DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and si:dkey-118k5.3

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	XP_005157726.1	Gene:	si:dkey-118k5.3 / 101882478	ZFINID:	ZDB-GENE-121214-294	Length:	887	Species:	Danio rerio

Alignment Length:	376	Identity:	83/376 - (22%)
Similarity:	136/376 - (36%)	Gaps:	114/376 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RPYRQFQFKRLTFEERIGRRY---HCIRDLRIIVNYLLRRPQLSVQISSLVVSNWDAGLLKDFVR 102
            ||.|.| .:|:....|.|.::   |.....|.:...|:.|.:|               :|..|
Zfish   574 RPRRLF-CRRIKKALRCGEQHQSGHMDLFCRFVCGLLVPRTRL---------------ILNGF-- 620

  Fly   103 SLLPVWYIELRLMRFPREFFVMLRLNAAKMNVSQLSLEGTP-LTDEDVRILREFLLVSKTL---R 163
                          ||         :..||::  |..|.:| ||...:..|....|.|.||   |
Zfish   621 --------------FP---------DGPKMHL--LRCELSPDLTPPFLLHLLHSQLQSSTLGPER 660

  Fly   164 RLNVSSCSLTQFNFALIADGVYKS--PGV-RRL----------------SANR-------LLGMS 202
            ::||..|             :|::  ||: :||                |.||       ||.:|
Zfish   661 QVNVCHC-------------LYEAQDPGLSQRLQGWMKVLSQQASDQSGSVNRDWSELAFLLQLS 712

  Fly   203 ----------LSLDTEKISSVLSSLLMQNTLWALSLEHCELTAQDMIPIAEHLARTNSKFRRLRI 257
                      ..||.:.:|.:|..|.:.:|   |||....|.::....::..|...:....||.:
Zfish   713 PDLQVLHLDAQGLDADGLSRLLPVLPLFST---LSLGQNPLGSEGAAVLSLVLRSPDCCIERLWV 774

  Fly   258 ACNKIGPDGAFFLLRGMSMGGNLELLDLSYCSIGTHGGEWVAKYLASCRRLQVLHLNYNDMGPTA 322
            ....:|.:|...|...:.....:..|.::...||..|..::|..|.:.|.|..:.|..|.:....
Zfish   775 VATGLGCEGLRILAEALKENRTVTDLRMAINKIGDAGAGYLADLLRTNRTLTDIRLRDNLVTDKG 839

  Fly   323 VNLILLAMKKQCKLEKLTLYGNHFDSRTAMIVRRL---------LDAEVVL 364
            ..:::.|:|:...|:.|.|:.|.|   |...||:|         ||.:|.:
Zfish   840 AEILMSALKENTTLKYLWLFDNKF---TKDGVRKLKEFAKTRPNLDIKVCI 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	8/27 (30%)
		LRR_RI	137..374	CDD:238064	65/277 (23%)
		leucine-rich repeat	162..189	CDD:275381	6/31 (19%)
		leucine-rich repeat	202..220	CDD:275380	6/27 (22%)
		leucine-rich repeat	223..251	CDD:275380	5/27 (19%)
		leucine-rich repeat	252..279	CDD:275380	5/26 (19%)
		leucine-rich repeat	280..307	CDD:275380	6/26 (23%)
		leucine-rich repeat	308..335	CDD:275380	5/26 (19%)
		leucine-rich repeat	336..357	CDD:275380	8/20 (40%)
si:dkey-118k5.3	XP_005157726.1	CARD	10..80	CDD:260018
		P-loop_NTPase	187..345	CDD:304359
		LRR_RI	<709..881	CDD:238064	39/177 (22%)
		leucine-rich repeat	733..763	CDD:275380	7/32 (22%)
		leucine-rich repeat	769..796	CDD:275380	5/26 (19%)
		leucine-rich repeat	797..820	CDD:275380	5/22 (23%)
		leucine-rich repeat	825..852	CDD:275380	5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900