DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and NLRP9

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_789790.2	Gene:	NLRP9 / 338321	HGNCID:	22941	Length:	991	Species:	Homo sapiens

Alignment Length:	262	Identity:	71/262 - (27%)
Similarity:	116/262 - (44%)	Gaps:	21/262 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 AAKMNVSQLSLEGTPLTDEDVRILREFLLVSK-TLRRLNVSSCSLTQFNFALIADGVYKSPGVRR 192
            |....:..|||...||.||.:.:|.|.|..|. .|.||.:..|.||..:...|::.:..|..:..
Human   739 ACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSL 803

  Fly   193 LSANRLLGMSLSLDTEKISSVLSSL----LMQNTLWALSLEHCELTAQDMIPIAEHLARTNSKFR 253
            |.    || |.:|:...::|:.::|    .....||.:.   |.||:.....||..|. .|.|.:
Human   804 LD----LG-SNALEDNGVASLCAALKHPGCSIRELWLMG---CFLTSDSCKDIAAVLI-CNGKLK 859

  Fly   254 RLRIACNKIGPDGAFFLLRGMSMGG-NLELLDLSYCSIGTHGGEWVAKYLASCRRLQVLHLNYND 317
            .|::..|:||..|...|...:.... .||.|.|..|.|.....:.:|..|.:|:.|:.|:|::..
Human   860 TLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIA 924

  Fly   318 MGPTAVNLILLAMK-KQCKLEKLTLYGNHFDSRTAMIVRRLLDAEVVLHSELDISYTYDEALQDY 381
            :...||.::..|:. ..|.|:.|.|:.:.||..|..|:..:  .|.:.|..:......||   :|
Human   925 LDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSV--EEKIPHLTISHGPWIDE---EY 984

  Fly   382 RV 383
            ::
Human   985 KI 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	11/27 (41%)
		LRR_RI	137..374	CDD:238064	67/243 (28%)
		leucine-rich repeat	162..189	CDD:275381	8/26 (31%)
		leucine-rich repeat	202..220	CDD:275380	4/21 (19%)
		leucine-rich repeat	223..251	CDD:275380	9/27 (33%)
		leucine-rich repeat	252..279	CDD:275380	6/27 (22%)
		leucine-rich repeat	280..307	CDD:275380	9/26 (35%)
		leucine-rich repeat	308..335	CDD:275380	6/27 (22%)
		leucine-rich repeat	336..357	CDD:275380	7/20 (35%)
NLRP9	NP_789790.2	Pyrin_NALPs	11..93	CDD:260032
		NACHT	146..314	CDD:310381
		LRR_RI	622..897	CDD:330982	48/166 (29%)
		LRR 1	743..763		7/19 (37%)
		LRR 2	772..793		7/20 (35%)
		LRR 3	800..820		6/24 (25%)
		LRR 4	829..850		6/23 (26%)
		LRR 5	857..877		6/19 (32%)
		LRR 6	886..907		6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000189
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810