DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-4 and ace

DIOPT Version :9

Sequence 1:	NP_610442.2	Gene:	Ance-4 / 35909	FlyBaseID:	FBgn0033366	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	XP_694336.5	Gene:	ace / 565980	ZFINID:	ZDB-GENE-030131-1826	Length:	1324	Species:	Danio rerio

Alignment Length:	599	Identity:	165/599 - (27%)
Similarity:	285/599 - (47%)	Gaps:	43/599 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DLEAKTFVNQSSDRYYRFYNEIAAETYSANNEEDF----DALFSKLNNVKRIAEELVSISR---- 79
            :::||.|:::        ||..|.|.::|..|..:    |...:..:|:.:...|:.:.::
Zfish   674 EMQAKQFLDE--------YNSTAEEVWNAYTESSWTYNTDITEAHKDNMLQKNLEMANHTKIYGL 730

  Fly    80 QAATYDLDRIRSPQTKMALQELRTAGDLFVLGDDYFSSVQMN--LAALQTLSTDKDIEPYLGGAN 142
            :|..||....:....|..|.:|.......:..:|.   |:.|  ||:::||         ...|.
Zfish   731 EARKYDTSDFQDESVKRILSKLSDLERAALSAEDL---VEYNNLLASMETL---------YSVAT 783

  Fly   143 MPNEDDSPLAYFPDIQKIVQSSKDADELKYYWEAWRDKNQLWASLNFYTIVQSYQRAAKILEVPV 207
            :..:..:.|...||:.||:..|:|.|||.:.|:.||:.:......::...|:....|||......
Zfish   784 VCKDKSNCLPLDPDLNKIMAESRDYDELLFAWQGWRNASGREIRDSYKRYVELANSAAKSNGHTD 848

  Fly   208 HKLWYR--YDSQEMLQQMEQAMTELRPAYQQLHAFVRQELHKKYGSDVVNLNGPIPDHLFQQVLE 270
            :..::|  |::....|.:|....:|.|.|..:||:||:.|:||||.:.:||.||||.||...:..
Zfish   849 NGAFWRSLYETPTFEQDLEALWKDLEPLYLSVHAYVRRALYKKYGPERINLKGPIPAHLLGNMWA 913

  Fly   271 QAWASGSILEDYYPRA-QLPEFDEYVSH-LTAKTMVNESENFYTSLGFEPLSAEF-HKNQLKEPN 332
            |.|:....|.:.||.| |:......::. .|.|.|..||:.|:||||..|:..|| :|:.|::|.
Zfish   914 QTWSGIMDLVNPYPDATQVDATPAMIAQGWTPKRMFEESDRFFTSLGLLPMPPEFWNKSMLEKPT 978

  Fly   333 QDSPNDDCRPSIFDL--TPHVYLMYCEKVSFRKLMQYHSHMARVYYAQQKSHLPSYYFKAYNLEF 395
             |.....|..|.:|.  .....:..|..|:...|:..|..|..|.|..|....|..:....|..|
Zfish   979 -DGREVVCHASAWDFYNRKDFRIKQCTVVTMDDLITVHHEMGHVQYFLQYKDQPISFRDGANPGF 1042

  Fly   396 --AVGEAVVLSASSPAHLTGRRLAKEVLSET-ALMSRLFRMAIHTILSIPLYYVHTKVMHDLLND 457
              |:|:.:.||.::|.||....|..:|.... :.::.|..:|:..|..:|..|:..:....:.:.
Zfish  1043 HEAIGDVLALSVATPKHLQSIGLLDKVEDNAESTINFLMSIALDKIAFLPFGYLMDQWRWKVFDG 1107

  Fly   458 TVDMDTVNKHYWRLMEQHAGIEAPSDRSEGAIDFPYKFYVNIDQSFQTQKFISEVLGYQFYREFC 522
            .:.....||.:|.|..::.|:..|..|:|...|...||::..:..: .:.|:|.|:.:||::..|
Zfish  1108 RISSSEYNKEWWNLRMKYQGLCPPVPRTEKDFDPGAKFHIPANVPY-IRYFVSFVIQFQFHKGLC 1171

  Fly   523 KKSYNRGPLHNCDFYGSLAVGNDLKAMMSLGSTKPWKQVVGKILPNNTGLSSLALLEYYQPVLDW 587
            ..:.::|||||||.|.|...|..|..:|.:|.:|||.:.: ||:.....:|...|:||::|:::|
Zfish  1172 DAAGHKGPLHNCDIYQSKEAGKLLSDVMKMGFSKPWPEAM-KIITGQPKMSVQPLMEYFKPLIEW 1235

  Fly   588 LNKYNKDANSKIGW 601
            |.|.|:.....:||
Zfish  1236 LEKENEKNGDVLGW 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-4	NP_610442.2	GluZincin	25..601	CDD:301352	163/595 (27%)
ace	XP_694336.5	Peptidase_M2	69..651	CDD:279709
ace	XP_694336.5	Peptidase_M2	671..1249	CDD:279709	163/597 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850