Protein Alignment CG8170 and Tmprss6

DIOPT Version :10

• Sequence 1: NP_610441.2
• Gene: CG8170 / 35908
• FlyBaseID: FBgn0033365
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_082178.2
• Gene: Tmprss6 / 71753
• MGIID: 1919003
• Length: 811
• Species: Mus musculus
• Alignment Length: 519
• Identity: 147/519 - (28%)
• Similarity: 216/519 - (41%)
• Gaps: 138/519 - (26%)

  Fly   418 GPSEYQGTRKSRYYPYKSSRSPRVVFPTNDNVGTTGPSGPAGSSGPSGNGVYFSDNIAFRDQNFG 482
            |..:.||..::.|||  |..||    .|:.:...|.||...|.:      ::| |..|.|.|.:
Mouse   343 GRLDTQGFLRTPYYP--SYYSP----STHCSWHLTVPSLDYGLA------LWF-DAYALRRQKY- 393

  Fly   483 INELAAVQDVRNDYSLQDLDSASEATSSPQSASTFKEKVDITTDTECQHRGGTCEFFLGCWLSG- 546
             |.|.    .:..:.:|:.......|..|     :.|::.:....     |.|..|.....|:|
Mouse   394 -NRLC----TQGQWMIQNRRLCGFRTLQP-----YAERIPMVASD-----GVTINFTSQISLTGP 443

  Fly   547 ------------------------GLIQGTCDGLL--------RGC------------------- 560
                                    ||....|||:.        |.|
Mouse   444 GVQVYYSLYNQSDPCPGEFLCSVNGLCVPACDGIKDCPNGLDERNCVCRAMFQCQEDSTCISLPR 508

  Fly   561 -CHRTAKSANLGSSD-----------FVGNAVDLTDLPQKN----------YGPVNNEPSCGISL 603
             |.|.....| ||.:           |.....|.:.:.:.|          .|.......||:
Mouse   509 VCDRQPDCLN-GSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQSDCRDGSDEQHCDCGL-- 570

  Fly   604 AKQTAQRRIVGGDDAGFGSFPWQAYIRI-GSSRCGGSLISRRHVVTAGHCV---ARATPRQVHVT 664
              |....|||||..:..|.:||||.::| |...|||:||:.|.|:||.||.   :.|:|:...|.
Mouse   571 --QGLSSRIVGGTVSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPKLWTVF 633

  Fly   665 LGDYVINSAVEPLPA-YTFGVRRIDVHPYFKFTPQADRFDISVLTLERTVHFMPHIAPICLPEKN 728
            ||....||.   .|. .:|.|.|:.:|||.:  ..:..:|:::|.|:..|.:...:.|:|||.::
Mouse   634 LGKMRQNSR---WPGEVSFKVSRLFLHPYHE--EDSHDYDVALLQLDHPVVYSATVRPVCLPARS 693

  Fly   729 EDF-LGKFGWAAGWGALNPGSRLRPKTLQAVDVPVIENRICERWHRQNGINVVIYQ---EMLCAG 789
            ..| .|:..|..||||...|..: ..|||.|||.::...:|...:|        ||   .|||||
Mouse   694 HFFEPGQHCWITGWGAQREGGPV-SNTLQKVDVQLVPQDLCSEAYR--------YQVSPRMLCAG 749

  Fly   790 YRNGGKDSCQGDSGGPLM-HDKNGRWYLIGVVSAGYSCASRGQP---GIYHSVSKTVDWVSYVV 849
            ||.|.||:|||||||||: .:.:|||:|.|:||.|..|   |:|   |:|..|::.::|:..|:
Mouse   750 YRKGKKDACQGDSGGPLVCREPSGRWFLAGLVSWGLGC---GRPNFFGVYTRVTRVINWIQQVL 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	96/246 (39%)
Tmprss6	NP_082178.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48
		SEA	88..182	CDD:460188
		LDLa	459..489	CDD:238060	6/29 (21%)
		LDLa	495..525	CDD:238060	5/30 (17%)
		Ldl_recept_a	529..566	CDD:395011	4/36 (11%)
		Tryp_SPc	577..809	CDD:238113	96/248 (39%)