Protein Alignment CG8170 and TMPRSS2

DIOPT Version :10

• Sequence 1: NP_610441.2
• Gene: CG8170 / 35908
• FlyBaseID: FBgn0033365
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001128571.1
• Gene: TMPRSS2 / 7113
• HGNCID: 11876
• Length: 529
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 136/543 - (25%)
• Similarity: 214/543 - (39%)
• Gaps: 149/543 - (27%)

  Fly   385 PQRGFYFGDTEFRTGPPAPVRQFGPQKNFQEYVGPSEYQGTRKSRYYPYKSSR-SPRVVFPTNDN 448
            |..|.|:.:..::...|.|.         |..|.|:.|: ...::|||....: :|||:...::.
Human    46 PAIGPYYENHGYQPENPYPA---------QPTVVPTVYE-VHPAQYYPSPVPQYAPRVLTQASNP 100

  Fly   449 VGTTGPSGPAG-----------------------------------------------SSGPSGN 466
            |..|.|..|:|                                               |||...|
Human   101 VVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCIN 165

  Fly   467 GVYFSDNIAF----RDQN-----FGINELAAVQDVRNDYSLQDLDSASEATSSPQSASTFKEKVD 522
            ...:.|.::.    .|:|     :|.|.:..|      ||.|      ..:..|.....:.|...
Human   166 PSNWCDGVSHCPGGEDENRCVRLYGPNFILQV------YSSQ------RKSWHPVCQDDWNENYG 218

  Fly   523 ITTDTECQHRGGTCEFFLGCWLSGGLIQGTCDGLLRGCCHRTAKSANLGSSDFV------GNAVD 581
               ...|:..|....|:..        ||..|              :.||:.|:      ||
Human   219 ---RAACRDMGYKNNFYSS--------QGIVD--------------DSGSTSFMKLNTSAGN--- 255

  Fly   582 LTDLPQKNYGPVNNEP------------SCGISLAKQTAQRRIVGGDDAGFGSFPWQAYIRIGSS 634
             .|:.:|.|   :::.            :||::| ..:.|.|||||:.|..|::|||..:.:.:.
Human   256 -VDIYKKLY---HSDACSSKAVVSLRCIACGVNL-NSSRQSRIVGGESALPGAWPWQVSLHVQNV 315

  Fly   635 R-CGGSLISRRHVVTAGHCVARATPRQVHVTLGDYVINSAVEPLPAYTFG--VRRIDVHPYFKFT 696
            . ||||:|:...:|||.|||.:......|.|....::.   :....|..|  |.::..||  .:.
Human   316 HVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILR---QSFMFYGAGYQVEKVISHP--NYD 375

  Fly   697 PQADRFDISVLTLERTVHFMPHIAPICLPEKNEDFL---GKFGWAAGWGALNPGSRLRPKTLQAV 758
            .:....||:::.|::.:.|...:.|:|||  |...:   .:..|.:||||.....: ..:.|.|.
Human   376 SKTKNNDIALMKLQKPLTFNDLVKPVCLP--NPGMMLQPEQLCWISGWGATEEKGK-TSEVLNAA 437

  Fly   759 DVPVIENRIC-ERWHRQNGINVVIYQEMLCAGYRNGGKDSCQGDSGGPLMHDKNGRWYLIGVVSA 822
            .|.:||.:.| .|:...|    :|...|:|||:..|..|||||||||||:..||..|:|||..|.
Human   438 KVLLIETQRCNSRYVYDN----LITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSW 498

  Fly   823 GYSCASRGQPGIYHSVSKTVDWV 845
            |..||...:||:|.:|....||:
Human   499 GSGCAKAYRPGVYGNVMVFTDWI 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	82/241 (34%)
TMPRSS2	NP_001128571.1	LDLa	150..185	CDD:238060	7/34 (21%)
		SRCR_2	190..283	CDD:464747	23/136 (17%)
		Tryp_SPc	293..524	CDD:238113	82/241 (34%)