DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-4 and Ance-3

DIOPT Version :9

Sequence 1:	NP_610442.2	Gene:	Ance-4 / 35909	FlyBaseID:	FBgn0033366	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001033904.1	Gene:	Ance-3 / 34808	FlyBaseID:	FBgn0032536	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	633	Identity:	180/633 - (28%)
Similarity:	287/633 - (45%)	Gaps:	86/633 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLLLVLIAGIGCATAAANIDLE--AKTFVN--------QSSDRYYRFYNEIAAETYSANNEEDF 57
            |.:|||.....|.....||:..:  .:|.||        .:..||..|....|.::...|.:..|
  Fly   213 LRILLVESDQKGSLECTANVAAQWNFETNVNDFTQTEALNAQQRYVEFQRITAEQSKRINKDLIF 277

  Fly    58 DALFSKLNNVKRIAEELV---SISRQAATYD-LDRIRSPQTKMALQELRTAGDLFVLGDDYFSSV 118
            |         :|:..:|:   .:...|...| |||......:|          ||:     ::|.
  Fly   278 D---------RRLYRQLMLQSEVGPNALPLDVLDRYNRLLNEM----------LFL-----YNSA 318

  Fly   119 QMNLAALQTLSTDKDIEPYLGGANMPNEDDSPLAYFPDIQKIVQSSKDADELKYYWEAWRDKNQL 183
            :  :.|.|        :|:          ...|.|.|.::.|:..|:|.|||::.|..:..|...
  Fly   319 E--ICAYQ--------QPF----------QCDLHYIPQLKDIMAKSRDWDELQHTWVEYHRKAGR 363

  Fly   184 WASLNFYTIVQSYQRAAKILEVP-VHKLWY-RYDSQEMLQQMEQAMTELRPAYQQLHAFVRQELH 246
            ....::..::...|..|.:..|. ..:.|| .|:|....|.|:....::||.|:.|||:||::|.
  Fly   364 GMRDSYEQLIDVMQEVAYVNNVTNGGEYWYLAYESGNFRQDMDIVWEQIRPLYEGLHAYVRRKLR 428

  Fly   247 KKYGSDVVNLNGPIPDHLFQQVLEQAWASGSILEDYYPRAQL----PEFDEYVSHLTAKTMVNES 307
            ..||.|.:|...|||.|:...:..|:|::...:...||..:|    |...|  ...|.:.|...:
  Fly   429 DYYGPDRINRIAPIPSHILGNMYGQSWSNVLDILIPYPGRKLIDVTPRMVE--QGYTPQLMFQLA 491

  Fly   308 ENFYTSLGFEPLSAEFHKNQLKEPNQDSPNDD---CRPSIFDL-TPHVY-LMYCEKVSFRKLMQY 367
            |.|:||:....:..||::|.:.|    .|.|.   |.||.:|. ..|.: :..|..::.|.|:..
  Fly   492 EEFFTSINMSAVGPEFYRNSIFE----QPLDRRVLCEPSAWDFCNRHDFRVKICTDINQRSLISV 552

  Fly   368 HSHMARVYYAQQKSHLPSYYFKAYNLEF--AVGEAVVLSASSPAHLTGRRLAKEVLSETAL-MSR 429
            |..||.:.|..|..|||..:....|..|  |||:|:.||.|:|.||....|.:..|.|::. ::.
  Fly   553 HHEMAHIQYFLQYRHLPKIFRNGANPAFHQAVGDAIGLSVSTPRHLQTLGLLQRSLDESSYDINY 617

  Fly   430 LFRMAIHTILSIPLYYVHTKVMHDLLNDTVDMDTVNKHYWRLMEQHAGIEAPSDRSEGAIDFPYK 494
            ||.|||..:..:|.........:|:.:...:..|:|.|||.|.|:::||:.|..|||...|...|
  Fly   618 LFTMAIDKVAFLPFALSLDNWRYDVFSGNANKRTMNCHYWNLREKYSGIKPPVLRSEKDFDPGAK 682

  Fly   495 FYVNIDQSFQTQKFISEVLGYQFYREFCKKSYN------RGPLHNCDFYGSLAVGNDLKAMMSLG 553
            :::..:..: .:.|.|.||.:|.||..|::|..      |.|||.||.|...|.||.||.:||.|
  Fly   683 YHIPANIPY-IKYFFSTVLQFQIYRGLCRESGQYVPGDPRKPLHQCDIYRQPAAGNILKTLMSKG 746

  Fly   554 STKPWKQVVGKILPNNTGLSSLALLEYYQPVLDWLNKYNKDANSKIGW 601
            :::||::|:.:.|.... |...||.||:.|:.:||.:.|...|..:||
  Fly   747 ASQPWQEVLEETLREGR-LDGTALREYFAPLEEWLRQENLRTNEYVGW 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-4	NP_610442.2	GluZincin	25..601	CDD:301352	171/609 (28%)
Ance-3	NP_001033904.1	M2_ACE	216..784	CDD:188999	175/619 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16282at33392
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		otm14376
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920