DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and Nlrx1

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_001157214.1	Gene:	Nlrx1 / 270151	MGIID:	2429611	Length:	975	Species:	Mus musculus

Alignment Length:	265	Identity:	59/265 - (22%)
Similarity:	102/265 - (38%)	Gaps:	54/265 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 RSLLP--------VWYIELRLMRFPREFFVMLRLNAAKMNVSQLSLEGTPLTDEDVRILREFLLV 158
            |.:||        .::.|.:..||..|....||         ||:|.|..:|.....::...|..
Mouse   667 RQVLPPSELLDHLFFHYEFQNQRFSAEVLGSLR---------QLNLAGVRMTPLKCTVVASVLGS 722

  Fly   159 SK-TLRRLNVSSCSLTQFNFALIADGVYKSPGVRRLSANRLLGMSLSLDTEKISSVLSSLLMQNT 222
            .: .|..:|::||.|.......:...:.::         |.||:.|:....:....|..||:.
Mouse   723 GRHPLDEVNLASCQLDPAGLHTLMPVLLRA---------RKLGLQLNNLGPEACRDLRDLLLH-- 776

  Fly   223 LWALSLEHCELTAQDMIPIAEHLARTNSKFRRLRIACNKIGPDGAFFLLRGMSMGGNLELLDLSY 287
                  :.|::|.                   ||::.|.:...|...|:.|::...::..|.|.:
Mouse   777 ------DQCQITT-------------------LRLSNNPLTAAGVGLLMDGLAGNTSVTHLSLLH 816

  Fly   288 CSIGTHGGEWVAKYLASCRRLQVLHLNYNDMGPTAVNLILLAMKKQCKLEKLTLYGNHFDSRTAM 352
            ..:|..|.|.:|..|...::||.|::.||..|.|....:..|.::...||.|.||.|...|....
Mouse   817 TDLGDEGLELLAAQLDRNKQLQELNVAYNGAGDTVALALAKAAREHPSLELLHLYFNELSSEGRQ 881

  Fly   353 IVRRL 357
            ::|.|
Mouse   882 VLRDL 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	6/27 (22%)
		LRR_RI	137..374	CDD:238064	49/222 (22%)
		leucine-rich repeat	162..189	CDD:275381	5/26 (19%)
		leucine-rich repeat	202..220	CDD:275380	4/17 (24%)
		leucine-rich repeat	223..251	CDD:275380	2/27 (7%)
		leucine-rich repeat	252..279	CDD:275380	6/26 (23%)
		leucine-rich repeat	280..307	CDD:275380	7/26 (27%)
		leucine-rich repeat	308..335	CDD:275380	8/26 (31%)
		leucine-rich repeat	336..357	CDD:275380	8/20 (40%)
Nlrx1	NP_001157214.1	P-loop_NTPase	161..320	CDD:304359
		LRR_RI	<698..903	CDD:238064	52/234 (22%)
		leucine-rich repeat	698..726	CDD:275380	8/36 (22%)
		leucine-rich repeat	727..748	CDD:275380	5/20 (25%)
		leucine-rich repeat	749..772	CDD:275380	5/31 (16%)
		leucine-rich repeat	773..808	CDD:275380	10/61 (16%)
		leucine-rich repeat	809..836	CDD:275380	7/26 (27%)
		leucine-rich repeat	837..864	CDD:275380	8/26 (31%)
		leucine-rich repeat	865..886	CDD:275380	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900