DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8197 and Tonsl

DIOPT Version :9

Sequence 1:NP_001286225.1 Gene:CG8197 / 35912 FlyBaseID:FBgn0033369 Length:387 Species:Drosophila melanogaster
Sequence 2:XP_008763809.1 Gene:Tonsl / 366953 RGDID:1307483 Length:1371 Species:Rattus norvegicus


Alignment Length:244 Identity:64/244 - (26%)
Similarity:97/244 - (39%) Gaps:47/244 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 SSCSL----TQFNFALIADGVYKSPGVRRLSANRL-----------LG-----MSLSLDTEKISS 212
            |:|||    .|....|.|..::.:....|||.|||           ||     :.|.|.:..:..
  Rat  1045 SACSLALCQAQLTPLLRALKLHTALRELRLSGNRLGDPCATELLATLGTMPNLVLLDLSSNHLGP 1109

  Fly   213 VLSSLLMQNTLWALSLEHCELTAQDMIPIAE-------HLARTNSKFRRLRI-ACNKIGPDGAFF 269
            .....|::.:|...:.::.|.....|.|:.:       .|.||....|.||: ||   |...:||
  Rat  1110 EGLRQLVEGSLGQTAFQNVEELDLSMNPLGDGCAQALASLLRTCPVLRTLRLQAC---GFSPSFF 1171

  Fly   270 LLRGMSMGG------NLELLDLSYCSIGTHGGEWVAKYLASCRRLQVLHLNYNDMGPTAVN---- 324
            |....::|.      :|:.|.|||   .|.|...:|:.|.|.....:|||..:.:..:..|    
  Rat  1172 LSHQAALGSAFKDAEHLKTLSLSY---NTLGAPALARVLQSLPTCTLLHLELSSVAASKSNSSLI 1233

  Fly   325 --LILLAMKKQCKLEKLTLYGNHFDSRTAMIVRRLLDAEVVLHSELDIS 371
              :|....|:.|.|..|||..|....:....:.|.|.:...|.| ||:|
  Rat  1234 EPVIKYLTKEGCALAHLTLSANCLSDKAVRELSRCLPSCPSLTS-LDLS 1281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8197NP_001286225.1 leucine-rich repeat 134..161 CDD:275381
LRR_RI 137..374 CDD:238064 64/244 (26%)
leucine-rich repeat 162..189 CDD:275381 7/24 (29%)
leucine-rich repeat 202..220 CDD:275380 3/17 (18%)
leucine-rich repeat 223..251 CDD:275380 7/34 (21%)
leucine-rich repeat 252..279 CDD:275380 10/33 (30%)
leucine-rich repeat 280..307 CDD:275380 10/26 (38%)
leucine-rich repeat 308..335 CDD:275380 6/32 (19%)
leucine-rich repeat 336..357 CDD:275380 5/20 (25%)
TonslXP_008763809.1 TPR 3..271 CDD:223533
TPR repeat 27..55 CDD:276809
TPR repeat 66..96 CDD:276809
TPR repeat 101..131 CDD:276809
TPR repeat 163..190 CDD:276809
TPR 187..464 CDD:223533
TPR repeat 195..237 CDD:276809
TPR repeat 242..270 CDD:276809
TPR repeat 316..339 CDD:276809
TPR repeat 351..381 CDD:276809
TPR repeat 390..417 CDD:276809
ANK 527..639 CDD:238125
ANK repeat 532..563 CDD:293786
Ank_2 537..631 CDD:289560
ANK repeat 565..596 CDD:293786
ANK repeat 601..631 CDD:293786
LRR_RI <1059..1315 CDD:238064 59/230 (26%)
leucine-rich repeat 1069..1096 CDD:275380 8/26 (31%)
leucine-rich repeat 1097..1128 CDD:275380 4/30 (13%)
leucine-rich repeat 1129..1151 CDD:275380 4/21 (19%)
leucine-rich repeat 1156..1187 CDD:275380 10/33 (30%)
leucine-rich repeat 1188..1212 CDD:275380 10/26 (38%)
leucine-rich repeat 1213..1246 CDD:275380 6/32 (19%)
leucine-rich repeat 1247..1274 CDD:275380 7/26 (27%)
leucine-rich repeat 1275..1297 CDD:275380 5/8 (63%)
leucine-rich repeat 1298..1325 CDD:275380
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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