DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8197 and si:dkey-23k10.3

DIOPT Version :9

Sequence 1:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	XP_009290117.1	Gene:	si:dkey-23k10.3 / 100150225	ZFINID:	ZDB-GENE-131126-11	Length:	692	Species:	Danio rerio

Alignment Length:	445	Identity:	98/445 - (22%)
Similarity:	154/445 - (34%)	Gaps:	140/445 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 IIVNYLLRR-----PQLSVQISSLVVSNWDAGLLKDFVRSLLPVWYIE-LRLMR--FPREFFVML 125
            :::|..||.     .:|.:..:||...:  ..||...:.|  |.|.:: |:|:.  |..|....|
Zfish   192 VVLNKALRSNPSHLKELDLSENSLCYLH--TMLLSSVLES--PYWELKTLKLVNCSFTEEGGAAL 252

  Fly   126 RLNAAKMNVSQLSLEGTPLTDEDVRILREFLLVSK------TLRRLNVSSCSLTQFNFALIADGV 184
             ::|.:.|.|.  |....|:..::..|...:|.|.      .|..|.::.|.:|...||.:..|:
Zfish   253 -MSALRSNPSH--LRELDLSKNNIGYLTMMVLSSAMEIPYWELEILRLNDCGITDDGFAALGAGL 314

  Fly   185 YKSPGVRR---LSANRL-------LGMSL-----SLDTEKISS---------VLSSLLMQN---- 221
            ..:|...|   ||.|:|       |.::|     .|:|.::.|         ||.|.|..|
Zfish   315 RSNPSYLRELDLSKNKLGEFGVHMLSIALEMPYCQLETLRLVSCDITGNGWIVLVSALRSNPSHL 379

  Fly   222 ---------------------------TLWALSLEHCELTAQDMIPIAEHLARTNSKFRRLRIAC 259
                                       .|..|.|.:|.|..::.:.:|..|....||.|.|.::.
Zfish   380 RNLDLSGNNLECFEIKLLSEVLESPYCKLETLKLRNCNLKDEECVSLASALRLKISKLRELDLSE 444

  Fly   260 NKIGPDG--AFFL-------------------------------------LRGMSMGGN------ 279
            ||:|..|  |||.                                     |:.:.:.||
Zfish   445 NKLGDSGVKAFFAELEGHLSKFDALRFVNCGLTDEGCGVLASVLSSNPSHLKELDLSGNKVEDSG 509

  Fly   280 --------------LELLDLSYCSIGTHGGEWVAKYLAS-CRRLQVLHLNYNDMGPTAVNLILLA 329
                          ||.|.|..|.:...|...:|..|.| ...|:||.|:.|.:..:.|.||...
Zfish   510 VKMLSDGLEDYCCRLETLKLVGCGLTDEGCASLASALTSNSSHLRVLDLSKNKLSDSGVRLISTG 574

  Fly   330 MKK-QCKLEKLTLYGNHFDSRTAMIVRRLLDAEVVLHSELDISYTYDEALQDYRV 383
            ::. .||:|.|.|.....:......:...|........|||:|   :..|.|:.|
Zfish   575 LENPHCKVEILWLVDCDVNDEGCAALASALTFNFSNLRELDLS---ENNLGDFGV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	6/32 (19%)
		LRR_RI	137..374	CDD:238064	76/358 (21%)
		leucine-rich repeat	162..189	CDD:275381	7/26 (27%)
		leucine-rich repeat	202..220	CDD:275380	8/31 (26%)
		leucine-rich repeat	223..251	CDD:275380	7/27 (26%)
		leucine-rich repeat	252..279	CDD:275380	10/65 (15%)
		leucine-rich repeat	280..307	CDD:275380	9/27 (33%)
		leucine-rich repeat	308..335	CDD:275380	8/27 (30%)
		leucine-rich repeat	336..357	CDD:275380	3/20 (15%)
si:dkey-23k10.3	XP_009290117.1	LRR_RI	59..360	CDD:238064	42/174 (24%)
		leucine-rich repeat	60..88	CDD:275380
		leucine-rich repeat	89..117	CDD:275380
		leucine-rich repeat	118..146	CDD:275380
		leucine-rich repeat	147..175	CDD:275380
		leucine-rich repeat	176..203	CDD:275380	3/10 (30%)
		leucine-rich repeat	205..233	CDD:275380	7/31 (23%)
		leucine-rich repeat	234..262	CDD:275380	7/28 (25%)
		leucine-rich repeat	263..291	CDD:275380	5/27 (19%)
		LRR_RI	291..591	CDD:238064	66/299 (22%)
		leucine-rich repeat	292..320	CDD:275380	8/27 (30%)
		leucine-rich repeat	350..378	CDD:275380	8/27 (30%)
		leucine-rich repeat	408..436	CDD:275380	7/27 (26%)
		leucine-rich repeat	437..465	CDD:275380	9/27 (33%)
		leucine-rich repeat	469..494	CDD:275381	0/24 (0%)
		leucine-rich repeat	495..523	CDD:275381	3/27 (11%)
		leucine-rich repeat	524..552	CDD:275381	9/27 (33%)
		leucine-rich repeat	553..581	CDD:275381	8/27 (30%)
		leucine-rich repeat	582..610	CDD:275381	4/27 (15%)
		LRR_RI	609..635	CDD:197686	7/21 (33%)
		leucine-rich repeat	611..639	CDD:275381	7/19 (37%)
		leucine-rich repeat	640..668	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900