DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PPO2 and Lsp1gamma

DIOPT Version :9

Sequence 1:	NP_610443.1	Gene:	PPO2 / 35910	FlyBaseID:	FBgn0033367	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_523868.1	Gene:	Lsp1gamma / 38015	FlyBaseID:	FBgn0002564	Length:	772	Species:	Drosophila melanogaster

Alignment Length:	831	Identity:	191/831 - (22%)
Similarity:	306/831 - (36%)	Gaps:	247/831 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKNLLLL--------FDHPTEPV------FMDKGKRVTVFDVPDSFLTDRYRPISNEVQSRVGDK 54
            |..|::|        |..||:.|      |::|.|  .:|::....    ..|:..|...::|.|
  Fly     2 KLTLVILALVACVTAFSVPTQKVKIADKNFLEKQK--FLFEIVHRI----DEPLMFEEWIKMGQK 60

  Fly    55 V---EQRVPVREISIPDLRIPMSLG----RDEQFSLFLPKHRRIAGRLIDIFMNMRSVDDLQSVA 112
            :   :.:....:..:..|.....||    :.|.|...:..|.:.|..|.:.|...:..:......
  Fly    61 LITDKAQYETFDFYMEKLWESYKLGALLPKGEFFGALVKTHHKQAYGLFNFFYYAKDWETFVRNV 125

  Fly   113 VYARDRVNPVLFNYALSVALLHRPDTQGLDLPSFSQTFPDRFIDS-----------QVIRK---- 162
            .:||..||..:|.|||::|::|:|:.:||.||...:.||..|.:|           :|..|
  Fly   126 AWARIHVNEGMFVYALTLAVIHKPEFEGLILPQIYEIFPQYFFNSKFVYAAEKFDYEVFSKLTMY 190

  Fly   163 ------------------------------------------------MRE--ESFVVQP----- 172
                                                            :||  ..||..|
  Fly   191 EKEYKDILYKDYSEFTGNFYFYTKDWKTWQWYKMMGLDQEWYVEDKYFLRENLSQFVNDPKYVDV 255

  Fly   173 --GSR---MPITIPRDYTASDLD---PEHRLWYFREDLGINLHHWHWHLVYPFEASDRSI-VAKD 228
              |.:   ||:    ||| .|:|   .|.::.||.||||.|.:.::.::.|.|..:.:.. :.||
  Fly   256 VKGLKKFYMPV----DYT-RDIDFFNDETKMTYFTEDLGWNAYWYYLNMDYAFFLNGKQFGLDKD 315

  Fly   229 RRGELFYYMHQQVIARYNAERFSNNLARVLPFNNLRDPIAEGYFPKM---------------DSL 278
            ||||.:.|..||::|||..||.:|....:..|...:. |..||.|::               |..
  Fly   316 RRGEYWIYNVQQILARYYQERLANGFGEIPEFFWYKQ-IEYGYDPQLIYYNGIGYSYRKNYYDFY 379

  Fly   279 VASRAWPPRFESTRLSDLNRESDQLNVEIGDLERWRDRIYEAIHQGFVMDERGNRVPLDEATGID 343
            ...     :||.                ...::.:..|:|:.:..||.....|....|.:...|.
  Fly   380 TYG-----KFEM----------------YSQIQNFFSRVYKVLETGFYKTADGQVFDLHKPEAIK 423

  Fly   344 TLGNMIESSILSPNRVLYGDLHNNGHTFISY--------AH----DPTSKHLESF-GVMGDVSTA 395
            .:||.               |..|..||..|        ||    |.....:|.| .|..:..|.
  Fly   424 IVGNY---------------LQGNADTFDKYFFNYYYLLAHMYFADVDYNDMEVFPNVFLNFETM 473

  Fly   396 MRDPVFYKWHSYIDRIFQEHKSRLPAYTENQLNYPGVSIAGIQVDTNGGRPNNLTTFWQQSDVDM 460
            :|||.||.::.....:|...|..|..||:..|.|.|::|..:.|       :.|.|::...|.|:
  Fly   474 LRDPFFYTFYKKFTDVFYTFKYYLKPYTQKDLFYEGITIKDVSV-------SKLVTYYDIVDFDV 531

  Fly   461 SRGFD---------FLPRGNVFARFTHLQHLPFTYTISLNNDSGAQRFGYVRIFMAPKNDERGQP 516
            :...:         ::....:.||...|.|.||.:..::::|. .|: |.||:|:.||.||.|:.
  Fly   532 TNLLNDKMTFVDGQYIWDKALLARQARLNHKPFNFEFTIDSDK-VQK-GVVRVFLGPKFDEYGRV 594

  Fly   517 MLMRDQRSMMIELDKFVTSLNPGPNTIRRRSTESSVTIPFERTFRN----------------LDA 565
            :.:...|...:::|.||.....|.|||:|.|.|.|.|.....|:..                ||.
  Fly   595 IPLDYNRKNFVQIDSFVYPFIAGTNTIKRSSKEFSWTAEDRITYTELYKYVMLASEGKYDFPLDI 659

  Fly   566 NRPAAGTPEELEFNFCGCGWPNHMLVPKGLPEGLQCVLFIMVS----NYEN----DRIDQQLVGR 622
            :.|..             .:|:.:::|||..:|:....:..||    .||.    |......||
  Fly   660 SEPHN-------------AFPDRLVLPKGWEQGMPMQFYFFVSPFAETYEQFSNFDYTYSSGVG- 710

  Fly   623 CSDAASYCGVRDRLYPDRQSMGFPFDRLPRSGVDRLVNFLTPNMSIVDVNI 673
                   .|.|   :.|.:..|:||||    .:|. .:|..||....||.:
  Fly   711 -------SGTR---FVDTKPFGYPFDR----QIDE-SDFFVPNGFFKDVKV 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PPO2	NP_610443.1	Hemocyanin_N	19..140	CDD:281684	28/127 (22%)
		Hemocyanin_M	150..412	CDD:278784	78/368 (21%)
		Hemocyanin_C	421..675	CDD:281685	71/286 (25%)
Lsp1gamma	NP_523868.1	Hemocyanin_N	31..153	CDD:397678	28/127 (22%)
		Hemocyanin_M	159..490	CDD:395296	78/372 (21%)
		Hemocyanin_C	499..747	CDD:397679	71/286 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470661
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11511
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940