Protein Alignment CG8197 and Nlrp5

DIOPT Version :10

• Sequence 1: NP_610445.1
• Gene: CG8197 / 35912
• FlyBaseID: FBgn0033369
• Length: 387
• Species: Drosophila melanogaster
• Sequence 2: NP_035990.1
• Gene: Nlrp5 / 23968
• MGIID: 1345193
• Length: 1111
• Species: Mus musculus
• Alignment Length: 384
• Identity: 94/384 - (24%)
• Similarity: 161/384 - (41%)
• Gaps: 83/384 - (21%)

  Fly    23 SRLFTILLLYCWQREYDKR----PYRQFQFKRLTFEERIGRRY------HC---------IRDLR 68
            |.:.|:...||.....|:.    ..::||...|...:::..:.      ||         ||||.
Mouse   590 SPMDTLDAFYCLFESQDEEFVGGALKRFQEVWLLINQKMDLKVSSYCLKHCQNLKAIRVDIRDLL 654

  Fly    69 IIVNYLLRRPQLSV---QISSLVVSNWD-----AGLLK-----DFVRSLL-----PVWYIELR-- 113
            .:.|.|...|.::|   |...|::..|.     .|.|:     |...|:|     .:..:|||
Mouse   655 SVDNTLELCPVVTVQETQCKPLLMEWWGNFCSVLGSLRNLKELDLGDSILSQRAMKILCLELRNQ 719

  Fly   114 -----LMRFPREFFV-----MLRLNAAKMNVSQLSLEGTPLTDEDVRILREFLLVSK-TLRRLNV 167
                 .:.|.....|     :.:|..:..|:..|:|..||:.|:|:::..|.|...| ::..|.:
Mouse   720 SCRIQKLTFKSAEVVSGLKHLWKLLFSNQNLKYLNLGNTPMKDDDMKLACEALKHPKCSVETLRL 784

  Fly   168 SSCSLTQFNFALIADGVYKSPGVRRLSANRLLGMSLSLDTEKISSVL-------SSLLMQNTLWA 225
            .||.||...:.:|:        ...:|..||..:||:.:...:.|::       ||:.:   |..
Mouse   785 DSCELTIIGYEMIS--------TLLISTTRLKCLSLAKNRVGVKSMISLGNALSSSMCL---LQK 838

  Fly   226 LSLEHCELTAQDMIPIAEHL----ARTNSKFRRLRIACNKIGPDGAFFL---LRGMSMGGNLELL 283
            |.|::|.||     |.:.||    ..:|.....|.::.|.:|.:|...|   ||.....  |:.|
Mouse   839 LILDNCGLT-----PASCHLLVSALFSNQNLTHLCLSNNSLGTEGVQQLCQFLRNPECA--LQRL 896

  Fly   284 DLSYCSIGTHGGEWVAKYLASCRRLQVLHLNYNDMGPTAVNLILLAMKK-QCKLEKLTL 341
            .|::|:|......::|..||:..:|..|.|..|.:|..|:.|:..|:|: .|.|::|.|
Mouse   897 ILNHCNIVDDAYGFLAMRLANNTKLTHLSLTMNPVGDGAMKLLCEALKEPTCYLQELEL 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_610445.1	RNA1	<133..345	CDD:444072	62/225 (28%)
		leucine-rich repeat	202..220	CDD:275380	5/24 (21%)
		leucine-rich repeat	223..251	CDD:275380	10/31 (32%)
		leucine-rich repeat	252..279	CDD:275380	7/29 (24%)
		leucine-rich repeat	280..307	CDD:275380	8/26 (31%)
		leucine-rich repeat	308..335	CDD:275380	9/27 (33%)
		leucine-rich repeat	336..357	CDD:275380	3/6 (50%)
Nlrp5	NP_035990.1	NACHT	59..>552	CDD:444362
		NACHT	191..359	CDD:428606
		NLRC4_HD2	496..610	CDD:465499	5/19 (26%)
		LRR	642..>874	CDD:443914	58/247 (23%)
		leucine-rich repeat	694..739	CDD:275380	8/44 (18%)
		leucine-rich repeat	740..755	CDD:275380	3/14 (21%)
		PPP1R42	779..1070	CDD:455733	52/195 (27%)
		leucine-rich repeat	779..806	CDD:275380	7/34 (21%)
		leucine-rich repeat	807..827	CDD:275380	4/19 (21%)
		leucine-rich repeat	836..863	CDD:275380	10/31 (32%)
		leucine-rich repeat	864..892	CDD:275380	7/27 (26%)
		leucine-rich repeat	893..920	CDD:275380	8/26 (31%)
		leucine-rich repeat	921..949	CDD:275380	9/27 (33%)
		leucine-rich repeat	950..977	CDD:275380	3/6 (50%)
		leucine-rich repeat	978..1006	CDD:275380
		leucine-rich repeat	1007..1026	CDD:275380
		leucine-rich repeat	1035..1060	CDD:275381