Protein Alignment CG8197 and NLRC3

DIOPT Version :10

• Sequence 1: NP_610445.1
• Gene: CG8197 / 35912
• FlyBaseID: FBgn0033369
• Length: 387
• Species: Drosophila melanogaster
• Sequence 2: NP_849172.2
• Gene: NLRC3 / 197358
• HGNCID: 29889
• Length: 1065
• Species: Homo sapiens
• Alignment Length: 416
• Identity: 91/416 - (21%)
• Similarity: 149/416 - (35%)
• Gaps: 112/416 - (26%)

  Fly    30 LLYCWQREYDKRPYRQFQFKRLTFEERIGRRYHCIRDLRIIVNYLLRRPQLSVQISSLV---VSN 91
            ||||.:...|..     ||:....|               ::..:|......:|..||.   :||
Human   636 LLYCRKLRLDTN-----QFQDPVME---------------LLGSVLSGKDCRIQKISLAENQISN 680

  Fly    92 WDAGLLKDFVRSLL---PVWYIELRLMRFPREFFVMLRLNAAKMN--VSQLSLEGTPLTDEDVRI 151
            ..|   |...||||   .:..::||......:....| .:|.|:|  ::.|||:|..:.|:..|.
Human   681 KGA---KALARSLLVNRSLTSLDLRGNSIGPQGAKAL-ADALKINRTLTSLSLQGNTVRDDGARS 741

  Fly   152 LREFLLVSKTLRRLNVSSCSLTQFNFALIADGVYKSPGVRRL--SANRL---------------L 199
            :.|.|..::||..|::...|:.......:||.:.::..::.|  |:|.:               .
Human   742 MAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQ 806

  Fly   200 GM-SLSLDTEKIS-----SVLSSLLMQNTLWALSLEHCELTAQDMIPIAEHLARTNSKFRRLRIA 258
            |: ||.|.:..||     :::.:|....||.:|||....::.:....|| |....||..:.|.:.
Human   807 GLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIA-HALCANSTLKNLDLT 870

  Fly   259 C--------------------------------------------------------NKIGPDGA 267
            .                                                        |.||.|||
Human   871 ANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGA 935

  Fly   268 FFLLRGMSMGGNLELLDLSYCSIGTHGGEWVAKYLASCRRLQVLHLNYNDMGPTAVNLILLAMKK 332
            ..:.|.:.:...|..|.|...|||..|.:.:.:.||..|.|::|.|..|.:|......:..|:|.
Human   936 CAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKV 1000

  Fly   333 QCKLEKLTLYGNHFDSRTAMIVRRLL 358
            ...|.:|.|..|......|:.:...|
Human  1001 NSSLRRLNLQENSLGMDGAICIATAL 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_610445.1	RNA1	<133..345	CDD:444072	63/292 (22%)
		leucine-rich repeat	202..220	CDD:275380	6/22 (27%)
		leucine-rich repeat	223..251	CDD:275380	8/27 (30%)
		leucine-rich repeat	252..279	CDD:275380	8/82 (10%)
		leucine-rich repeat	280..307	CDD:275380	9/26 (35%)
		leucine-rich repeat	308..335	CDD:275380	7/26 (27%)
		leucine-rich repeat	336..357	CDD:275380	5/20 (25%)
NLRC3	NP_849172.2	LRR 12	917..940		6/22 (27%)
		leucine-rich repeat	920..947	CDD:275380	7/26 (27%)
		LRR 13	945..968		7/22 (32%)
		leucine-rich repeat	948..975	CDD:275380	9/26 (35%)
		LRR 14	973..996		6/22 (27%)
		leucine-rich repeat	976..1003	CDD:275380	7/26 (27%)
		LRR 15	1001..1029		6/26 (23%)
		leucine-rich repeat	1004..1031	CDD:275380	6/23 (26%)
		LRR 16	1031..1052
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62
		NACHT	139..305	CDD:428606
		NOD2_WH	395..453	CDD:465501
		NLRC4_HD2	455..582	CDD:465499
		TRAF6-binding. /evidence=ECO:0000269|PubMed:22863753	457..460
		RNA1	573..902	CDD:444072	61/290 (21%)
		LRR 1	617..639		2/2 (100%)
		leucine-rich repeat	636..667	CDD:275380	9/50 (18%)
		LRR 2	641..663		5/41 (12%)
		LRR 3	665..688		7/25 (28%)
		leucine-rich repeat	668..695	CDD:275380	11/29 (38%)
		LRR 4	693..716		3/23 (13%)
		leucine-rich repeat	696..723	CDD:275380	6/27 (22%)
		LRR 5	721..744		7/22 (32%)
		leucine-rich repeat	724..751	CDD:275380	8/26 (31%)
		LRR 6	749..772		4/22 (18%)
		leucine-rich repeat	752..779	CDD:275380	5/26 (19%)
		PPP1R42	766..1053	CDD:455733	53/262 (20%)
		LRR 7	777..800		3/22 (14%)
		leucine-rich repeat	780..807	CDD:275380	3/26 (12%)
		LRR 8	805..828		6/22 (27%)
		leucine-rich repeat	808..833	CDD:275380	6/24 (25%)
		LRR 9	833..856		7/23 (30%)
		leucine-rich repeat	836..863	CDD:275380	8/27 (30%)
		LRR 10	861..884		3/22 (14%)
		leucine-rich repeat	864..891	CDD:275380	1/26 (4%)
		LRR 11	889..912		0/22 (0%)
		leucine-rich repeat	892..919	CDD:275380	0/26 (0%)