DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and Nod2

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	XP_038953498.1	Gene:	Nod2 / 291912	RGDID:	1306368	Length:	1012	Species:	Rattus norvegicus

Alignment Length:	337	Identity:	79/337 - (23%)
Similarity:	127/337 - (37%)	Gaps:	71/337 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 NYLLRR--PQLSVQISSL-----------------VVSNWDAGLLKDFVRSLLPVWYIELR---- 113
            |.||.|  |.|.:|.|.:                 :.:.:.||||....|.||....:..|
  Rat   610 NSLLLRLLPNLCIQGSRVKGGQAALLQKAEPHNLQITAAFLAGLLSQQHRDLLAACQVPERVLLQ 674

  Fly   114 --------LMRFPREFFVMLRLNAAKMNVSQLSLEGTPLTDEDVRILREFLLVSKTLRRLNVSSC 170
                    |....||.|..:.........|..::.|.......:..::|..|..:.:|||::...
  Rat   675 RQARARSCLAHSLREHFHSIPPAVPGETKSMHAMPGFIWLIRSLYEMQEVQLAREAVRRLDIGHL 739

  Fly   171 SLT-------------------------QFNFALIADGVYKSPGVRRLSANRLLGM--SLSLDTE 208
            .||                         |.:...:.|     .||.:|..  .||:  :|.|...
  Rat   740 KLTFCRVGPAECAALAFVLQHLQRPVALQLDHNSVGD-----VGVEQLLP--CLGVCTALYLRDN 797

  Fly   209 KIS-----SVLSSLLMQNTLWALSLEHCELTAQDMIPIAEHLARTNSKFRRLRIACNKIGPDGAF 268
            .||     :::...|....|..|:|.:.:||......:|:.||. ...|..||:..|.|...||.
  Rat   798 NISDRGARTLVECALRCEQLQKLALFNNKLTDGCASSVAKLLAH-KQNFLSLRVGNNHITAAGAE 861

  Fly   269 FLLRGMSMGGNLELLDLSYCSIGTHGGEWVAKYLASCRRLQVLHLNYNDMGPTAVNLILLAMKKQ 333
            .|.:|:....:|:.|.....|:|..|.:.:|:.:|..:||:.|.|..|::|....:.:.|.::|.
  Rat   862 VLAQGLKSNTSLQFLGFWGNSVGDKGSQALAEVVADHQRLKWLSLVGNNIGSVGAHALALMLEKN 926

  Fly   334 CKLEKLTLYGNH 345
            ..||:|.|..||
  Rat   927 KSLEELCLEENH 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	4/26 (15%)
		LRR_RI	137..374	CDD:238064	58/241 (24%)
		leucine-rich repeat	162..189	CDD:275381	7/51 (14%)
		leucine-rich repeat	202..220	CDD:275380	5/22 (23%)
		leucine-rich repeat	223..251	CDD:275380	8/27 (30%)
		leucine-rich repeat	252..279	CDD:275380	9/26 (35%)
		leucine-rich repeat	280..307	CDD:275380	7/26 (27%)
		leucine-rich repeat	308..335	CDD:275380	7/26 (27%)
		leucine-rich repeat	336..357	CDD:275380	6/10 (60%)
Nod2	XP_038953498.1	DD	7..87	CDD:417479
		DD	107..186	CDD:417479
		NACHT	266..436	CDD:399032
		NOD2_WH	518..574	CDD:407651
		NLRC4_HD2	576..729	CDD:407648	24/118 (20%)
		LRR_RI	<752..984	CDD:423007	50/195 (26%)
		leucine-rich repeat	786..816	CDD:275380	7/29 (24%)
		leucine-rich repeat	817..844	CDD:275380	8/27 (30%)
		leucine-rich repeat	845..872	CDD:275380	9/26 (35%)
		leucine-rich repeat	873..900	CDD:275380	7/26 (27%)
		leucine-rich repeat	901..928	CDD:275380	7/26 (27%)
		leucine-rich repeat	929..953	CDD:275380	6/10 (60%)
		leucine-rich repeat	957..978	CDD:275380
		leucine-rich repeat	979..1006	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900