Protein Alignment CG8197 and Nlrc5

DIOPT Version :10

• Sequence 1: NP_610445.1
• Gene: CG8197 / 35912
• FlyBaseID: FBgn0033369
• Length: 387
• Species: Drosophila melanogaster
• Sequence 2: NP_001028379.2
• Gene: Nlrc5 / 434341
• MGIID: 3612191
• Length: 1915
• Species: Mus musculus
• Alignment Length: 499
• Identity: 99/499 - (19%)
• Similarity: 157/499 - (31%)
• Gaps: 184/499 - (36%)

  Fly     5 LLPCEYNPKECPSPAAEKSRLFTILLLYCWQREYDKRPYR-QFQFKRLTFEERIGRRYHCIRDLR 68
            |..|:..|              |.|...|...|....|.. |...|.|:.:           .|:
Mouse  1113 LQECQLEP--------------TSLTFLCATLEKSPGPLEVQLSCKSLSDD-----------SLK 1152

  Fly    69 IIVNYLLRRPQLS-VQISSLVVSNWDAGLLKDFVRSLLPVWYIELRLM----------------- 115
            |::..|.:.|||| :|:...|:|:....||.|.......|..:.||.:
Mouse  1153 ILLQCLPQLPQLSLLQLRHTVLSSRSPFLLADIFNLCPRVRKVTLRSLCHAVLHFDSNEEQEGVC 1217

  Fly   116 -RFP-----REFFVMLRLNAAKMN-VSQLSLEGTPLTDEDVRILREFLLVSKTLRRLNVSSCSLT 173
             .||     :|....|....:|.| :|||.|....|.|..:|.|.|.|........|::|..:::
Mouse  1218 CGFPGCSLSQEHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNNIS 1282

  Fly   174 QFNFALIADGVYKSPGVRRLSAN-------RL-------LGMSL-----SLDTEKISSVLSSL-- 217
            |.....:.:.:...|.::.:|.:       |:       .|.||     |...|::|.:.|||
Mouse  1283 QEGILYLLETLPSYPNIQEVSVSLSSEQIFRMCFSKKEGAGTSLRLCECSFSPEQVSKLASSLSQ 1347

  Fly   218 -------------------------------------------------LM-------------- 219
                                                             ||
Mouse  1348 AQQLTELWLTKCHLDLPQLTMLLNLVNRPTGLLGLRLEEPWVDSVSLPALMEVCAQASGCLTELS 1412

  Fly   220 ----QNTLW---------------ALSLEHCELTAQD---MIPIAEHLAR--------------- 247
                |..||               ||.|.||:|..:.   ||.:.|..||
Mouse  1413 ISEIQRKLWLQLEFPHQEGNSDSMALRLAHCDLETEHSHLMIQLVETYARLQQLSLSQVSFNDND 1477

  Fly   248 -TNSK-----------FRRLRIACNKIGPDGAFFLLRGMSMGGNLELLDLSYCSIGTHGGEWVAK 300
             |:||           .:..|:..:::.......|..|:....:||.||.|..|:.....|.:..
Mouse  1478 GTSSKLLQNILLSSCELKSFRLTFSQVSTKSLTHLAFGLGHCHHLEELDFSNNSLREEDTELLMG 1542

  Fly   301 YLASCRRLQVLHLNYNDMGPTAVNLILLAMKKQCKLEKLTLYGN 344
            .|....||:.|||::..:|.:::.|::..:.:...|:.|.|..|
Mouse  1543 ALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHN 1586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_610445.1	RNA1	<133..345	CDD:444072	67/346 (19%)
		leucine-rich repeat	202..220	CDD:275380	10/91 (11%)
		leucine-rich repeat	223..251	CDD:275380	14/61 (23%)
		leucine-rich repeat	252..279	CDD:275380	3/26 (12%)
		leucine-rich repeat	280..307	CDD:275380	8/26 (31%)
		leucine-rich repeat	308..335	CDD:275380	6/26 (23%)
		leucine-rich repeat	336..357	CDD:275380	4/9 (44%)
Nlrc5	NP_001028379.2	Atypical_Card	1..94	CDD:436519
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..137
		NACHT	223..>673	CDD:444362
		NACHT	223..385	CDD:428606
		LRR 1	622..646
		RNA1	<640..936	CDD:444072
		LRR 2	716..740
		leucine-rich repeat	719..746	CDD:275380
		LRR 3	744..771
		leucine-rich repeat	747..774	CDD:275380
		LRR 4	772..796
		leucine-rich repeat	775..807	CDD:275380
		leucine-rich repeat	808..838	CDD:275380
		leucine-rich repeat	848..873	CDD:275381
		RNA1	<861..1059	CDD:444072
		LRR 5	871..898
		leucine-rich repeat	874..898	CDD:275381
		leucine-rich repeat	899..929	CDD:275381
		LRR 6	900..923
		leucine-rich repeat	930..977	CDD:275381
		LRR 7	930..953
		leucine-rich repeat	978..1008	CDD:275381
		LRR 8	1006..1033
		PPP1R42	1007..1307	CDD:455733	48/218 (22%)
		leucine-rich repeat	1009..1033	CDD:275381
		LRR 9	1034..1055
		leucine-rich repeat	1037..1061	CDD:275381
		LRR 10	1138..1161		6/33 (18%)
		LRR 11	1162..1184		9/21 (43%)
		LRR 12	1240..1263		9/22 (41%)
		LRR 13	1265..1292		4/26 (15%)
		LRR 14	1348..1371		0/22 (0%)
		RNA1	<1445..1716	CDD:444072	31/142 (22%)
		leucine-rich repeat	1463..1483	CDD:275381	2/19 (11%)
		LRR 15	1481..1504		3/22 (14%)
		leucine-rich repeat	1484..1520	CDD:275381	3/35 (9%)
		LRR 16	1519..1542		7/22 (32%)
		leucine-rich repeat	1522..1549	CDD:275380	8/26 (31%)
		leucine-rich repeat	1550..1574	CDD:275380	6/23 (26%)
		LRR 17	1552..1575		5/22 (23%)
		LRR 18	1576..1598		4/11 (36%)
		leucine-rich repeat	1578..1605	CDD:275380	4/9 (44%)
		RNA1	<1596..1905	CDD:444072
		LRR 19	1603..1626
		leucine-rich repeat	1606..1633	CDD:275380
		LRR 20	1631..1654
		leucine-rich repeat	1634..1661	CDD:275380
		LRR 21	1659..1682
		leucine-rich repeat	1662..1689	CDD:275380
		LRR 22	1687..1711
		leucine-rich repeat	1690..1717	CDD:275380
		LRR 23	1715..1738
		leucine-rich repeat	1718..1743	CDD:275380
		LRR 24	1741..1768
		leucine-rich repeat	1744..1771	CDD:275380
		LRR 25	1769..1795
		leucine-rich repeat	1772..1795	CDD:275380
		leucine-rich repeat	1796..1823	CDD:275380
		LRR 26	1821..1845
		leucine-rich repeat	1824..1843	CDD:275380
		LRR 27	1849..1872