Protein Alignment CG8197 and Nlrp2

DIOPT Version :10

• Sequence 1: NP_610445.1
• Gene: CG8197 / 35912
• FlyBaseID: FBgn0033369
• Length: 387
• Species: Drosophila melanogaster
• Sequence 2: NP_808358.2
• Gene: Nlrp2 / 232827
• MGIID: 3041206
• Length: 1046
• Species: Mus musculus
• Alignment Length: 299
• Identity: 77/299 - (25%)
• Similarity: 119/299 - (39%)
• Gaps: 64/299 - (21%)

  Fly    78 PQLSVQISSLVVSNWDAGLLKDFVRSLLPVWYIELRLMRFPREFFVMLRLNAAKMNVSQLSLEGT 142
            |.|.|..|.:.:...|..||....:.|..:|                   ...|..:.::|||..
Mouse   791 PVLKVNQSLIFLDLTDNSLLDKSAKLLCNIW-------------------KEPKCILQRVSLENC 836

  Fly   143 PLTDEDVRILREFLLVSKTLRRLNVSSCSLTQFNFALIADGVYKSPGVRRLSANRLLGMSLSLDT 207
            .||:...:.|...|:||:||..|::::..|        .|.     ||:.|             .
Mouse   837 QLTEACCKDLSSVLMVSRTLTHLSLANNKL--------GDN-----GVKNL-------------C 875

  Fly   208 EKISSV---LSSLLMQNTLWALSLEHCELTAQDMIPIAEHLARTNSKFRRLRIACNKIGPDGAFF 269
            |.||..   |.:|:    ||:     |.:|......:::.|.:|.| .:.|.:..|:||..||.|
Mouse   876 ESISCTECNLQTLV----LWS-----CNITNAGCHYLSKMLKQTLS-LKHLDLGLNRIGTKGAKF 930

  Fly   270 LLRGM-SMGGNLELLDLSYCSIGTHGGEWVAKYLASCRRLQVLHLNYNDMGPTAVNLILLAMKKQ 333
            |...: :....|:.|.|..|||.....:..::.|.|.:.|..|.|:.|.:|..|:.....|:|.|
Mouse   931 LCEALKNPKSKLKSLWLCGCSITPLNCQDFSETLRSNKSLNTLDLSQNVLGTDAIKTFCEALKLQ 995

  Fly   334 -CKLEKLTLYGNHFDSRTAMIVRRLLDAEVVLHSELDIS 371
             |.|:.|.|   .||.....| :.|:....|.|.:|.||
Mouse   996 ICPLQMLRL---KFDEAKPSI-QNLIQEMKVSHPQLRIS 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_610445.1	RNA1	<133..345	CDD:444072	58/216 (27%)
		leucine-rich repeat	202..220	CDD:275380	5/20 (25%)
		leucine-rich repeat	223..251	CDD:275380	6/27 (22%)
		leucine-rich repeat	252..279	CDD:275380	8/27 (30%)
		leucine-rich repeat	280..307	CDD:275380	8/26 (31%)
		leucine-rich repeat	308..335	CDD:275380	9/27 (33%)
		leucine-rich repeat	336..357	CDD:275380	6/20 (30%)
Nlrp2	NP_808358.2	Pyrin_NALPs	11..94	CDD:260032
		P-loop containing Nucleoside Triphosphate Hydrolases	182..345	CDD:476819
		NLRC4_HD2	493..605	CDD:465499
		leucine-rich repeat	743..766	CDD:275380
		PPP1R42	<769..1008	CDD:455733	69/274 (25%)
		leucine-rich repeat	771..798	CDD:275380	3/6 (50%)
		leucine-rich repeat	799..827	CDD:275380	6/46 (13%)
		leucine-rich repeat	828..855	CDD:275380	9/26 (35%)
		leucine-rich repeat	856..884	CDD:275380	10/53 (19%)
		leucine-rich repeat	885..912	CDD:275380	8/35 (23%)
		leucine-rich repeat	913..941	CDD:275380	8/27 (30%)
		leucine-rich repeat	942..969	CDD:275380	8/26 (31%)
		leucine-rich repeat	970..989	CDD:275380	6/18 (33%)