DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8170 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_610441.2	Gene:	CG8170 / 35908	FlyBaseID:	FBgn0033365	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	383	Identity:	101/383 - (26%)
Similarity:	178/383 - (46%)	Gaps:	63/383 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 QNFGINELAAVQDVRNDYSLQDLDSASEATSSPQSASTFKEKVDITTDTECQHRGGTCEFFLGCW 543
            ::|......||:..::..:||.||||:....|    :.|....:...:|.|:..|.:.:
Human    94 KSFPEGPAVAVRLSKDRSTLQVLDSATGNWFS----ACFDNFTEALAETACRQMGYSSK------ 148

  Fly   544 LSGGLIQGTCDGLLRGCCHRTAKSANLGSSDFVGNAVDLTDLPQK-----NYGPVNNEP------ 597
                               .|.::..:|....: :.|::|:..|:     :.||..:..
Human   149 -------------------PTFRAVEIGPDQDL-DVVEITENSQELRMRNSSGPCLSGSLVSLHC 193

  Fly   598 -SCGISLAKQTAQRRIVGGDDAGFGSFPWQAYIRIGSSR-CGGSLISRRHVVTAGHCVARATPRQ 660
             :||.||...    |:||.::|...|:|||..|:..... ||||::....|:||.||..:
Human   194 LACGKSLKTP----RVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRK----- 249

  Fly   661 VHVTLGDYVINSAVEPLPAY-TFGVRRIDVHPYFKFTPQADRFDISVLTLERTVHFMPHIAPICL 724
             |..:.::.:.:..:.|.:: :..|.:|.:..:....|:.:  ||:::.|:..:.|...:.||||
Human   250 -HTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN--DIALMKLQFPLTFSGTVRPICL 311

  Fly   725 PEKNEDFLGKFG-WAAGWG-ALNPGSRLRPKTLQAVDVPVIENRICERWHRQNGINVVIYQEMLC 787
            |..:|:...... |..||| ....|.::....||| .|.||::..|.......|   .:.::|:|
Human   312 PFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQA-SVQVIDSTRCNADDAYQG---EVTEKMMC 372

  Fly   788 AGYRNGGKDSCQGDSGGPLMHDKNGRWYLIGVVSAGYSCASRGQPGIYHSVSKTVDWV 845
            ||...||.|:||||||||||: ::.:|:::|:||.||.|.....||:|..||..::|:
Human   373 AGIPEGGVDTCQGDSGGPLMY-QSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	611..845	CDD:214473	75/237 (32%)
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	75/238 (32%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	18/118 (15%)
		Tryp_SPc	204..429	CDD:214473	75/237 (32%)
		Tryp_SPc	205..432	CDD:238113	75/238 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910