DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8170 and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_610441.2	Gene:	CG8170 / 35908	FlyBaseID:	FBgn0033365	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	251	Identity:	92/251 - (36%)
Similarity:	133/251 - (52%)	Gaps:	15/251 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   598 SCGISLAKQTAQRRIVGGDDAGFGSFPWQAYIRI-GSSRCGGSLISRRHVVTAGHCVARA-TPRQ 660
            :||   .::....|||||:.:....:||||.::. |...||||:|:...::||.|||... .|:.
Human   206 ACG---HRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKS 267

  Fly   661 VHVTLGDYVINSAVEPLPAYTFGVRRIDVHPYFKFTPQADRFDISVLTLERTVHFMPHIAPICLP 725
            ..:.:|  :::....|.|::.  |.:|..|.  |:.|:....||:::.|...:.|...|.|:|||
Human   268 WTIQVG--LVSLLDNPAPSHL--VEKIVYHS--KYKPKRLGNDIALMKLAGPLTFNEMIQPVCLP 326

  Fly   726 EKNEDFL-GKFGWAAGWGALNPGSRLRPKTLQAVDVPVIENRICERWHRQNGINVVIYQEMLCAG 789
            ...|:|. ||..|.:||||...|:......|....||:|.|:||.......||   |...|||||
Human   327 NSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGI---ISPSMLCAG 388

  Fly   790 YRNGGKDSCQGDSGGPLMHDKNGRWYLIGVVSAGYSCASRGQPGIYHSVSKTVDWV 845
            |..||.|||||||||||:..:...|.|:|..|.|..||...:||:|..|:..:||:
Human   389 YLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	611..845	CDD:214473	89/236 (38%)
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	89/237 (38%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:292133	2/6 (33%)
		Tryp_SPc	216..444	CDD:214473	89/236 (38%)
		Tryp_SPc	217..447	CDD:238113	89/237 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910