DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8170 and Corin

DIOPT Version :9

Sequence 1:	NP_610441.2	Gene:	CG8170 / 35908	FlyBaseID:	FBgn0033365	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	1097	Identity:	244/1097 - (22%)
Similarity:	366/1097 - (33%)	Gaps:	418/1097 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ATDENNTNTTTASRSTRNTWRWSRLALAVSLFAYCCCASSAATPTTSVTTAALLSG--HQLLPWQ 66
            :::.:|:...|.|:|       |:...:||..|....|:||.:.|.|..|.:.:||  ..::| .
  Fly   410 SSNSSNSIGETQSQS-------SKEPSSVSASASTSSAASAGSSTISSGTMSSMSGPCPAVVP-P 466

  Fly    67 TAAAT----AATTPSTARNLYAPHQSFSR-H----------------DDISFKDLRQRSDGTVVQ 110
            |.|.|    ....|....|::.|.::.|| |                ..|::..::||.|.|:
  Fly   467 TDAITKRPGPPEPPLRQANVFDPVETGSRGHPPPPLTVRNKLGRNKPPPITYPRMQQRQDSTL-- 529

  Fly   111 SFGSYRTARQFGGYSTTAQRRSDPAVEIIPAPSVELPQGELITVPKQLVPTMPENVTRQGRRRNY 175
            |..||..:.. .||::          :::.||.:...||                    ||:.|
  Fly   530 SSDSYSISSS-PGYNS----------KLMEAPLLGSQQG--------------------GRKSN- 562

  Fly   176 MYIPLQTEGENGSA----ALLQLRPSRNATLSALGPPADGVAAVAHEFGADLATQGS---GPEQP 233
                     ..|||    .|:.|.|:|     .||....|.              ||   ||..|
  Fly   563 ---------APGSAQRQTPLMDLAPTR-----FLGGAGGGT--------------GSGKQGPAMP 599

  Fly   234 P--LALELGPERTERSDLMAAASS---TDKLEYAE--PENTSRRV-----------GFQF-PSYS 279
            |  ..:....:.|..||..:..||   ..||..|.  |..:::|:           |.|. |...
  Fly   600 PPRSKINFRQDSTISSDSFSQTSSPGYNPKLMEAPLLPSLSAKRLCSAPAPIVCRQGVQHEPIEE 664

  Fly   280 LKP---ASPFHPQAYREDNPIFGDTSAGGYEPQPYS-------EDASPVPPPTQYEQHETRHTRQ 334
            |:|   .||.|              .|.|   ||.|       ::.:   |.|...||:..:.|:
  Fly   665 LEPPQTISPLH--------------KAAG---QPSSLQTIVRFQNGA---PHTMSLQHQIINRRK 709

  Fly   335 ---------------------------------LYFDSDTASSSFEFPGLVSNSKPHGLKLYRDD 366
                                             .||::        :|.:...:|.....::.:|
  Fly   710 SSNPYITNGRLKFRLFQILINAFALLAIAGGLAAYFNA--------YPTIKFVNKTIINTIHVED 766

  Fly   367 VTKFGDINGPITALPQQRPQRGFYFGDTEFRTGPPAPVRQFGPQKNFQEYVGP----------SE 421
            .|.||....|.|.||.          ...|..||..|..    ...|..|:|.          ..
  Fly   767 TTSFGKNPAPGTCLPI----------IVRFCQGPQIPYN----YTVFPNYIGHFGQLETQTDLDS 817

  Fly   422 YQGTRKSRYYPYKSSRSPRVVFPTNDNVGTTGPSGPA------------------GSSGPSG-NG 467
            |:.....|.|...|.....:..|.....|.|.|  |.                  |.|.|.. |.
  Fly   818 YEALVDVRCYELVSLFLCTLFVPKCGQSGATVP--PCKTLCTETMRRCGFFFDVFGLSLPEYLNC 880

  Fly   468 VYFSDNIAFRDQNFGINELAAV---------------------QDVRNDYSLQDLDSASEATSSP 511
            ..|.|..:..| ..|::|:..|                     |:...|..|..:|.|.||
  Fly   881 KLFKDFPSSED-CVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEA---- 940

  Fly   512 QSASTFKEKVDITTDTECQHRGGTCEFFLG---CWLSGGLIQGT---CDGLL--------RGCCH 562
                            :|: |.|..|.:.|   |       .||   |||::        |.|..
  Fly   941 ----------------KCE-RCGPDEIYCGDSQC-------IGTKHICDGIIDCPYGQDERNCLR 981

  Fly   563 RTAKSANLGSS------------------------------DFVG-NAVDLT------------- 583
            .:.::.::|:.                              ..:| :||:.|
  Fly   982 LSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLA 1046

  Fly   584 -----------------------------------DLPQKNYGPVNNEPSCG-ISLAKQTAQRRI 612
                                               ||...||       .|| :...:....|||
  Fly  1047 TVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLTCSNY-------ECGRVKRGRHKPSRRI 1104

  Fly   613 VGGDDAGFGSFPWQAYIRIGSSR---CGGSLISRRHVVTAGHCVARATPRQVHVTLGDYVINSAV 674
            :||..|..|::|:.|.|..|..:   |.|.|||.:.|:||.|||...:.    :.|.|:.|...|
  Fly  1105 IGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSV----IDLEDWTIQLGV 1165

  Fly   675 EPLPAYTFGVRRIDV-----HPYFKFTPQADRFDISVLTLERTVHFMPHIAPICLPEKNEDFL-- 732
            ....::|:..:::.|     ||.:......|. ||::..|...|.|..|:.|:|||..:...|
  Fly  1166 TRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDN-DIALFQLATRVAFHEHLLPVCLPPPSVRNLHP 1229

  Fly   733 GKFGWAAGWGALNPGSRLRPKT-----LQAVDVPVIENRICERWHRQNGINVVIYQEMLCAGYRN 792
            |......|||......   ||:     :..|.||:|....|:.|..    |:.:.:.|:|||:.:
  Fly  1230 GTLCTVIGWGKREDKD---PKSTYEYIVNEVQVPIITRNQCDEWLD----NLTVSEGMVCAGFDD 1287

  Fly   793 GGKDSCQGDSGGPLM----HDKNGRWYLIGVVSAGYSCASRGQPGIYHSVSKTVDWV 845
            ||||:|||||||||:    .:|| ||::.|:||.|..||....||:|.:|.:.|.|:
  Fly  1288 GGKDACQGDSGGPLLCPYPGEKN-RWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWI 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8170	NP_610441.2	Tryp_SPc	611..845	CDD:214473	86/252 (34%)
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	86/253 (34%)
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	26/132 (20%)
		LDLa	911..942	CDD:238060	7/50 (14%)
		LDLa	945..979	CDD:238060	10/40 (25%)
		SR	980..>1034	CDD:214555	4/53 (8%)
		SRCR	992..1086	CDD:278931	6/93 (6%)
		Tryp_SPc	1103..1343	CDD:214473	86/252 (34%)
		Tryp_SPc	1104..1346	CDD:238113	86/253 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010