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Protein Alignment Ance-4 and ACE2

DIOPT Version :9

Sequence 1:	NP_610442.2	Gene:	Ance-4 / 35909	FlyBaseID:	FBgn0033366	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001358344.1	Gene:	ACE2 / 59272	HGNCID:	13557	Length:	805	Species:	Homo sapiens

Alignment Length:	641	Identity:	163/641 - (25%)
Similarity:	282/641 - (43%)	Gaps:	83/641 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLVLIAGIGCATAA-ANIDLEAKTFV----NQSSDRYYRFYNEIAAETYSANNEEDFDALFSKL 64
            |||.|:|    .||| :.|:.:||||:    :::.|.:|:  :.:|:..|:.|..|:      .:
Human     7 LLLSLVA----VTAAQSTIEEQAKTFLDKFNHEAEDLFYQ--SSLASWNYNTNITEE------NV 59

  Fly    65 NNVKRIAEELVSISRQAAT----YDLDRIRSPQTKMALQELRTAGDLFVLGDDYFSSVQMNLAAL 125
            .|:....::..:..::.:|    |.|..|::...|:.||.|:..|. .||.:|....:...|..:
Human    60 QNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGS-SVLSEDKSKRLNTILNTM 123

  Fly   126 QTL-STDKDIEPYLGGANMPNEDDSP---LAYFPDIQKIVQSSKDADELKYYWEAWRD------- 179
            .|: ||.|...|           |:|   |...|.:.:|:.:|.|.:|..:.||:||.
Human   124 STIYSTGKVCNP-----------DNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLR 177

  Fly   180 ---------KNQLWASLNFYTIVQSYQRAAKILEVPVHKL-WYRYDSQEMLQQMEQAMTELRPAY 234
                     ||:: |..|.|.....|.|.    :..|:.: .|.|...::::.:|....|::|.|
Human   178 PLYEEYVVLKNEM-ARANHYEDYGDYWRG----DYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLY 237

  Fly   235 QQLHAFVRQELHKKYGSDVVNLNGPIPDHLFQQVLEQAWASGSILEDYYPRAQLPEFDEYVSHL- 298
            :.|||:||.:|...|.|.:..: |.:|.||...:..:.|.  ::.....|..|.|..|...:.:
Human   238 EHLHAYVRAKLMNAYPSYISPI-GCLPAHLLGDMWGRFWT--NLYSLTVPFGQKPNIDVTDAMVD 299

  Fly   299 ---TAKTMVNESENFYTSLGFEPLSAEFHKNQLKEPNQDSPNDDCRPSIFDLTPHVY-LMYCEKV 359
               .|:.:..|:|.|:.|:|...::..|.:|.:.....:.....|.|:.:||....: ::.|.||
Human   300 QAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKV 364

  Fly   360 SFRKLMQYHSHMARVYYAQQKSHLPSYYFKAYNLEF--AVGEAVVLSASSPAHLTGRRLAKEVLS 422
            :....:..|..|..:.|....:..|.......|..|  ||||.:.|||::|.||....|......
Human   365 TMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQ 429

  Fly   423 E--TALMSRLFRMAIHTILSIPLYYVHTKVMHDLLNDTVDMDTVNKHYWRLMEQHAGIEAPSDRS 485
            |  ...::.|.:.|:..:.::|..|:..|....:....:..|...|.:|.:..:..|:..|....
Human   430 EDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHD 494

  Fly   486 EGAIDFPYKFYVNIDQSFQTQKFISEVLGYQFYREFCKKSYNRGPLHNCDFYGSLAVGNDLKAMM 550
            |...|....|:|:.|.|| .:.:...:..:||....|:.:.:.||||.||...|...|..|..|:
Human   495 ETYCDPASLFHVSNDYSF-IRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNML 558

  Fly   551 SLGSTKPW----KQVVGKILPNNTGLSSLALLEYYQPVLDWLNKYNKDANSKIGWT 602
            .||.::||    :.|||.     ..::...||.|::|:..||...||  ||.:||:
Human   559 RLGKSEPWTLALENVVGA-----KNMNVRPLLNYFEPLFTWLKDQNK--NSFVGWS 607

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.