	11/58 (19%)
		leucine-rich repeat	308..335	CDD:275380	9/57 (16%)
		leucine-rich repeat	336..357	CDD:275380	6/20 (30%)
TONSL	NP_038460.4	TPR_12	23..99	CDD:290160
		TPR 1	27..60
		TPR repeat	27..55	CDD:276809
		TPR repeat	66..96	CDD:276809
		TPR 2	67..100
		TPR 3	107..147
		TPR repeat	107..131	CDD:276809
		TPR 4	162..195
		TPR repeat	163..190	CDD:276809
		TPR	187..>418	CDD:223533
		TPR repeat	195..231	CDD:276809
		TPR 5	202..235
		TPR 6	242..275
		TPR repeat	242..270	CDD:276809
		TPR repeat	276..300	CDD:276809
		TPR 7	311..344
		TPR repeat	316..339	CDD:276809
		TPR repeat	351..381	CDD:276809
		TPR 8	352..385
		TPR repeat	390..419	CDD:276809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..524
		ANK	523..635	CDD:238125
		ANK repeat	528..559	CDD:293786
		ANK 1	528..557
		Ank_2	533..627	CDD:289560
		ANK repeat	561..592	CDD:293786
		ANK 2	561..590
		ANK repeat	594..627	CDD:293786
		ANK 3	597..626
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..789
		PRR18	707..>919	CDD:292299
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	842..933
		LRR_RI	1045..1306	CDD:238064	57/254 (22%)
		LRR 1	1069..1093		6/32 (19%)
		LRR_8	1072..1141	CDD:290566	23/81 (28%)
		leucine-rich repeat	1072..1099	CDD:275380	8/35 (23%)
		LRR 2	1097..1122		8/28 (29%)
		leucine-rich repeat	1100..1130	CDD:275380	9/33 (27%)
		LRR 3	1128..1151		8/22 (36%)
		leucine-rich repeat	1131..1158	CDD:275380	11/26 (42%)
		leucine-rich repeat	1159..1190	CDD:275380	0/30 (0%)
		LRR 4	1188..1212		8/23 (35%)
		leucine-rich repeat	1191..1215	CDD:275380	8/23 (35%)
		leucine-rich repeat	1216..1249	CDD:275380	1/32 (3%)
		LRR 5	1247..1270		7/22 (32%)
		leucine-rich repeat	1250..1277	CDD:275380	8/26 (31%)
		LRR 6	1275..1300		5/11 (45%)
		leucine-rich repeat	1278..1300	CDD:275380	5/8 (63%)
		leucine-rich repeat	1308..1333	CDD:275380
		LRR 7	1331..1354
		leucine-rich repeat	1334..1355	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900