Protein Alignment Ance-4 and Ace3

DIOPT Version :10

• Sequence 1: NP_610442.2
• Gene: Ance-4 / 35909
• FlyBaseID: FBgn0033366
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_001245166.1
• Gene: Ace3 / 498012
• RGDID: 1561299
• Length: 737
• Species: Rattus norvegicus
• Alignment Length: 618
• Identity: 161/618 - (26%)
• Similarity: 276/618 - (44%)
• Gaps: 72/618 - (11%)

  Fly    27 KTFVNQSSDRYY---------RFYNEIAAETYSANNEEDFDALFSKLNNVKRIAEE--------- 73
            ||....|.|.:|         :||.:.|....:    |..:|.::.:.|:.:..:|
  Rat    22 KTVGEPSLDEFYSEAQAKMFLQFYEQTARVVLN----ELMEATWNYVTNITKQNQENMLQKEVER 82

  Fly    74 ---LVSISRQAATYDLDRIRSPQTKMALQELRTAGDLFVLGDDYFSSVQMNLAALQTLSTDKDIE 135
               ::....:|..:.:|..:....|..|.:||.. |...|..:.|......|..::|.
  Rat    83 SQFMLYFGTRARMFRIDHFQDLDVKRRLSKLRNI-DKSALPVEDFQEFNRLLTYMKTA------- 139

  Fly   136 PYLGGANMPNEDDSPLAYFPDIQKIVQSSKDADELKYYWEAWRDK--NQLWASLNFYTIVQSYQR 198
              .|.|.:..::...:...||:::|:.:|:|..||.:.|:.|||.  .||......|..:.:
  Rat   140 --YGRAEVCLDEGPCMPLEPDLEEIMATSRDQKELLWAWQGWRDAIGRQLRPVFEDYVHLSN--- 199

  Fly   199 AAKILEVPVHK----LW-YRYDSQEMLQQMEQAMTELRPAYQQLHAFVRQELHKKYGSDVVNLNG 258
              |..:...:|    || .:|:|..:.:.:||...||:|.|..|||:||:.|::.||.::::|.|
  Rat   200 --KAAQYNGYKDMGALWRSKYESDTLEEDLEQLYKELQPLYLNLHAYVRRSLYRYYGPELIDLRG 262

  Fly   259 PIPDHLFQQVLEQAWASGSILEDYYPRAQLPEFD----EYVSHLTAKTMVNESENFYTSLGFEPL 319
            |||.||...:..|:|  .:||:...|....|..|    ....|...:.|..|:..|:||:|..|.
  Rat   263 PIPAHLLGNMWAQSW--NNILDLVLPYPNKPPEDITKIMKNQHWRPEKMFEEANLFFTSMGMLPA 325

  Fly   320 SAEFHKNQLKEPNQDSPNDDCRPSIFDLTPHVY------LMYCEKVSFRKLMQYHSHMARVYYAQ 378
            ...|....:.|...|....:|..|.::.    |      :..|.:|:...|:.....|..:.|..
  Rat   326 PPAFWMKSMMEKPVDGREVECHTSSWNF----YRLNDFRVKKCTEVTIGDLLSIFHQMGHIQYYL 386

  Fly   379 QKSHLPSYYFKAYN--LEFAVGEAVVLSASSPAHLTGRRLAKEVLSET-ALMSRLFRMAIHTILS 440
            |..:|...|.:..:  .|.|||..:.|||.|..:|..|.|..:...:: ..::.|..:|:..|..
  Rat   387 QCQNLSIIYQEGASPAFEEAVGSTITLSAFSHKYLLTRGLLSQQHQDSEEEVNFLLSIALEKIAF 451

  Fly   441 IPLYYVHTKVMHDLLNDTVDMDTVNKHYWRLMEQHAGIEAPSDRSEGAIDFPYKFYVNIDQSFQT 505
            ||..|:.......:.:.|:..:..|:.:|.|..::.|:..|..|||...|...||::..:..: .
  Rat   452 IPFGYMIDLFRWKVFDGTIQKNAYNQEWWSLRLKYQGLCPPVPRSEDDFDPGAKFHIPANMPY-I 515

  Fly   506 QKFISEVLGYQFYREFCKKSYNRGPLHNCDFYGSLAVGNDLKAMMSLGSTKPWKQVVGKIL--PN 568
            :.|:|.||.:|.:...|:.|.:.||||.||.|.|...|..|...:.:||::||::|:.:|.  ||
  Rat   516 RYFLSLVLQFQLHEVLCRASGHVGPLHRCDIYNSKVAGKILGDFLKVGSSRPWQEVLKEITGKPN 580

  Fly   569 NTGLSSLALLEYYQPVLDWLNKYNKDANSKIGW 601
               :|:.|||.|::|:|:||...|......:||
  Rat   581 ---ISTKALLTYFKPLLNWLVTENVKQGDILGW 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ance-4	NP_610442.2	M2_ACE	29..592	CDD:341055	156/605 (26%)
Ace3	NP_001245166.1	Peptidase_M2	33..610	CDD:460196	155/605 (26%)