DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-4 and ace2

DIOPT Version :9

Sequence 1:	NP_610442.2	Gene:	Ance-4 / 35909	FlyBaseID:	FBgn0033366	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	XP_002938293.2	Gene:	ace2 / 100486137	XenbaseID:	XB-GENE-487117	Length:	862	Species:	Xenopus tropicalis

Alignment Length:	646	Identity:	161/646 - (24%)
Similarity:	275/646 - (42%)	Gaps:	78/646 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GLLLLLVLIAGIGCATAAANIDLEAKTFVNQSSDRYYRFYNE---------IAAETYSANNEEDF 57
            |||.|..:  |:..||.      .:::..:|:.|...||..|         :|...|:.|..::
Frog     3 GLLWLFCI--GLLLATG------RSQSVTDQARDFLKRFEQEAEVLYHQSALAQWEYNTNITDE- 58

  Fly    58 DALFSKLNNVKRIAEE-------LVSISRQAATYDLDRIRSPQTKMALQELRTAGDLFVLGDDYF 115
                    |.::::|.       ..:.|:.:..::.|.|..|..::.|..|...|.. :|..:.:
Frog    59 --------NAQKMSEAGAKWSAFYTNASKNSEAFNKDYITDPSIELQLIFLSEKGSA-ILPAEKY 114

  Fly   116 SSVQMNLAALQTL-STDKDIEPYLGGANMPNEDDSPLAYFPDIQKIVQSSKDADELKYYWEAWR- 178
            :.:...|..:.|: ||....:|......:|.|        |.:.||:..|.|.:|..:.||.||
Frog   115 TRLNQVLNEMSTIYSTHAVCKPDGSKECLPLE--------PGLDKIMAESIDYEERLWAWEGWRA 171

  Fly   179 --------------DKNQLWASLNFYTIVQSYQRA-AKILEVPVHKLWYRYDSQEMLQQMEQAMT 228
                          |.....|.||.|.....|.|. .:.|...:    |.|...::::.:|:...
Frog   172 GAGKKMRSLYEEYVDLENEAARLNGYNDYGDYWRGNYETLATDM----YAYSRDDLIKDVERTYQ 232

  Fly   229 ELRPAYQQLHAFVRQELHKKYGSDVVNLNGPIPDHLFQQVLEQAWASGSILEDYYPRAQLPEFDE 293
            |:.|.|::||||||..|.:.|||..::.:|.:|.||...:..:.|.:...|...||..:..:...
Frog   233 EILPLYKELHAFVRGNLQQVYGSRYISDSGCLPAHLLGDMWGRFWTNLYPLMVPYPNKESIDVTP 297

  Fly   294 --YVSHLTAKTMVNESENFYTSLGFEPLSAEFHKNQLKEPNQDSPNDDCRPSIFDLTPHVY-LMY 355
              .....|.:.|..|:|.|:.|:....|:..|..|.:.|..:|.....|.|:.:||..:.: :..
Frog   298 TMVAQGWTIERMFKEAEIFFKSVDLFALNENFWNNSMLEEPKDGRQVVCHPTAWDLGMNDFRIKM 362

  Fly   356 CEKVSFRKLMQYHSHMARVYYAQQKSHLPSYYFKAYNLEF--AVGEAVVLSASSPAHLTGRRL-- 416
            |.||:....:..|..:..:.|....:..|.......|..|  ||||.:.|||::|.||...:|
Frog   363 CTKVNMEDFLTVHHELGHIQYDMAYAKQPFMLRDGANEGFHEAVGEIMSLSAATPKHLKHLKLLD 427

  Fly   417 AKEVLSETALMSRLFRMAIHTILSIPLYYVHTKVMHDLLNDTVDMDTVNKHYWRLMEQHAGIEAP 481
            |..|..:...::.|||.|:..:.::|..|:..:....:....:..|...|.:|::..:..|:..|
Frog   428 ANFVEDQETEINFLFRQALAIVGTLPFTYMLEQWRWKVFRGEIPKDQWMKTWWQMKRELVGVVEP 492

  Fly   482 SDRSEGAIDFPYKFYVNIDQSFQTQKFISEVLGYQFYREFCKKSYNRGPLHNCDFYGSLAVGNDL 546
            ....|...|.|..|:|:.|.|| .:.:...:..:||....||.:.:.||||.||...|...|..|
Frog   493 VPHDETYCDPPALFHVSNDYSF-IRYYTRTIYQFQFQDALCKAAGHVGPLHTCDITNSKEAGAKL 556

  Fly   547 KAMMSLGSTKPWKQVVGKILPNNTG---LSSLALLEYYQPVLDWLNKYNKDANSKIGWTAS 604
            :||:.||..|.|.:.:..|    ||   :.|..||:|::|:..||.|.|::...:..|..:
Frog   557 RAMLELGKAKSWTEALQSI----TGGVKMDSQPLLKYFEPLFVWLQKNNEENRRQSTWNTA 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-4	NP_610442.2	GluZincin	25..601	CDD:301352	153/618 (25%)
ace2	XP_002938293.2	Peptidase_M2	23..610	CDD:396123	153/613 (25%)
ace2	XP_002938293.2	Collectrin	622..772	CDD:407175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010