DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8170 and tmprss2

DIOPT Version :9

Sequence 1:	NP_610441.2	Gene:	CG8170 / 35908	FlyBaseID:	FBgn0033365	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001008623.1	Gene:	tmprss2 / 494080	ZFINID:	ZDB-GENE-041212-48	Length:	486	Species:	Danio rerio

Alignment Length:	299	Identity:	96/299 - (32%)
Similarity:	138/299 - (46%)	Gaps:	18/299 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   551 GTCDGLLRGCCHRTA-KSANLGSSDFVGNAVDLTDLPQKNYGPVNNEPSCGISLAKQTAQRRIVG 614
            |..|.|.:..|.... |....|....:..::|.....|.:.........||     ::...||||
Zfish   195 GFNDNLAKQACAEIGYKDTYSGYQGILSPSLDFISACQSSTAVSLKCTDCG-----RSTGNRIVG 254

  Fly   615 GDD-AGFGSFPWQAYIRI-GSSRCGGSLISRRHVVTAGHCVARATPRQVHVTLGDYVINSAVEPL 677
            |.. ...|.:|||..:.. |...||||:|:...::||.|||.:.:..........|:..|  |..
Zfish   255 GTTVTSKGVWPWQVSLHYSGRHLCGGSIITPYWILTAAHCVHQFSNPGGWTVYAGYLTQS--EMA 317

  Fly   678 PAYTFGVRRIDVHPYFKFTPQADRFDISVLTLERTVHFMPHIAPICLPEKNEDFLGKFG-WAAGW 741
            .|....|.||.:|   .|.|..:..||:::.|...:....:|.|:|||.|...|..:.. :..||
Zfish   318 SASGNSVNRIVIH---DFNPNTNENDIALMRLNTALTISTNIRPVCLPNKGMSFTAQQDCYVTGW 379

  Fly   742 GALNPGSRLRPKTLQAVDVPVIENRICERWHRQNGINVVIYQEMLCAGYRNGGKDSCQGDSGGPL 806
            |||..|.. ...|||...:.:|::.||......||:   |...|:|||...||.|||||||||||
Zfish   380 GALFSGGS-SSATLQEAKIQLIDSTICNSRPVYNGL---ITDTMICAGKLAGGVDSCQGDSGGPL 440

  Fly   807 MHDKNGRWYLIGVVSAGYSCASRGQPGIYHSVSKTVDWV 845
            :.:....|:|:|..|.|..||.|.:||:|.:|:..:||:
Zfish   441 VTNVRSLWWLLGDTSWGDGCAVRNKPGVYGNVTYFLDWI 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	611..845	CDD:214473	85/236 (36%)
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	85/237 (36%)
tmprss2	NP_001008623.1	LDLa	132..168	CDD:238060
		SRCR_2	173..248	CDD:295335	10/57 (18%)
		Tryp_SPc	251..479	CDD:214473	85/236 (36%)
		Tryp_SPc	252..482	CDD:238113	85/237 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000