Protein Alignment CG8170 and Tmprss2

DIOPT Version :10

• Sequence 1: NP_610441.2
• Gene: CG8170 / 35908
• FlyBaseID: FBgn0033365
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_056590.2
• Gene: Tmprss2 / 50528
• MGIID: 1354381
• Length: 490
• Species: Mus musculus
• Alignment Length: 609
• Identity: 148/609 - (24%)
• Similarity: 218/609 - (35%)
• Gaps: 210/609 - (34%)

  Fly   306 YEPQPY-SEDASPVPPPTQYEQHETRHTRQLYFDSDTASSSFEFPGLVSNSKPHGLKLYRDDVTK 369
            ||...| ||...|..||.                                 .|:|..||
Mouse    15 YENHGYQSEHICPPRPPV---------------------------------APNGYNLY------ 40

  Fly   370 FGDINGPITALPQQRPQRGFYFGDTEFRTGPPAPVRQFGPQKNFQEYVGPSEYQGTRKSRYYPYK 434
                       |.|      |:         |:||.|:.|:...|...................|
Mouse    41 -----------PAQ------YY---------PSPVPQYAPRITTQASTSVIHTHPKSSGALCTSK 79

  Fly   435 SSRSPRVVFPTNDNVGT--TGPSGPA------------------GSSGPSGNGVYFSDNIAF--- 476
            |.:|..:...    :||  ||.:..|                  ||||...:...:.|.:|.
Mouse    80 SKKSLCLALA----LGTVLTGAAVAAVLLWRFWDSNCSTSEMECGSSGTCISSSLWCDGVAHCPN 140

  Fly   477 -RDQN-----FGINEL-------------------------AAVQDV---RNDYSLQDLDSASEA 507
             .|:|     :|.:.:                         ||.:|:   .|.||.|.:...|.|
Mouse   141 GEDENRCVRLYGQSFILQVYSSQRKAWYPVCQDDWSESYGRAACKDMGYKNNFYSSQGIPDQSGA 205

  Fly   508 TSSPQSASTFKEKVDITTDTECQHRGGTCEFFLGCWLSGGLIQGTCDGLLRGCCHRTAKSANLGS 572
            ||                             |:...:|.|.:.     |.:...|..:.|:.:
Mouse   206 TS-----------------------------FMKLNVSSGNVD-----LYKKLYHSDSCSSRM-- 234

  Fly   573 SDFVGNAVDLTDLPQKNYGPVNNEPSCGISLAKQTAQRRIVGGDDAGFGSFPWQAYIRI-GSSRC 636
                  .|.|..:            .||:...|:  |.|||||.:|..|.:|||..:.: |...|
Mouse   235 ------VVSLRCI------------ECGVRSVKR--QSRIVGGLNASPGDWPWQVSLHVQGVHVC 279

  Fly   637 GGSLISRRHVVTAGHCVAR--ATPRQVHVTLGDYVINSAVEPLPAYTFG----VRRIDVHPYFKF 695
            |||:|:...:|||.|||..  ::||......|  ::..::     ..:|    |.::..||  .:
Mouse   280 GGSIITPEWIVTAAHCVEEPLSSPRYWTAFAG--ILRQSL-----MFYGSRHQVEKVISHP--NY 335

  Fly   696 TPQADRFDISVLTLERTVHFMPHIAPICLPEKNEDF-LGKFGWAAGWGALNPGSRLRPKT---LQ 756
            ..:....||:::.|:..:.|...:.|:|||...... |.:..|.:||||    :..:.||   |.
Mouse   336 DSKTKNNDIALMKLQTPLAFNDLVKPVCLPNPGMMLDLDQECWISGWGA----TYEKGKTSDVLN 396

  Fly   757 AVDVPVIENRICERWHRQNGINVVIYQEMLCAGYRNGGKDSCQGDSGGPLMHDKNGRWYLIGVVS 821
            |..||:||...|...:..|.:   |...|:|||:..|..|||||||||||:..|||.|:|||..|
Mouse   397 AAMVPLIEPSKCNSKYIYNNL---ITPAMICAGFLQGSVDSCQGDSGGPLVTLKNGIWWLIGDTS 458

  Fly   822 AGYSCASRGQPGIYHSVSKTVDWV 845
            .|..||...:||:|.:|:...||:
Mouse   459 WGSGCAKALRPGVYGNVTVFTDWI 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	86/245 (35%)
Tmprss2	NP_056590.2	LDLa	112..147	CDD:238060	8/34 (24%)
		SRCR_2	152..247	CDD:464747	22/148 (15%)
		Tryp_SPc	254..485	CDD:238113	86/245 (35%)